Paulsen, Ian - Macquarie University - Department of Chemistry and Biomolecular Sciences

个人简介

An expert in genomics, Ian worked for several years as an investigator for the Institute for Genomic Research in the US, where he led the sequencing of many microbial genomes. He is an ISI Highly Cited Researcher and holds a NSW Life Science Research Award at Macquarie. Ian is currently using genome sequencing, metagenomics and functional genomics to understand how lateral gene transfer in bacteria enables them to adapt to different environmental niches Research interests: Understanding microbial physiology and evolution through global approaches such as genome sequencing, metagenomics, bioinformatics, transcriptomics and proteomics.

研究领域

My research interests have focused on understanding microbial physiology and evolution, by utilising "big picture" or global approaches such as genome sequencing, transcriptomics, proteomics and phenomics in combination with established molecular biology and biochemistry techniques. Visit my blogspot for updates but the themes of my research are: Genome diversity, metagenomics and lateral gene transfer System biology analysis of membrane transport and metabolism Applying Genomics to Medicine Marine Microbiology Synthetic Biology

近期论文

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Hassan, K. A., Liu, Q., Henderson, P. J., and Paulsen, I. T. (2015) Homologs of the Actinobacter baumannii AceI transporter represent a new family of bacterial multidrug efflux systems. MBio. 6: e01982-14. Pérez-Bercoff, Å., Papanicolaou, A., Ramsperger, M., Kaur, J., Patel, H. R., Harun, A., Duan, S. Y., Elbourne, L., Bouchara, J. P., Paulsen, I. T., Nevalainen, H., Meyer, W., and Huttley, G. A. (2015) Draft Genome of Australian environmental strain WM 09.24 of the opportunisitc human pathogen Scedosporium aurantiacum. Genome Announcements 3: e01526-14. Kamath, K. S., Kumar, S. S., Kaur, J., Venkatakrishnan, V., Paulsen, I. T., Nevalainen, H., Molloy, M. P., (2015) Proteomics of host and pathogen in cystic fibrosis. Proteomics Clinical Applications 9: 134-46. Song, C., van der Voort, M., van de Mortel, J., Hassan, K. A., Elbourne, L. D., Paulsen, I. T., Loper, J. E., Raaijmakers, J. M. (2014) The Rsm regulon of plant growth-promoting Pseudomonas fluorescens SS101: role of small RNAs in regulation of lipopeptide biosynthesis. Microbial Biotechnology [Epub ahead of print] Myers, G. S., Parker, D., Al-Hasani, K., Kennan, R. M., Seemann, T., Ren, Q., Badger, J. H., Selengut, J. D., Deboy, R. T., Tettelin, H., Boyce, J. D., McCarl, V. P., Han, X., Nelson, W. C., Madupu, R., Mohamoud, Y., Holley, T., Fedorova, N., Khouri, H., Bottomley, S. P., Whittington, R. J., Adler, B., Songer, J. G., Rood, J. I, and Paulsen, I. T. (2007) Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus. Nature Biotechnology 25:569-575. Ren, Q., Chen, K., and Paulsen, I. T. (2007) TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Nucleic Acids Research 35: D274-279. Palenik, B., Ren, Q., Dupont, C. L., Myers, G. S., Heidelberg, J. F., Badger, J. H., Madupu, R., Nelson, W. C., Brinkac, L. M., Dodson, R. J., Durkin, A. S., Daugherty, S. C., Sullivan, S. A., Khouri, H., Mahamoud, Y., Halpin, R., and Paulsen, I. T. (2006) Genome sequence of Synechococcus CC9311: Insights into adaptation to a coastal environment. Proceedings of the National Academy of Sciences, USA 103: 13555-13559. Myers, G. S. A, Rasko, D. A., Cheung, J., Ravel, J., Seshadri, R., DeBoy, R., Varga, J., Awad, M., Brinkac, L., Daugherty, S., Dodson, B., Madupu, R., Nelson, W., Rosovitz, M. J., Sullivan, S., Khouri, H., Dimitrov, G., Watkins, K., Mulligan, S., Benton, J., Fisher, D. J., Atkins, H. S., Hiscox, T., Jost, H., Billington, S., Songer, J. G., McClane, B. A., Titball, R. W., Rood, J. I., Melville, S., and Paulsen, I. T. (2006) Skewed distribution of genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Research 16: 1031-1040. Ding, X. Z., Paulsen, I. T., Bhattacharjee, A., Nikolich, M. P., Myers, G. and Hoover, D. L. (2006) A high efficiency cloning and expression system for proteomic analysis. Proteomics 6: 4038-4044. Keseler, I. M., Collado-Vides, J., Gama-Castro, S., Ingraham, J., Paley, S., Paulsen, I. T., Peralta-Gil, M., and Karp, P. D. (2005) EcoCyc: a comprehensive database resource for Escherichia coli. Nucleic Acids Research 33: D334-337.