Burton, Jonathan - University of Oxford

个人简介

Jonathan Burton is Professor of Organic Chemistry and a Tutorial Fellow at Somerville College. He heads-up a research group working on numerous aspects of organic synthesis, methodology, reactivity, and structure determination. Jonathan began his independent research career as a Royal Society University Research Fellow at the University of Cambridge (2000-2006) before moving to Oxford in 2007. Before this he was a Post-Doctoral Research Fellow at Cambridge with Andrew Holmes (methodology and natural product synthesis) and a Post-Doctoral researcher with Alex Alexakis in Paris (enantioselective catalysis). He obtained his B.A. (Chemistry) from the University of Oxford and his Ph.D. from the University of Cambridge working with Andrew Holmes on medium-ring ether natural products.

研究领域

Our research interests are as follows: total synthesis, structure determination and methods development. We are interested in: the development of key reaction methodology, especially in the areas of oxidative radical cyclisations and transition metal catalysed processes; all aspects of the structure and conformational preferences of ring compounds; and the use of biosynthesis and computational methods as predictive tools for the structure determination of complex molecules. All of the above inform and guide our research on complex molecule total synthesis.

近期论文

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ORG. LETT. 2022, 24, 50, 9174–9178 Total Synthesis and Structure Confirmation of (E) and (Z)-Ocellenyne Hicks, H. B.; Brown, D. S.; Chan, H. S. S.; Sousa, B. A.; Christensen, K. E.; Burton, J. W. ADV. SYNTH. CATAL. 2022, 364, 1724 Transition Metal-Free, Visible Light-Mediated Radical Cyclisation of Malonyl Radicals onto 5-Ring Heteroaromatics Hernández-Lladó, P.; Garrec, K. ; Schmitt, D. C.; Burton, J. W. CHEM. SCI., 2020,11, 11592-11600 Forwards and backwards – synthesis of Laurencia natural products using a biomimetic and retrobiomimetic strategy incorporating structural reassignment of laurefurenynes C–F Chan, H. S. S.; Thompson, A. L.; Christensen, K. E.; Burton, J. W. EUR. J. ORG. CHEM. 2020 (18), 2766–2770 Organophotochemical SNAr Reactions of Mildly Electron-Poor Fluoroarenes Sheridan, T.; Yayla, H. G.; Lian, Y.; Genovino, J.; Monck, N.; Burton, J. W. TETRAHEDRON 2020, 76 (11) Synthesis of the Cyclopentane Core of Pepluanin A Shepherd, E. D.; Hallside, M. S.; Sutro, J. L.; Thompson, A.; Hutchings, M.; Burton, J. W. J. AM. CHEM. SOC. 2019, 141, 40, 15951–159 Synthesis, Characterization, and Reactivity of Complex Tricyclic Oxonium Ions, Proposed Intermediates in Natural Product Biosynthesis Chan, H. S. S.; Nguyen, Q. N. N.; Paton, R. S.; Burton, J. W. J. ORG. CHEM. 2019, 84, 9, 4971–4991 Structure Determination of a Chloroenyne from Laurencia majuscula Using Computational Methods and Total Synthesis Shepherd, E. D.; Dyson, B. S.; Hak, W. E.; Nguyen, Q. N. N.; Lee, M.; Kim, M. J.; Sohn, T.; Kim, D.; Burton, J. W.; Paton, R. S. J. CHEM. EDUC. 2019, 96, 1, 137–142 Four Step Total Synthesis of an H3 Receptor Antagonist Using Only Tools Found in a Typical Teaching Laboratory Smith, C. J.; Mansfield, S. J.; Anderson, E. A.; Burton, J. W. CHEM. EUR.J.2018, 24,16753 –16756 Short, Tin‐Free Synthesis of All Three Inthomycins Kumar, M.; Bromhead, L.; Anderson, Z.; Overy, A.; Burton, J. W. TETRAHEDRON 74 (2018) 5012 –5021 Short total syntheses of the avenaciolide family of natural products Martinez, S. A.; Gillard, M.; Chany, A.-C.; Burton, J. W. CHEM. EUR.J.2018, 24,6747 –6754 A Total Synthesis of Salinosporamide A Marx, L. B.; Burton, J. W. CHEM. EUR.J.2016, 22,11597 –11600 A Short Synthesis of Aphanamol I in Both Racemic and Enantiopure Forms Ferrara, S. J.; Burton, J. W. SYNLETT 2016, 27, 919–923 Synthesis of Novel Amino Acids Containing Cubane Wlochal, J.; Davies, R. D. M.; Burton, J. W. ORG. BIOMOL. CHEM., 2015, 13, 9190–9193 Synthesis of bicyclic tetrahydrofurans from linear precursors using manganese(III) acetate Chany, A.-C.; Marx, L. B.; Burton, J. W. ORG. LETT. 2014, 16 (16), 4094–4097 Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks Wlochal, J.; Davies, R. D. M.; Burton, J. W. ORG. LETT. 2014, 16 (16), 4078–4081 Diastereoselective Synthesis of Fused Lactone-Pyrrolidinones; Application to a Formal Synthesis of (-)-Salinosporamide A Logan, A. W. J.; Sprague, S. J.; Foster, R. W.; Marx, L. B.; Garzya, V.; Hallside, M. S.; Thompson, A. L.; Burton, J. W. CHEM. EUR. J. 2013, 19 (38), 12644–12648 Structure Reassignment of Laurefurenynes A and B by Computation and Total Synthesis Shepherd, D. J.; Broadwith, P. A.; Dyson, B. S.; Paton, R. S.; Burton, J. W. J. AM. CHEM. SOC. 2012, 134 (28), 11781–11790 Total Synthesis and Structure Confirmation of Elatenyne: Success of Computational Methods for NMR Prediction with Highly Flexible Diastereomers Dyson, B. S.; Burton, J. W.; Sohn, T.; Kim, B.; Bae, H.; Kim, D. ORG. LETT. 2012, 14 (12), 2940–2943 Manganese(III) Acetate Mediated Oxidative Radical Cyclizations. Toward Vicinal All-Carbon Quaternary Stereocenters Logan, A. W. J.; Parker, J. S.; Hallside, M. S.; Burton, J. W. CHEM. COMMUN. 2012, 48 (52), 6496–6498 Manganese(III)-Mediated Radical Cyclisations for the (Z)-Selective Synthesis of Exo-Alkylidene Pyrrolidinones and Pyrrolidines Keane, H. A.; Hess, W.; Burton, J. W.