个人简介
张桂信
职务: 主任医师
专业: 普通外科学
Education/Working Experience
Education Experience
09/2006 – 07/2009 Ph.D. , Dalian Medical University, Dalian.
Specialty: Surgery of Integrated Traditional and Western Medicine
Project: The pathogenesis of acute biliary pancreatitis.
09/2003 – 07/2006 Master of Medicine, Dalian Medical University, Dalian.
Specialty: Surgery of Integrated Traditional and Western Medicine
05/2000 – 12/2004 Bachelor of Science, Self-study higher education examination, Liaoning Normal University, Dalian.
Specialty: Computer information management
09/1998 – 07/2003 Bachelor of Medicine, Department of Clinical Medicine, Dalian Medical University, Dalian, Liaoning province, China.
Specialty: Clinical Medicine
Professional Experience
10/2015 – present Vice Director, Chief Surgeon, Department of Acute Abdomen Surgery, The First Affiliated Hospital of Dalian Medical University, China.
10/2013 – present Supervisor of Postgraduate Student, General Surgery, The First Affiliated Hospital of Dalian Medical University, China.
12/2012 – 09/2015 Vice Chief Surgeon, Department of Acute Abdomen Surgery, The First Affiliated Hospital of Dalian Medical University, China.
10/2014 – 02/2015 Advanced Study, Department of Endoscopic minimally invasive surgery, Tianjin Nankai Hospital, China.
09/2010 – 11/2012 Attending Surgeon, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University.
10/2009 – 08/2010 Surgical Resident, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, China
10/2008 – 04/2009 Visiting Scholar, Institute of cell and molecular biology, University of South Florida, USA.
Research Projects/Grants
1、Influence of Qingyi decoction on pancreatic acinar cell Gpbar1 signal pathway in acute biliary pancreatitis in rat. National Science Foundation of China(81303110), 2014/01-2016/12，¥230,000.00,Director.
2、The mechanism of Qingyi decoction regulates the apoptosis and necrosis in pancreatic acinar cell in acute biliary pancreatitis. Basic Research Foundation of Liaoning Province Key Lab(LZ2015028), 2015/01-2017/12,¥200,000.00,Director.
3、Significance of transcription factor in pancreatic acinar injury induced by deoxycholic acid and the influence of Qingyi decoction. Doctoral program of the Ministry of education of China(20112105120007),2012/01-2014/12,¥80,000.00,Director.
4、Regulation mechanism of Gpbar1 and FXR in pancreatic acinar injury in acute biliary pancreatitis and the influence of Qingyi decoction. Research Foundation of Liaoning Province Education Department(L2012328),2011/01-2013/12,¥30,000.00,Director.
Admission Plan/Requirements
Recruit 1 foreign graduate student per year.
Major in biliary and pancreatic surgery, welcome the student who also interested in Traditional Chinese Medicine, and prefer English native speakers.
近期论文
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[1] Zhang JW, Zhang GX, Chen HL, et al. Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury. World J Gastroenterol. 2015. 21(12): 3537-46.
[2] Luo P, Wang C, Zhang G. A rare case report of chronic cholecystitis complicated with incomplete gallbladder volvulus. Int J Clin Exp Med. 2014. 7(10): 3602-4.
[3] Zhang G, Zhang J, Shang D, Qi B, Chen H. Deoxycholic acid inhibited proliferation and induced apoptosis and necrosis by regulating the activity of transcription factors in rat pancreatic acinar cell line AR42J. In Vitro Cell Dev Biol Anim. 2015 .
[4] Zhang G, Chen H, Cao C et. al.. Cytotoxic effect of desoxycholic acid on pancreatic acinar cells and its influence on the activity of nuclear transcription factors. Chin J Exp Surg. 2011. 28(9): 1512-1514.
[5] Zhang G, Zhang J, Shang D, Qi B, Chen H. Deoxycholic acid inhibited proliferation and induced apoptosis and necrosis by regulating the activity of transcription factors in rat pancreatic acinar cell line AR42J. In Vitro Cell Dev Biol Anim. 2015. 51(8): 851-6.
[6] Zhang GX, Chen HL, Ji J, Wu YY, Shang D, Zhang L. Emodin protects from deoxycholic acid-induced AR42J cell damage. Shijie Huaren Xiaohua Zazhi 2012; 20(9):771-775.
[7] Tan Y, Bi W, Zhang GX. Role and molecular mechanism of farnesoid X receptor in obstructive jaundice. Shijie Huaren Xiaohua Zazhi 2015; 23(16): 2574-2581.
[8] Qi B, Chen HL, Shang D, Dong Y, Zhang GX, Yu L. Effects of hypoxia-inducible factor-1alpha and matrix metalloproteinase-9 on alveolar-capillary barrier disruption and lung edema in rat models of severe acute pancreatitis-associated lung injury. Exp Ther Med. 2014. 8(3): 899-906.
[9] Zhang GX, Chen HL, Gong AX, Zhang L. Relationship between pancreatic acinar cell apoptosis and acute pancreatitis and the therapeutic strategy for acute pancreatitis. Shijie Huaren Xiaohua Zazhi 2007;15(10):1115-1120
[10] Chen HL, Zhang GX, Gong AX, Zhang L. Role of acinar cell apoptosis and expression of Bax and Caspase-8 in rats with acute Necrotizing pancreatitis. Shijie Huaren Xiaohua Zazhi 2007;15(10):1067-1072
[11] Zhang Guixin, Chen Hailong, Qu Shuxian, Gong Aixia. Effects of QingYiTang Decoction on Apoptosis of Acinar Cell in Rats with Acute Necrotizing Pancreatitis. Chinese Journal of Surgery of Integrated Traditional and Western Medicine 2008; 14: 38-42.
学术兼职
General Surgery Division of Chinese Association of Integrative Medicine
Digestion and nutrition Specialized Committee of Chinese Association for Physiological Sciences
Digestive Endoscopic Intervention Committee of Chinese Medical Doctor Association
General Surgery Division Association of Integrative Medicine of Liaoning Province
Acute Abdomen Surgery Committee of Medical Association of Liaoning Province
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