研究领域

Organic Chemistry

My role in the CRL is as the Director of NMR Spectroscopy for Organic Chemistry & Chemical Biology which means I am responsible for managing the core NMR facilities, services and support staff. I am also an associate professor and my research interests revolve around the application of solution-state NMR techniques to address questions of structure, function and dynamics of "small" molecules in organic chemistry and chemical biology. Many of the projects in which I become involved arise through collaborations with groups across the Department, with examples summarised below.

近期论文

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High-Resolution NMR Techniques in Organic Chemistry. 2nd Edition T. D. W. Claridge, Elsevier Science, Oxford, 2009. TOCSY T. D. W. Claridge, in Multidimensional NMR Methods for the Solution State, (Eds. G. A. Morris and J. W. Emsley), John Wiley & Sons Ltd, Chichester, 2010. Monitoring conformational changes in the NDM-1 Metallo-β-lactamase by 19F NMR Anna M. Rydzik, Jürgen Brem, Sander S. van Berkel, Inga Pfeffer, Anne Makena, Timothy D. W. Claridge, Christopher J. Schofield, Angew. Chem. Int. Ed. Engl., 2014, 53, 3129-3133 Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications. Anna M. Rydzik, Ivanhoe K. H. Leung, Armin Thalhammer, Grazyna T. Kochan, Timothy D. W. Claridge and Christopher J. Schofield, Chem. Commun., 2014, 50, 1175-1177 ​ A Discrete Three-Layer Stack Aggregate of a Linear Porphyrin Tetramer: Solution-Phase Structure Elucidation by NMR and X-Ray Scattering. Marie Hutin, Johannes K. Sprafke, Barbara Odell, Harry L. Anderson and Tim D. W. Claridge, J. Am. Chem. Soc., 2013, 135, 12798−12807. Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors Ivanhoe K. H. Leung, Marina Demetriades, Adam P. Hardy, Clarisse Lejeune, Tristan J. Smart, Andrea Szöllössi, Akane Kawamura, Christopher J. Schofield, Timothy D. W. Claridge, J. Med. Chem., 2013, 56, 547-555. ​ Conformational analysis of fluorinated pyrrolidines using 19F-1H scalar couplings and heteronuclear nOes ​Lorraine E. Combettes, Philip Clausen-Thue, Mike King, Barbara Odell, Amber L. Thompson, Véronique Gouverneur, and Tim D. W. Claridge, Chem. Eur. J, 2012, 18, 13133-13141​ An approach to enzyme inhibition employing reversible boronate ester formation Ivanhoe K. H. Leung, Tom Brown Jr, Christopher J. Schofield, Timothy D. W. Claridge., Med. Chem. Comm., 2011, 2, 390-395. ​ Using NMR Solvent Relaxation to Investigate Metalloenzyme-Ligand Binding Interactions Ivanhoe K. H. Leung, Emily Flashman, Kar Kheng Yeoh, Christopher J. Schofield and Timothy D. W. Claridge, J. Med. Chem., 2010, 53, 867-875. Group epitope mapping considering relaxation of the ligand (GEM-CRL): Including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments Sebastian Kemper, Mitul K. Patel, James C. Errey, Benjamin G. Davis, Jonathan A. Jones, Timothy D. W. Claridge, J. Magn. Reson., 2010, 203, 1-10. Monitoring the Activity of 2-Oxoglutarate Dependent Histone Demethylases by NMR Spectroscopy: Direct Observation of Formaldehyde Richard J. Hopkinson, Refaat B. Hamed, Nathan R. Rose, Timothy D. W. Claridge, and Christopher J. Schofield, ChemBioChem, 2010, 11, 506-510. Studies on the reaction of glutathione and formaldehyde using NMR Richard J. Hopkinson, Philippa S. Barlow, Christopher J. Schofield and Timothy D. W. Claridge, Org. Biomol. Chem., 2010, 8, 4915-4920. Saturation Transfer Difference NMR reveals functionally essential kinetic differences for a sugar binding repressor protein Ignacio Pérez-Victoria, Sebastian Kemper, Mitul K. Patel, John Edwards, James C. Errey, Lucia F. Primavesi, Matthew J. Paul, Timothy D. W. Claridge, and Benjamin G. Davis, Chem. Comm., 2009, 5862-5864