Piggott, Andrew - Macquarie University - Department of Chemistry and Biomolecular Sciences

个人简介

Qualifications BMedScs(Hons), Macquarie University PhD, Macquarie University

研究领域

Discovery and development of next-generation antibiotics Natural product mode of action Biodiscovery and structure elucidation Chemical biology using natural product probes

近期论文

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Raju, R., Khalil, Z., Piggott, A.M., Blumenthal, A., Gardiner, D.L., Skinner-Adams, T.S., Capon, R.J. 'Mollemycin A: An Antimalarial and Antibacterial Glyco-hexadepsipeptide-polyketide from an Australian Marine-Derived Streptomyces sp. (CMB-M0244)', Org. Lett., 2014, 16, 1716-1719. Wang, Q., ... Piggott, A.M., Zhang, L. et al. 'Abyssomicins from the South China Sea Deep-Sea Sediment Verrucosispora sp.: Natural Thioether Michael Addition Adducts as Antitubercular Prodrugs', Angew. Chem. Int. Ed., 2013, 52, 1231-1234. Cho, K.-J., Park, J.-H., Piggott, A.M., Salim, A.A., Gorfe, A., Capon, R.J., Lacey, E. and Hancock, J.F. 'Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins', J. Biol. Chem., 2012, 287, 43573-43584. Köhnke, M., Schmitt, S., Ariotti, N., Piggott, A.M., Parton, R.G., Lacey, E., Capon, R.J., Alexandrov, K. and Abankwa, D. 'Design and Application of in vivo FRET Biosensors to Identify Protein Prenylation and Nanoclustering Inhibitors', Chem. Biol., 2012, 19, 866-874. Plisson, F., Conte, M., Khalil, Z., Huang, X.C., Piggott, A.M. and Capon, R.J. 'Kinase inhibitor scaffolds against neurodegenerative diseases from a Southern Australian ascidian, Didemnum sp.', ChemMedChem, 2012, 7, 983-990. Raju, R., Piggott, A.M., Barrientos Diaz, L.X., Khalil, Z.G. and Capon, R.J. 'Heronapyrroles A-C: Farnesylated 2-Nitropyrroles from an Australian Marine-Derived Streptomyces sp.', Org. Lett., 2010, 12, 5158-5161. Raju, R., Piggott, A.M., Conte, M.M. and Capon, R.J. 'Heronamides A-C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electro-cyclization', Org. Biomol. Chem., 2010, 8, 4682-4689. Balansa, W., Islam, R., Fontaine, F., Piggott, A.M., Zhang, H., Webb, T.I., Gilbert, D., Lynch, J.W. and Capon, R.J. 'Ircinialactams: Subunit-Selective Glycine Receptor Modulators from Australian Sponges of the Family Irciniidae', Bioorg. Med. Chem., 2010, 18, 2912-2919. Raju, R., Piggott, A.M., Conte, M., Tnimov, Z., Alexandrov, K. and Capon, R.J.