Mabbutt, Bridget - Macquarie University - Department of Chemistry and Biomolecular Sciences

研究领域

Three-dimensional molecular structure and architecture of proteins (or gene products). Structural biology (crystallography and NMR approaches) and high throughput structural genomics for functional definition. Molecular evolution of proteins as factors for microbial adaptation, pathogenicity and virulency. Protein-protein and protein-RNA interactions. Protein engineering.

近期论文

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"Recovery and evolutionary analysis of complete integron gene cassette arrays from Vibrio", Boucher, et al., BMC Evolutionary Biology 6:3 (2006). "A putative house-cleaning enzyme encoded within an integron array: 1.8 Å crystal structure defines a new MazG subtype", Robinson, et al., Molec. Microbiol. 66(3), 610-21 (2007). "Structural genomics of the bacterial mobile metagenome: An Overview", Robinson, et al., Methods Mol Biol. (2008);426:589-95 "Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: Implications for Lsm ring organisation and recruitment Naidoo", et al., J. Mol. Biol. 377, 1357-1371 (2008). "NMR assignment of prespore specific antigen - a cell surface adhesion glycoprotein from Dictyostelium discoideum." Swarbrick, et al., Biomol NMR Assign Jun 3, 1-3 (2009) "Engineered rings of yeast Lsm proteins show differential interactions with translation factors and U-Rich RNA", Sobti, M., Cubeddu, L., Haynes, P.A. and Mabbutt, B.C., Biochemistry 49 2335-45, (2010). "Crystal structure of an integron gene cassette-associated protein from vibrio cholerae identifies a cationic drug-binding module", Deshpande, et al. (2010) in prepn.