个人简介

David Mahns is a Senior Lecturer in Integrative Physiology at the School of Medicine, University of Western Sydney. After completing his doctoral work in Cardiovascular Physiology (1999) David undertook post-doctoral work in sensory physiology under the direction of Professor Mark Rowe as a NHMRC research officer. In 2003 he was appointed as Lecturer & Course coordinator (2003-2006). In 2007 David was appointed as a senior lecturer in Integrative Physiology at the University of Western Sydney. David specializes in quantifying the contribution of sensory nerves arising from skin and deep structures such as muscle and bone to perception. Recent work has focused on defining how we distinguish between non-painful (eg innocuous touch) and painful stimuli. These questions are addressed using psychophysical observations and detailed electrophysiological recording. In collaboration with Professor Macefield we are examining the contribution of different sensory nerves to the abnormal condition of allodynia where gentle touch is perceived painful.

研究领域

Integrative Physiology

Integrative physiology Microneurography Neuroscience Pain and Tactile sensibility Sensory physiology

近期论文

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Shaikh, S., Shortland, P., Lauto, A., Barton, M., Morley, J. and Mahns, D. (2016), 'Sensory perturbations using suture and sutureless repair of transected median nerve in rats', Somatosensory and Motor Research, vol 33, no 1 , pp 20 - 28. Mawad, D., Warren, C., Barton, M., Mahns, D., Morley, J., Pham, B., Pham, N., Kueh, S. and Lauto, A. (2015), 'Lysozyme depolymerization of photo-activated chitosan adhesive films', Carbohydrate Polymers, vol 121 , pp 56 - 63. Nagi, S., Dunn, J., Birznieks, I., Vickery, R. and Mahns, D. (2015), 'The effects of preferential A- and C-fibre blocks and T-type calcium channel antagonist on detection of low-force monofilaments in healthy human participants', BMC Neuroscience, vol 16, no 1 . Shaikh, S., Nagi, S., McGlone, F. and Mahns, D. (2015), 'Psychophysical investigations into the role of low-threshold C fibres in non-painful affective processing and pain modulation', PLoS One, vol 10, no 9 . Samour, M., Nagi, S. and Mahns, D. (2015), 'Cav3.2-expressing low-threshold C fibres in human hairy skin contribute to cold allodynia : a non-TRPV1- and non-TRPM8-dependent phenomenon', Pain, vol 156, no 8 , pp 1566 - 1575. Condon, M., Birznieks, I., Hudson, K., Chelvanayagam, D., Mahns, D., Olausson, H. and Macefield, V. (2014), 'Differential sensitivity to surface compliance by tactile afferents in the human finger pad', Journal of Neurophysiology, vol 111, no 6 , pp 1308 - 1317. Barton, M., Morley, J., Stoodley, M., Lauto, A. and Mahns, D. (2014), 'Nerve repair : toward a sutureless approach', Neurosurgical Review, vol 37, no 4 , pp 585 - 595. Barton, M., Morley, J., Mahns, D., Mawad, D., Wuhrer, R., Fania, D., Frost, S., Loebbe, C. and Lauto, A. (2014), 'Tissue repair strength using chitosan adhesives with different physical-chemical characteristics', Journal of Biophotonics, vol 7, no 11-12 , pp 948 - 955. Arabzadeh, E., Clifford, C., Harris, J., Mahns, D., Macefield, V. and Birznieks, I. (2014), 'Single tactile afferents outperform human subjects in a vibrotactile intensity discrimination task', Journal of Neurophysiology, vol 112, no 10 , pp 2382 - 2387. Nagi, S. and Mahns, D. (2013), 'C-tactile fibers contribute to cutaneous allodynia after eccentric exercise', Journal of Pain, vol 14, no 5 , pp 538 - 548. Mahns, D. and Nagi, S. (2013), 'An investigation into the peripheral substrates involved in the tactile modulation of cutaneous pain with emphasis on the C-tactile fibres', Experimental Brain Research, vol 227, no 4 , pp 457 - 465. Nagi, S. and Mahns, D. (2013), 'Mechanical allodynia in human glabrous skin mediated by low-threshold cutaneous mechanoreceptors with unmyelinated fibres', Experimental Brain Research, vol 231, no 2 , pp 139 - 151. Barton, M., Morley, J., Stoodley, M., Ng, K., Piller, S., Duong, H., Mawad, D., Mahns, D. and Lauto, A. (2013), 'Laser-activated adhesive films for sutureless median nerve anastomosis', Journal of Biophotonics, vol 6, no 11-12 , pp 938 - 949. Barton, M., Morley, J., Stoodley, M., Shaikh, S., Mahns, D. and Lauto, A. (2013), 'Long term recovery of median nerve repair using laser-activated chitosan adhesive films', Journal of Biophotonics, . Rubin, T., Lake, S., Van der Kooi, S., Lucas, N., Mahns, D., Henderson, L. and Macefield, V. (2012), 'Predicting the spatiotemporal expression of local and referred acute muscle pain in individual subjects', Experimental Brain Research, vol 223, no 1 , pp 11 - 18. Barton, M., Piller, S., Mahns, D., Morley, J., Mawad, D., Longo, L. and Lauto, A. (2012), 'In vitro cell compatibility study of rose bengal-chitosan adhesives', Lasers in Surgery and Medicine, vol 44, no 9 , pp 762 - 768. Lauto, A., Stoodley, M., Barton, M., Morley, J., Mahns, D., Longo, L. and Mawad, D. (2012), 'Fabrication and application of rose bengal-chitosan films in laser tissue repair', Journal of Visualized Experiments, , no 68 . Nagi, S., Rubin, T., Chelvanayagam, D., Macefield, V. and Mahns, D. (2011), 'Allodynia mediated by C-tactile afferents in human hairy skin', Journal of Physiology, vol 589, no 16 , pp 4065 - 4075. Ivanusic, J., Sahai, V. and Mahns, D. (2009), 'The cortical representation of sensory inputs arising from bone', Brain Research, vol 1269, no 0 , pp 47 - 53. Weerakkody, N., Mahns, D., Taylor, J. and Gandevia, S. (2007), 'Impairment of human proprioception by high-frequency cutaneous vibration', The Journal of Physiology, vol 581, no 3 , pp 971 - 980.