个人简介
董颖雪
职务: 医学博士
专业: 心律失常
Education/Working Experience
2009 – 2010 Reseach fellow, heart rhythm department
Mayo clinic, USA
Research Projects:
Engaged in the research on the cardiology, especially on thecardiac electrophysiology(EP).
a. pacemaker implanted, especially the temporary PM. Kinds of puncture techniques and leads placing during the ablation procedure. Patients management before and after of the intervention treatment. (2008-2009).
b. non-contact 3-dimensional mapping during linear ablation and circumferential isolation of pulmonary veins for atrial fibrillation and general electrophysio-
logic mapping.(2007-2008).
b. research on the topic: the impact of pulmonary vein isolation on atrial electrical remodeling(2006-2007).
c. the effect of vagal modulation on atrial fibrillation (2005-2006).
d. the histology mechanism of pulmonary vein isolation on atrial fibrillation(2005-2006).
c. clinical anticoagulation study on atrial fibrillation (the 10thfive-year-program for tackling key problems of China). (2003-2004)
2000 – 2001 Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Research Projects:
Hereditary studies on the familial long QT syndrome.
a. the gene mutation scan on congenital long QT syndrome.
b. functional analysis on the mutation gene.
c. Electric activity of cells recorded by whole-cell patch-
clamp techniques.
d. Designing optimal primers and optimizing the conditions for PCR and Real-Time PCR.
Research Direction
Heart Arrhythmia
Scientific Research Project
2012 The National Natural Science Foundation of China(NSFC)(No. 81200137)
1st applicant
2010 The Science and Technology Fund of Liaoning (No.20100125)
1st applicant
Title: impact of domain frequency ablation on atrial fibrillation
2007 The National Natural Science Fund of China (No.30770866)
2nd applicant
Title: experimental study of pulmonary vein isolation on vagal modulation and atrial electrical remodeling
2007 The Science and Technology Fund of Dalian (No.2007J23JH035)
2nd applicant
Title: mechanism study about the impact of CAFE ablation on atrial fibrillation
近期论文
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1. Dong YX, Madhavan M, Wu JH, Oh JK, Mitsuru M, Powell BD, Dong K, Yang YZ, Hodge DO, Nishimura RA, Packer DL, Borlaug BA, Cha YM.M. Acute effects of atrial fibrillation on atrial and ventricular function: A simultaneous invasive-echocardiographic hemodynamic study. Int J Cardiol. 2013 Int J Cardiol. 169(6):e114-9.
2. Dong YX, Boodhna J, Yang YZ. Effect of ventricular leads position on the clinic outcome of cardiac resynchronization therapy.Chin Med J (Engl). 2013 Aug;126(16):3161
3. Dong YX, Oh JK, Yang YZ, Cha YM. Left ventricular 12 segmental strain imaging predicts response to cardiac resynchronization therapy.Chin Med J (Engl). 2013 Jul;126(14):2620-4.
4. Munger TM, Dong YX, Masaki M, Oh JK, Mankad SV, Borlaug BA, Asirvatham SJ, Shen WK, Lee HC, Bielinski SJ, Hodge DO, Herges RM, Buescher TL, Wu JH, Ma C, Zhang Y, Chen PS, Packer DL, Cha YM.Electrophysiological and Hemodynamic Characteristics Associated With Obesity in Patients With Atrial Fibrillation.J Am Coll Cardiol. 2012，28;60(9):851-60.
5. Dong YX, Brian D. Powell, Samuel J. Asirvatham, Paul A. Friedman, Robert F. Rea, Tracy L. Webster, Kelly L. Brooke, David O. Hodge, Heather J. Wiste, Yan-zong Yang, David L. Hayes, Yong-Mei Cha. Left Ventricular Lead Position for Cardiac Resynchronization: A Comprehensive Cinegraphic, Echocardio- graphic, Clinical, and Survival Analysis. EUROPACE, 2012, 14(8):1139-47.
6. Dong YX, Burnett JC Jr, Chen HH, et al. Effect of cardiac resynchronization therapy on broad neurohormone biomarkers in heart failure. J Interv Card Electrophysiol. 2011;30(3):241-9.
7. Cha YM, Chareonthaitawee P, Dong YX, et al. Cardiac sympathetic reserve and response to cardiac resynchronization therapy. Circ Heart Fail. 2011;4(3):339-44.
8. Munger TM, Dong YX, Masaki M, Oh JK, Mankad SV, Borlaug BA, Asirvatham SJ, Shen WK, Lee HC, Bielinski SJ, Hodge DO, Herges RM, Buescher TL, Wu JH, Ma C, Zhang Y, Chen PS, Packer DL, Cha YM.Electrophysiological and Hemodynamic Characteristics Associated With Obesity in Patients With Atrial Fibrillation.J Am Coll Cardiol. 2012 Jun 7. [Epub ahead of print]
9. Dong YX, Powell BD, Asirvatham SJ, Friedman PA, Rea RF, Webster TL, Brooke KL, Hodge DO, Wiste HJ, Yang YZ, Hayes DL, Cha YM.Left ventricular lead position for cardiac resynchronization: a comprehensive cinegraphic, echocardiographic, clinical, and survival analysis. Europace. 2012 Mar 30. [Epub ahead of print]
10. Dong YX, Guo M, Yang YZ, Gao LJ, Cha YM, Xie ZZ, Zhang SL, Sun YH, Wang YQ, Xia YL, Boodhna J.[Effects of ventricular demand and dual-chamber pacing models on the long-term clinical outcome and cardiac remodeling in patients with symptomatic bradycardia].Zhonghua Yi Xue Za Zhi. 2011 Aug 16;91(30):2103-7
11. Dong K, Shen WK, Powell BD, Dong YX, et al. Atrioventricular nodal ablation predicts survival benefit in patients with atrial fibrillation receiving cardiac resynchronization therapy.Heart Rhythm. 2010 Sep;7(9):1240-5.
12. Dong YX, Cha Yongmei. State of the art cardiac resynchronization therapy: where we are and further direction. National medical journal of China. 2010,25,90(20):1371-4.
13. ZHANG Shu-long, DONG Ying-xue, JIANG Peng, GAO Lian-jun, CHA Yong-mei, Douglas L. Packer, XIA Yun-long, YIN Xiao-meng, CHANG Dong and YANG Yan-zong. Effect of ablation of complex fractionated atrial electrogram on vagal modulation in dogs. Chinese medical Journal(Egl), 2010, 123(22), in print.
14. Ying-xue Dong, Yong-mei Cha. Arrhythmogenic mechanism for the sudden death in heart failure. Journal of Geriatric Cardiology, 2009.16(4):244-248.
15. Dong K, Shen WK, Powell BD, Dong YX, et al. Atrioventricular nodal ablation predicts survival benefit in patients with atrial fibrillation receiving cardiac resynchronization therapy. Heart Rhythm. 2010, 7(9):1240-5.
16. Dong YX, Zhang SL, Gao LJ, Yang YZ. New insight on Atrial flutter. Chinese Journal of Postgraduates of Medicine,，2009, 32（33）:74-75.
17. Wokhlu A, Rea RF, Asirvatham SJ, Webster T, Brooke K, Hodge DO, Wiste HJ, Dong Y, Hayes DL, Cha YM. Upgrade and de novo cardiac resynchronization therapy: impact of paced or intrinsic QRS morphology on outcomes and survival. Heart Rhythm. 2009, 6(10):1439-47.
18. Dong YX, Zhang SL, Gao LJ, Yang YZ. Impact of Pulmonary Veins Isolation on Atrial vagal Activity and Atrial Electrical Remodeling, Journal of Geriatric Cardiology，2008,5(1), 28-32.
19. Dong yingxue, Gao lianjun, Zhang shulong, et al. Pulmonary vein occlusion and remodeling after electrical isolation treatment for atrial fibrillation. Chinese medical Journal(Egl), 2005, 118(14): 1125-1126.
20. Liu Y, Zhang SL, Dong YX, et al. Impact of right upper pulmonary vein isolation on atrial vagal innervation and vulnerability to atrial fibrillation. Chin Med J (Engl). 2006, 119(24): 2049-2055.
21. Teng S, Ma L, Dong Y, et al. Clinical and electrophysiological characterization of a novel mutation R863X in HERG C-terminus associated with long QT syndrome. J Mol Med. 2004, 82(3):189-196.
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