个人简介
李韶
职务: Professor
专业: 生理学
Education/Working Experience
Education Experience:
2004/09-2007/06 Postgraduate student for Doctor Degree in Department of Physiology, Dalian Medical University. For Doctor’s Degree (Neurophysiology)
1989/09-1992/07 Postgraduate student for Master Degree in Department of Physiology, Tongji Medical University. Master’s Degree (Physiology)
1982/09-1987/07 Undergraduate student in Binzhou Medical College. Bachelor of Science (Medicine)
Working Experience
2009/07-Now, Professor and Supervisor of PhD Candidates in Department of Physiology, Dalian Medical University, Dalian, PR, China
2009/01-2009/06 Research Fellow in Department of Pharmacology, Yong Loo Lin School of Medicine, Centre for Life Sciences (CeLS), National University of Singapore, Singapore.
2005/10-2008/08 Research Scientist in Department of Clinical Research, Singapore General Hospital, Singapore
2000/09-2005/09 Professor & associate professor in Department of Physiology, Dalian Medical University, P.R. China
2000/01-2000/09 Research Fellow in Unit of pain, Shanghai Institute of Physiology, Chinese Academy of Sciences. Shanghai, P.R. China
1996/09-1999/12 Associate professor in Department of Physiology, Binzhou Medical University，Binzhou, P.R. China
1996/01-1996/09 Research Fellow in Department of Physiology, Tongji Medical University. Wuhan, P.R. China
1992/07-1996/01 Lecturer in Department of Physiology, Binzhou Medical College. Binzhou, Shandong Province Department of Physiology, Binzhou Medical University, Binzhou, P.R. China
Awards in the past five years:
1. Liaoning provincial third-grade progress prize of science and technology in 2015 (No: 2015J-3-095-1) (The basis and clinical study on the correlation between the sodium channel subtype Nav1.6 and the pathogenesis of Alzheimer's disease)
2. Liaoning medical association third-grade progress prize of science and technology in 2015(No: 2015-3-09-01.) in 2015. (Relationship between Nav1.6 and the pathogenesis of Alzheimer's disease and the study of intervention targets)
3. Liaoning provincial second-grade progress prize of science and technology in 2013 (No: 2013J-2-58-02) (The basic and clinical research on the treatment of refractory epilepsy with Chinese herbal scorpion venom)
4. Liaoning provincial third-grade progress prize of science and technology in 2012. (2012J-2-61-03) (The basic and clinical research on the protection and repair of nerve injury)
5. The third prize of Chinese medical science and technology in 2011. (No: 201103149P0803) (A comparative study of the new targets, mechanisms and strategies for the prevention and treatment of neurological diseases)
Research Projects/Grants
1. National Nature Science Foundation (No. 81571061), The study on the effect and underlying mechanisms of Nav1.6 in the neural networks dysfunction in Alzheimer's disease. 2016.01-2019.12, 681 thousand Yuan, Principal Investigator (No.1)
2. National Nature Science Foundation (No. 81371223), The study on the molecular mechanism Aβ formation and regulation at node of Ranvier in Alzheimer's disease. 2014.01-2017.12， 650 thousand Yuan, Principal Investigator (No.1)
3. National Nature Science Foundation （No. 30871006）The interaction of amyloid precursor protein and Nav1.6 at node of Ranvier in correlation with Alzheimer's diseases. 2009.01-2011.12 , 650 thousand Yuan, Principal Investigator (No.1)
4. the specialized research fund for the doctoral program of higher education of china (20122105110010), Study on amyloid precursor protein metabolism and its regulation target at nodes of Ranvier, 2013.01-2015.12, 120 thousand, Principal Investigator (No.1)
5. Liaoning Provincial Department of Education (L2014343), Neural protection of natural products on the scorpion source of Alzheimer's disease research, 2014.01.01-2017.12.30, 30 thousand, Principal Investigator (No.1)
Admission Plan/Requirements
1-2 PhD candidates & 2-3 M.D candidates/ year
近期论文
查看导师新发文章
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Selected Publication in the past five years （*corresponding author）
1. Wang X, Zhang XG, Zhou TT, Li, Jang CL, Xiao ZC, Ma QH, Li S*. Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ1−42. Frontiers in Neuroscience, 2016, published: 09March2016 doi: 10.3389/fnins.2016.00094 IF4.02
2. Lan YL, Zou S, Zhang C, Li J, Xu Y, Li S* Update on the effect of estradiol in postmenopause women with Alzheimer's disease: A systematic review. Acta Neurol Belg, 2016, DOI 10.1007/s13760-015-0593-y. IF 0.9
3. Yang JY*,Wei W, Liu JQ, Lan YL, Wang HB, Li S*. Role of bladder hydrodistention and intravesical sodium hyaluronate in the treatment of interstitial cystitis. Urology Journal. 2015,12(06): 2417-2421. IF 0.565.
4. Lan YL#, Zou S#, Chen JJ, Zhao J*, Li S*. The neuroprotective effect of the association of aquaporin-4/glutamate transporter 1 (AQP4/GLT-1) against Alzheimer’s disease. Neural Plasticity. 2016 (2016), Article ID 4626593, 8 pages http://dx.doi.org/10.1155/2016/4626593. IF3.582
5. Zhou TT#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*. Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease. Int Immunopharmacol. 2015 Nov 5. pii: S1567-5769(15) 30165 -X. doi: 10.1016/j.intimp.2015.10.032. [Epub ahead of print] IF 2.474
6. Zhou T#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*.Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease. Neuropharmacology. 2015 Oct 23; 101: 480-489. doi: 10.1016/j.neuropharm. 2015.10.024. [Epub ahead of print] IF 5.106
7. Lan YL#, Zhao J#, Ma TH*, Li S*. The potential roles of aquaporin 4 in Alzheimer's disease. Mol Neurobiol. 2015 Oct 3. [Epub ahead of print] IF 5.147
8. Lan YL#, Zhao J#, Ma TH*, Li S*. The great significance of research into the physiological relevance between AQP4 and vasopressin for studying Alzheimer's disease. J Alzheimers Dis Parkinsonism 5:192.doi:10.4172/2161- 0460.1000192 IF 1.18
9. Cao Z, Wu XF, Peng Y, Zhang R, Li N, Yang JY, Zhang SQ, Zhang WQ, Zhao J*, Li S*. Scorpion Venom Heat-Resistant Peptide Attenuates Glial Fibrillary Acidic Protein Expression via c-Jun/AP-1. Cell Mol Neurobiol. 2015 Nov;35(8):1073-9. doi: 10.1007/s10571-015-0215-5. Epub 2015 Jul 2. IF 2.51
10. Lan YL, Zhao J, Ma TH*, Li S*. The research update on the potential roles of aquaporin 4 in neuroinflammation. Acta Neurol Belg, 2015Aug 11. [Epub ahead of print] IF 0.9
11. Yang JY*, Yang G, Ren J, Zhao J*, Li S*. Caffeine suppresses GABA receptor-mediated current of rat primary sensory neurons via inhibiting intracellular phosphodiesterase. Neurophysiology April 2015, Volume 47, Issue 2, pp 108-114 IF 0.2
12. Lan YL, Zhao J, Li S*. Update on the Neuroprotective Effect of Estrogen Receptor Alpha against Alzheimer ’s disease. J Alzheimer’s Dis. 2015;43(4):1137-48. IF 4.151
13. Zhang MY, Zheng CY, Zou MM, Zhu JW, Zhang Yan, Sun M, Wang J, Liu CF, Xiao ZC, Li S *, Ma QH and Xu RX.Lamotrigine Attenuates Deficits in Synaptic Plasticity and Accumulation of Amyloid Plaques in APP/PS1 Transgenic Mice. Neurobiol Aging. 2014 Dec;35(12):2713-25. doi: 10.1016/ j. neurobiolaging. 2014.06.009. Epub 2014 Jun 16. IF 5.013
14. Wang T, Wang SW, Zhang Y, Wu XF, Peng Y, Cao Z, Ge BY, Wang X, Wu Q, Lin JT, Zhang WQ, Li S*, Zhao J. Scorpion Venom Heat-Resistant Peptide (SVHRP) Enhances Neurogenesis and Neurite Outgrowth of Immature Neurons in Adult Mice by Up-Regulating Brain-Derived Neurotrophic Factor (BDNF). PLoS One. 2014 Oct 9; 9(10): e109977. IF 3.234
15. intao Lin, Shuangyue Li, Mingzhong Sun, Cuili Zhang, Wenbo Yang, Zehui Zhang, Xiaojie Li and Shao Li*，Microbial lipid production by oleaginous yeast in D-xylose solution using a two-stage culture mode.RSC Advance 2014,(4), 34944-34949. IF 3.84
16. Lan YL, Zhao J, Li S*. Estrogen receptors’ neuroprotective effect against glutamate-induced neurotoxicity. Neurol Sci.2014 Nov; 35(11):1657-62.. IF 1.5
17. Song Y, Li S, Song B, Zhang Y, Gao W, Li N, Fan K, Ma J*. The pathological changes in the spinal cord after dural tear with and without autologous fascia repair. Eur Spine J (2014) 23:1531-1540.IF 2.473
18. Xu DE, Zhang WM, Yang ZZ, Zhu HM, Yan K, Li S, Bagnard D, Dawe GS, Ma QH, Xiao ZC*Amyloid precursor protein at node of Ranvier modulates nodal formation.Cell AdhMigr. 2013 Dec; 29(6):752-60.IF 4.505
19. Wang ZC, Zhao J, Li S*，Dysregulation of Synaptic and ExtrasynapticN-methyl-D-aspartate receptors induced by amyloid-β. Neurosci Bull. 2013 Dec;29(6):752-60. doi: 10.1007/s12264-013-1383-2. Epub 2013 Oct 17. IF 1.85
20. Li X, Liu J, Liang S, Guan K, An L, Wu X, Li S,Sun C*. Temporal Modulation of Sodium Current Kinetics in Neuron Cells by Near-Infrared Laser. Cell Biochem Biophys.2013 Dec;67(3):1409-19. IF 2.384
21. Xu JP, Zhao J,LiS*. Roles of NG2 glial cells in diseases of the central nervous system. Neurosci Bull. 2011 Dec;27(6):413-21. IF1.8
22. Li S*, Luo J, Xi W, Guan BC and Sun CK*. Effects of Ginkgo biloba Extracts on NMDAactivated Currents in Acutely Isolated Hippocampal Neurons of the rat. Phytother Res. 2011 Jan; 25(1): 137-41. IF 2.01
学术兼职
The member of the American Society of Neuroscience
The member of the Chinease Society for Neuroscience;
The council member of Chinese Gerontological Society of aging and anti-aging;
The council member of Chinese Association of Physiological Sciences.
The Editorial Board Member of Journal of Alzheimer’s disease.
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