个人简介
王青山
职务: 教授
专业: 毒理学
Education/Working Experience
2015-present Professor, Dalian Medical University
Research Focus: Role of glia-mediated neuroinflammation in neurodegeneration
2014-2015 Research Fellow, National Institute of Environmental Health Sciences
Research Focus: Role of glia-mediated neuroinflammation in
pre-motor/non-motor symptoms of Parkinson’s disease
2009-2014 Visiting Fellow, National Institute of Environmental Health Sciences
Research Focus: Role of microglia in inflammation-mediated
neurodegeneration in Parkinson’s disease: models,
mechanisms, and therapeutic interventions
2006-2009 Doctor of Medicine, School of Public Health, Shandong University
2003-2006 Master of Medicine, School of Public Health, Shandong University 1998-2003 Bachelor of Medicine, School of Public Health, Shandong University
Research Projects/Grants
2015-2020 Principle Investigator: Grant of “QIZHEN Project”
2012-2015 Secondary Principle Investigator: National Natural Science Foundation
of China (No. 81172708)
2010-2012 Principle Investigator: National Natural Science Foundation of China
(No. 30901212).
Admission Plan/Requirements
One student each year.
The successful candidate will have:
1. A relevant bachelor or master degree;
2. An outstanding record of undergraduate or Master’s degree work;
3. Some background in or willingness to familiarize himself/herself with issues related to role of glia-mediated neuroinflammation in environmental toxins-induced neurodegeneration;
4. Strong oral and written communication skills in English and the ability to publish the results of research in scientific peer-reviewed journals;
5. Capacity to collaborate across the academic disciplines;
6. Ability to work both independently and as part of the team with good organizational and social skills.
近期论文
查看导师新发文章
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1. Wang Q*, Qian L, Chen SH, Chu CH, Wilson B, Esteban O, Ali S, Robinson B, Rao D, Hong JS*. Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models. Brain. 2015, 1247-1262.
2. Wang Q*, Oyarzabal E, Wilson B, Qian L, Hong JS*. Substance P enhances microglial density in the substantia nigra through neurokinin-1 receptor/NADPH oxidase-mediated chemotaxis in mice. Clinical Science. 2015, 757-767.
3. Jiang L, Chen S, Chu C, Wang S, Esteban O, Wilson B, Sanders V, Xie K*, Wang Q*, Hong J*. A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis. Glia. 2015, 1057-1072.
4. Chen SH, Oyarzabal EA, Sung YF, Chu CH, Wang Q, Chen SL, Lu RB, Hong JS. Microglial regulation of immunological and neuroprotective functions of astroglia. Glia. 2015, 118-31
5. Wang Q*, Chu CH, Qian L, Chen SH, Wilson B, Oyarzabal E, Jiang L, Ali S, Robinson B, Kim HC, Hong JS*. Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. Journal of Neuroscience. 2014, 12490-503.
6. Wang Q, Chu CH, Oyarzabal E, Jiang L, Chen SH, Wilson B, Qian L, Hong JS. Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases. Glia. 2014, 2034-43.
7. Chu CH, Chen SH, Wang Q, Langenbach R, Li H, Zeldin D, Chen SL, Wang S, Gao H, Lu RB, Hong JS. PGE2 Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition. Molecular Neurobiology. 2015, 587-600
8. Wang Q#, Shin EJ#, Nguyen XK, Li Q, Bach JH, Bing G, Kim WK, Kim HC, Hong JS. Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice. Journal of Neuroinflammation. 2012, 9:124.
9. Wang Q, Zhou H, Gao H, Chen SH, Chu CH, Wilson B, Hong JS. Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase. Journal of Neuroinflammation. 2012, 9:32.
10. Chen SH, Wu HM, Ossola B, Schendzielorz N, Wilson BC, Chu CH, Chen SL, Wang Q, Zhang D, Qian L, Li X, Hong JS, Lu RB. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage. British Journal of Pharmacology. 2012, 165, 494-505.
11. Wang Q, Song F, Zhang C, Zhao X, Zhu Z, Yu S, Xie K. Carboxyl-terminus of Hsc70 interacting protein mediates 2,5-hexanedione-induced neurofilament medium chain degradation. Biochemical Pharmacology. 2011, 793-9.
12. Feng J#, Wang Q#, Chiang A, Chen BY. The effects of sleep hypoxia on coagulant factors and hepatic inflammation in emphysematous rats. PLoS One. 2010, 5: e13201.
学术兼职
EDITORIAL BOARD MEMBER
2013-present Journal of Toxins
2013-present Journal of Bioequivalence & Bioavailability
2013-present International Journal of Neuroscience and Behavioral Science
REVIEWER FOR JOURNALS
PloS One
Brain Research
NeuroToxicology
Toxicology in vitro
Neurotoxicology and Teratology
International journal of biological sciences
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