Brown, Tom - University of Oxford - Department of Chemistry

研究领域

My research is in Nucleic acid chemistry, DNA sequence recognition and application of nucleic acids to nanotechnology, diagnostics and biology. It has produced 300 publications, several patents and 3 start-up companies. My Professorial position at Oxford University is a joint initiative between Chemistry and Oncology.

近期论文

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Azide and trans-Cyclooctene dUTPs: Incorporation into DNA Probes and Fluorescent Click-Labelling T. Brown, X. Ren and A. H. El-Sagheer. Analyst 2015. Reversible Energy-Transfer Switching on a DNA Scaffold M. Bälter, M. Hammarson, P. Remón, S. Li, N. Gale, T. Brown and J. Andréasson. J. Am. Chem. Soc. 2015. Highly Sensitive DNA Sensor Based on Upconversion Nanoparticles and Graphene Oxide P. Alonso-Cristobal, P. Vilela, A. H. El-Sagheer, E. Lopez-Cabarcos, T. Brown, O. L. Muskens, J. Rubio-Retama and A. G. Kanaras. ACS Appl. Mater. Interfaces 2015. Strain discrimination of Yersinia pestis using a SERS-based electrochemically driven melting curve analysis of variable number tandem repeat sequences E. Papadopoulou, N. Gale, S. A. Goodchild, D. W. Cleary, S. A. Weller, T. Brown and P. N. Bartlett. Chem. Sci. 2015. Using Surface-Enhanced Raman Spectroscopy and Electrochemically Driven Melting to Discriminate Yersinia pestis from Y. pseudotuberculosis Based on Single Nucleotide Polymorphisms within Unpurified Polymerase Chain Reaction Amplicons E. Papadopoulou, S. A. Goodchild, D. W. Cleary, S. A. Weller, N. Gale, M. R. Stubberfield, T. Brown and P. N. Bartlett. Anal. Chem. 87 (3), 1605-1612, 2015. Rapid detection of diagnostic targets using isothermal amplification and HyBeacon probes – A homogenous system for sequence-specific detection R. L. Howard, D. J. French, J. A. Richardson, C. E. O'Neill, M. P. Andreou, T. Brown, D. Clark, I. N. Clarke, J. W. Holloway, P. Marsh and P. G. Debenham. Mol. Cell. Probes 2015. Enhanced H-bonding and pi-stacking in DNA: A potent duplex-stabilizing and mismatch sensing nucleobase analogue C. Lou, A. Dallmann, P. Marafini, R. Gao and T. Brown. Chem. Sci. 5 (10), 3836-3844, 2014. Enzymatic Incorporation and Fluorescent Labelling of Cyclooctyne-Modified Deoxyuridine Triphosphates in DNA X. Ren, M. Gerowska, A. H. El-Sagheer and T. Brown. Bioorg. Med. Chem. 2014. Reverse transcription through a bulky triazole linkage in RNA: implications for RNA sequencing X. Chen, A. H. El-Sagheer and T. Brown. Chem. Commun. 50, 7597-7600, 2014. Force-induced melting of DNA—evidence for peeling and internal melting from force spectra on short synthetic duplex sequences N. Bosaeus, A. H. El-Sagheer, T. Brown, B. Akerman and B. Norden. Nucleic Acids Res. 42 (12), 8083-8091, 2014. A Mutant of Uracil DNA Glycosylase That Distinguishes between Cytosine and 5-Methylcytosine S. T. Kimber, T. Brown and K. R. Fox. PLOS ONE 2014. Functionalizing Designer DNA Crystals with a Triple-Helical Veneer D. A. Rusling, A. R. Chandrasekaran, Y. P. Ohayon, T. Brown, K. R. Fox, R. Sha, C. Mao, N. C. Seeman. Angew. Chem. Int. Ed. 53 (15), 3979-3982, 2014. Transcription of Click-Linked DNA in Human Cells C. N. Birts, A. P. Sanzone, A. H. El-Sagheer, J. P. Blaydes, T. Brown and A. Tavassoli. Angew. Chem. Int. Ed. 53 (9), 2362-2365, 2014. Self-reporting hybridisation assay for miRNA analysis J. Riley, T. Brown, N. Gale, J. Herniman and G. J. Langley. Analyst 139, 1088-1092, 2014. Structural insights into how 5-hydroxymethylation influences transcription factor binding L. Lercher, M. A. McDonough, A. H. El-Sagheer, A. Thalhammer, S. Kriaucionis, T. Brown and C. J. Schofield. Chem. Commun. 50, 1794-1796, 2014. Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility A. H. El-Sagheer and T. Brown. Chem. Sci. 5, 253-259, 2014. Triplex-mediated analysis of cytosine methylation at CpA sites in DNA M. W. Johannsen, S. R. Gerrard, T. Melvin and T. Brown. Chem. Commun. 50, 551-553, 2014. Measurement of a Reaction-Diffusion Crossover in Exciton-Exciton Recombination inside Carbon Nanotubes Using Femtosecond Optical Absorption J. Allam, M. T. Sajjad, R. Sutton, K. Litvinenko, Z. Wang, S. Siddique, Q.-H. Yang, W. H. Loh and T. Brown. Phys. Rev. Lett. 111, 197401, 2013.