江昀緯 - 台湾清华大学

个人简介

學歷：美國康乃爾大學博士 (2006) 美國康乃爾大學碩士 (2001) 國立中山大學學士 (1998) 經歷： 2017~國立清華大學教授 2015~ 國立清華大學化學系副主任 2012~2017國立清華大學副教授 2007~2012國立清華大學助理教授 2006~2007博士後研究：美國康乃爾大學 (2006~2007) 本實驗室從事跨領域研究，主旨在於發展、利用尖端的光譜磁共振與螢光顯微鏡技術解析電子與原子核之間各種作用力，進而在分子層次具體描述生物巨分子、分子聚合體的動力學反應與行為；同時進行生物醫學的分析與應用。本實驗室研究同時涵蓋實驗與理論工作，目前研究課題包括： 1) Biological molecules in nano-scale space of nanomaterials。 2) Dynamic structures of water clusters and confined water。 3) Biophysics of Apoptosis。 4) Quantum statistical mechanics for ESR spectroscopy。

研究领域

物理化學，電子自旋共振（ESR），生物物理化學，凝態物理，生醫分析;

近期论文

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A. Biophysics/Chemical Biology/Apoptosis research A1. TC Sung, CY Li, YC Lai, CL Hung, O Shih, YQYeh, US Jeng, and YW Chiang*, Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion, STRUCTURE, 23 (2015) 1878-1888. A2. CH Chan, CJ Tsai, and YW Chiang*, Side-chain Packing Interactions Stabilize an Intermediate of BAX Protein Against Chemical and Thermal Denaturation, Journal of Physical Chemistry B, 119 (2015) 54-64. A3. CJ Tsai, S Liu, CL Hung, SR Jhong, TC Sung, and YW Chiang*, BAX-induced Apoptosis Can Be Initiated Through A Conformational Selection Mechanism, STRUCTURE, 23 (2015) 139-148. (selected as a featured article) B. Physical Chemistry/Nanochannels/Water Dynamics B1. C Yang, WL Lo, YH Kuo, J C Sang, CY Lee, YW Chiang*, and Rita PY Chen*, Revealing structural changes of prion protein during conversion from α-helical monomer to β-oligomers by means of ESR and nanochannel encapsulation, ACS Chemical Biology, 10 (2015) 493-501. B2. YH Kuo, YR. Tseng, and YW Chiang*, Concurrent Observation of Bulk and Protein Hydration Water by Spin-Label ESR under Nanoconfinement, Langmuir, 29 (2013) 13865-13872. B3. YC Lai, YF Chen, and YW Chiang*, ESR Study of Interfacial Hydration Layers of Polypeptides in Water-Filled Nanochannels and in Vitrified Bulk Solvents, PLoS ONE, 8 (2013) e68264-13. B4. CJ Tsai, and YW Chiang*, Effects of Anisotropic Nanoconfinement on Rotational Dynamics of Biomolecules: An Electron Spin Resonance Study, Journal of Physical Chemistry C, 116 (2012) 19798-19806. B5. YW Huang, and YW Chiang*, Spin-label ESR with Nanochannels to Improve the Study of Backbone Dynamics and Structural Conformations of Polypeptides, Physical Chemistry Chemical Physics, 13 (2011) 17521-17531. B6. YW Huang, YC Lai, CJ Tsai, and YW Chiang*, Mesopores Provide an Amorphous State Suitable for Studying Biomolecular Structure at Cryogenic Temperatures, Proceedings of the National Academy of Sciences (PNAS), 108 (2011) 14145-14150. B7. TC Sung, and YW Chiang*, Identification of Complex Dynamic Modes on Prion Protein Peptides Using Multifrequency ESR with Mesoporous Materials, Physical Chemistry Chemical Physics, 12 (2010) 13117-13125. C. ESR Analysis/Theory C1. YW Chiang, AJ Costa-Filho, B Baird, and JH Freed*, 2D-ELDOR Study of Heterogeneity and Domain Structure Changes in Plasma Membrane Vesicles Upon Crosslinking of IgE Receptors, Journal of Physical Chemistry B, 115 (2011) 10462-10469. C2. YW Chiang*, JH Freed*, A New Lanczos-Based Algorithm for Simulating High-Frequency Two-dimensional ESR Spectra, (2010) Journal of Chemical Physics, 134 (2011) 034112-10. C3. YW Chiang*, TY Zheng, CJ Kao, JC Horng, Determination of Interspin Distance Distributions by CW-ESR Is A Single Linear Inverse Problem, Biophysical Journal, 97 (2009) 930-936. C4. YW Chiang, PP Borbat, JH Freed*, The Determination of Pair Distance Distributions by Pulsed ESR Using Tikhonov Regularization, Journal of Magnetic Resonance, 172 (2005) 279-295. D. Inorganic/Materials D1. WC Shih, TT Lu, LB Yang, FT Tsai, MH Chiang, JF Lee, YW Chiang, WF Liaw*, New members of a class of dinitrosyliron complexes (DNICs): The characteristic EPR signal of the six-coordinate and five-coordinate {Fe(NO)2}9 DNICs, Journal of Inorganic Biochemistry, 113 (2012) 83-93. D2. QB Nguyen, CL Chen, YW Chiang, and KH Lii*, Cs3UGe7O18: A Pentavalent Uranium Germanate Containing Four- and Six-Coordinate Germanium, Inorganic Chemistry, 51 (2012) 3879-3882. D3. HL Huang, YC Lai, YW Chiang, and SL Wang* Intrinsic Optical Properties and Divergent Doping Effects of Manganese(II) on Luminescence for Tin(II) Phosphite Grown from a Deep-Eutectic Solvent, Inorganic Chemistry, 51 (2012) 1986-1988. D4. LH Huang, YC Lai, HC Lai, YW Chiang, J-H Huang and SL Wang* The First Organic-Templated Vanadyl(IV) Gallophosphates with Ambient 51V Hyperfine Structure, {V2Ga2O14} Cluster or Heterometal 12-Ring Channels, Inorganic Chemistry, 48 (2009) 11882-11888.