Haynes, Paul - Macquarie University - Department of Chemistry and Biomolecular Sciences

研究领域

Our laboratory focuses on environmental proteomics. We work principally in plants but also in microorganisms and marine organisms such as oysters and amphipods. The unifying theme of our work is understanding how organisms respond at the molecular level to changes in their external environment. The major approach we use is applying large-scale protein identification and quantitation by mass spectrometry. Examples of recent projects include the quantitative proteomic analysis of temperature stress and drought stress in rice, heavy metal stress response in Sydney rock oysters, and environmental adaptation in New Zealand alpine plants. One area we are actively working in currently is proteogenomics, or using shotgun proteomics to improve genome annotation. We are applying this approach to grapes and several microorganisms. Our work is funded by the Australian Research Council, the NSW Government Office of Science and Medical Research, and the NSF Grape Research Coordination Network.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

K.A. Neilson, A.P. Scafaro, J.M. Chick, I.S. George, S.C. Van Sluyter, S.P. Gygi, B.J. Atwell, and P.A. Haynes. The influence of signals from chilled roots on the proteome of leaf tissues in rice seedlings. Proteomics, ISSN 1615-9853, accepted for publication, January 2013. N.M. Dheilly, D.A. Raftos, P.A. Haynes, L. Courtney Smith and S.V. Nair. Shotgun proteomics of coelomic fluid from the purple sea urchin, Strongylocentrotus purpuratus. Developmental and Comparative Immunology, ISSN: 0145-305X, Jan 23. [Epub ahead of print] 2013. Z. Jangravi, M. Alikhani, B. Arefnezhad, M. Sharifi Tabar, S. Taleahmad, R. Karamzadeh, M. Jadaliha, S.A. Mousavi , D. Ahmadi Rastegar, P. Parsamatin, H. Vakilian, S. Mirshahvaladi, M. Sabbaghian, A. Mohseni Meybodi, M. Mirzaei, M. Shahhoseini, M. Ebrahimi, A. Piryaei, A.A. Moosavi-Movahedi , P.A. Haynes, A.K. Goodchild, M.H. Nasr-Esfahani, E. Jabbari, H. Baharvand, M.A. Sedighi Gilani, H. Gourabi and G.H. Salekdeh. A Fresh Look at the Male-specific Region of the Human Y Chromosome. Journal of Proteome Research, ISSN1535-3893, Jan 4;12(1):6-22. 2013. A. Monavarfeshani, M. Mirzaei, E. Sarhadi, A. Amirkhani, M. Khayam Nekouei, P.A. Haynes, M. Mardi and G.H. Salekdeh. Shotgun Proteomic Analysis of the Mexican Lime Tree Infected with 'Candidatus Phytoplasma aurantifolia'. Journal of Proteome Research, ISSN1535-3893, Jan 7. [Epub ahead of print] 2013. K.A. Neilson, I.S. George, S. J. Emery, S. Muralidharan, M. Mirzaei and P.A. Haynes. Analysis of rice proteins using SDS-PAGE shotgun proteomics. (2013) Methods Mol. Biol. In Press, accepted for publication December 2012. K.A. Neilson, T. Keighley, D. Pascovici, B. Cooke and P.A. Haynes. Label-free quantitative shotgun proteomics using normalized spectral abundance factors. (2013) Methods Mol. Biol. In Press, accepted for publication September 2012.