Liu, Fei - Macquarie University - Department of Chemistry and Biomolecular Sciences

个人简介

Fei did her undergraduate studies in Chemistry at John Carroll University (University Heights, Ohio), and then moved to New Haven, Connecticut for her PhD studies in Organic Chemistry at Yale. After her PhD, she moved to Boston, Massachusetts as an NIH postdoctoral fellow to work on new biosynthetic approaches in molecular medicine at the Harvard Medical School. In 2004, Fei moved from Boston to Sydney and is currently a Senior Lecturer in the Department of Chemistry and Biomolecular Sciences (CBMS) at Macquarie. The current phase of her research focuses on developing efficient synthetic methods for accessing small molecules with useful properties in chemistry and biology. Her long-term interest in chemical proteomics along with its applications in basic biological discovery and medicine is being pursued in close collaboration with the Australian Proteomics Analysis Facility (APAF).

研究领域

Catalytic and stereo-selective reactions for efficient generation of synthons or biological probes. Isozyme specific antagonist discovery by conformational selection Chemistry and biology of post-translational modifications of enzymes or proteomes

近期论文

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Liu, F.;* Koval, M.; Ranganathan, S.; Fanayan, S.; Hancock, W.; Lundberg, E.;, Beavis, R.; Lane, L.; Duek, P.; McQuade, L.; Kelleher, N.; Baker, M. J. of Prot. Res. 2016, 339-59. Systems Proteomics View of the Endogenous Human Claudin Protein Family. Kenny, R.; Liu, F.* Eur. J. Org. Chem., 2015, 5304-5319. Trifunctional Organocatalysts: Catalytic Proficiency by Cooperative Activation. Patel, A.; Hunter, L.; Bhadbhade, M. M.; Liu, F.* Eur. J. Org. Chem., 2014, 2584-2593. Conformational Regulation of Substituted Azepanes through Mono-, Di-, and Trifluorination. Patel, A.; Ball, G.; Hunter, L.; Liu, F.* Org. & Biomol. Chem., 2013, 3675-3683. Conformational regulation of substituted azepanes through selective monofluorination. Dolai, S.; Xu, M.; Liu, F.; Molloy, M.* Proteomics, 2011, 2683-2693. Quantitative chemical proteomics in small scale culture of phorbol ester stimulated basal breast cancer cells. Garnier, J. M.; Liu, F.* Org. & Biomol. Chem., 2009, 1272-1275. Trifunctional Organocatalyst Promoted Counterion Catalysis for Fast and Enantioselective aza-Morita-Baylis-Hillman Reactions at Ambient Temperature. Garnier, J-M.; Anstiss, C.; Liu, F.* Adv. Synth. & Catal., 2009, 351, 331-8. Enantioselective Trifunctional Organocatalysts for Rate-Enhanced Aza-Morita-Baylis-Hillman Reactions at Room Temperature. (Highlighted in Synfacts, 2009, 447) Stephens, B. E.; Liu, F.* J. Org. Chem. 2009, 254-263. A Regio- and Diastereoselective Intramolecular Nitrone Cycloaddition for Practical 3- and 2,3-Substituted Piperidine Synthesis from gamma-Butyrolactone. Patil, S. N.; Liu, F.* J. Org. Chem. 2008, 4476-4484. Regioselective Synthesis and Structural Studies of Substituted gamma-Hydroxybutenolides using a Tandem Baylis-Hillman/Singlet Oxygenation Reaction. Yang, M.; Liu, F.* J. Org. Chem. 2007, 8969-8971. An Ullmann Coupling of Aryl Iodides and Amines Using an Air-Stable Diazaphospholane Ligand.