个人简介
刘晶
职务: 主任
专业: 再生医学
Education/Working Experience
2007-2008 Oxford University Post-doctoral research
Research Direction
Stem cell technology and neural regeneration
Scientific Research Project
1.General Program of National Natural Science Foundation of China:Rebuild functional dopaminergic neural networks of PD model by controllable factor releasing 3 dimensional scaffold combining with target decorated AMSCs.2013-2016
2.Granted Advanced Program for Returned Overseas Researchers fromMinistry of Human Resources and Social Security: Developing the key technology for organ-specific stem cells implantation scaffold and directional growth and differentiation.2013-2015
3. Dalian Science and Technology project: Key technology research and development of human organic stem cell and tissue engineering. 2012-2014
4. General Program of National Natural Science Foundation of China: Construction of functional dopaminergic neural networks by 3D co-culture of hBMSCs/ dopaminergic neural in black substance with stratified microbial reactor irrigator. 2011-2013
5. Livelihood science and technology project of Dalian science and technology Bureau: The key technology Development for organ-specific stem cells implantation scaffold and directional growth and differentiation.2011-2013
6.Scientific Research Foundation for Returned Overseas Researchersfrom Ministry of Education: Dynamics of synapses structure during the neural differentiation of human marrow mesenchymal stem cells by 3D perfusing culture. 2010-2012
7.International cooperation project of Dalian Science and Technology Bureau:
Build up Sino-UK clinical application and technology platform of stem cells. 2010-2012
8.Ph.D. Programs foundations of LiaoningScience and Technology Agency: The optimization program screening and neural network model building of BMSC neural differentiation by 3D perfusing culture. 2010-2012
9. National Science and Technology Cooperation Program of Ministry of Science and Technology: core technology introduction and joint research with Russian of organ-specific stem cells transplantation and orientated growth and differentiation. 2010-2012
10. UK, [EPSRC]: Development of a smart bioreactor for mammalian adherent cell expansion for application to cell therapy. Cooperator, 2009-2010
近期论文
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1) Human Adipose-derived Mesenchymal Stem Cells: A Better Cell Source for Nervous System Diseases Application. Chinese Medical Journal.2014,127(2): 1-10
2) Effects of vitexin-2″-O-rhamnoside and vitexin-4″-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells. The Journal of Pharmacy and Pharmacology, 2014, in press
3) Rat cortex and hippocampus-derived soluble factors for the induction of adipose-derived mesenchymal stem cells into neuron-like cells. Cell Biology International, 2014 Feb 6. doi: 10.1002/cbin.10256
4) Synthetic nucleic acids delivered by exosomes: a potential therapeutic for gene-related metabolic brain diseases. Metabolic Brain Disease. 2013, 28(4):551 - 562
5) A novel approach to facilitate dopaminergic neuron generation from stem-cells: the combination of genetic modification and signaling factors within a three-dimensional perfusion microbioreactor. Med Hypotheses. 2013，80：407-410.
6) Caveolin-1, through Its Ability to Negatively Regulate TLR4, is a Crucial Determinant of MAPK Activation in LPS-challenged Mammary Epithelial Cells. Asian Pacific Jorunal of Cancer Prevention. 14(2013) 2295-2299.
7) Application of multiple parallel perfused microbioreactors: Synthesis characterization and cytoxicity testing of the novel rare earth complexes with indole acid as a ligand.Journal of Inorganic Biochemistry 128 (2013) 57–67.
8) Exosomes: the novel vehicles for intercellular communication. Progress in Biochemistry and Biophysics. 2013, 40(8):719-727.
9) Protective Effect of Phosphatidylcholine on Restoration of Ethanol-Injured Hepatocytes related with Caveolin-1.Journal of Membrane Biology, 2013. DOI 10.1007/s00232-013-9613-0.
10) Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats. Neural Regeneration Research, 2013;8(29):2725-2733
11) Electrophysiological Properties and Synaptic Function of Mesenchymal Stem Cells during Neurogenic Differentiation. The International Journal of Artificial Organs. Int J Artif Organs, 2012, 35(5): 323-37.
12) Design of Stem Cell Therapy Facility (MS number 520). Comprehensive Biotechnology, 2011,2e (the 5Work”) edited by Murray Moo-Young , 443-454, 2011（ELSEVIER B.V.）
13) Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats. Brain Research. 1123(2006) 68-79
14) Conditioned medium of human adipose-derived mesenchymal stem cells mediates protection in neurons following glutamate excitotoxicity by regulating energy metabolism and GAP-43 expression. Metabolic Brain Disease. DOI 10.1007/s11011-014-9490-y.
15) A New Oxovanadium Complex Enhances Renal Function by Improving Insulin Signaling Pathway in Diabetic Mice.Journal of Diabetes and Its Complications.10.1016/j.jdiacomp.2014.02.001
16) Relationship between spatial memory in diabetic rats and protein kinase Cγ, caveolin-1 in the hippocampus and neuroprotective effect of catalpol. Chin Med J, 2014, 127(5):916-23.
学术兼职
Oxford Stem Cell Institute
Liaoning Society for Immunology
Liaoning Society for Cell Biology and Neural Regeneration
Dalian Society for Cell Therapy Quality Control
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