个人简介
Dr Thy Truong completed her PhD (Analytical and Environmental Chemistry, 2001) at RMIT University focusing on lipid biomarkers to distinguish sources of faecal pollution in contaminated waters and sediments around popular tourist hotspots in the East Gippsland Lakes, Victoria. She also developed new optimised analytical techniques for analysing and quantifying lipid markers using multidimensional GCxGC with cryogenic trapping and GC-MS. She undertook a postdoctoral research associate position (substituting for a Senior Research Scientist as the head of the research project and the organic chemistry laboratory) at the Stroud Water Research Center in Pennsylvania investigating the use of molecular tracers for monitoring sources of contamination in streams and rivers associated with the New York City drinking water system (Safe Drinking Water Act grant funded by the U.S. EPA and the New York State Department of Environmental Conservation). In 2003 she worked as a postdoctoral fellow at RMIT University to derive a holistic approach to managing dairy processor waste streams before working as a postdoctoral fellow at the University of Melbourne investigating the environmental inorganic chemistry of phosphorus and arsenic in aquatic and terrestrial ecosystems using flow injection analysis with membrane separation and spectrophotometric or chemiluminescence detection. She then decided to gain experience in commercial FDA/NATA accredited chemical testing laboratories as an analytical chemist at Cardinal Health (pharmaceuticals), and OMIC Australia (food). Her position at CSIRO Materials Science and Engineering (April 2008 - July 2010) as an Environmental Analytical Chemist and Deputy Laboratory Manager in the Environmental Analysis Group (EAG) reignited her interests in research and method development/validation in analytical chemistry, separation science and mass spectrometry, which in turn has led her to her current appointment as RSB Mass Spectrometry Officer (February 2011 - present).
研究领域
My research, sample extraction / instrumental method development and method validation interests have always revolved around organic mass spectrometry and the associated chromatographic techniques of liquid chromatography and gas chromatography. Examples of the organic mass spectrometry research projects that I have been actively involved in have included identifying and/or quantifying (bio)molecular tracers such as:-
Current MSF projects:
Plant hormones (jasmonates, SA, ABA, auxins), pigmients, primary (cellulose and non-cellulose) and other secondary metabolites (flavonoids, saffron derivatives) to determine biosynthetic pathways and their functions, as well as associating their possible (health) benefits to humans.
Non-targeted metabolites in plants, tonsil and cancerous tissue cells, or plasma of rats or humans, and E. coli.
Other targeted biological metabolites such as short chain fatty acids, sterols and FAMES in faecal matter, plants, and fungi.
Intact proteins (direct infusion), peptides and/or tryptic peptides (including ITRAQ and MASCOT) in plants and fungi, and human or rat plasma and serum.
Dichloroacetic acid for cancer treatment.
Past employment projects:
Sterols in plants, green lip mussels and cow faeces to distinguish specific biomarkers.
Faecal steroids and bile acids to identify contaminant sources to assess water quality of the East Gippsland Lakes, Victoria.
Faecal steroids, caffeine, fragrances and PAHs to identify contaminant sources such as sewage effluent and agricultural and urban runoffs in order to assess water quality in watersheds providing source water for drinking and recreation to the people of New York City.
Pesticide residues in grains, fruits and vegetables.
Volatile organic compound (VOC) emissions from textile materials to determine indoor air quality.
Fatty acid methyl esters in facial tumours of the Tasmanian Devils (CSIRO side project).
Pesticide residues in Australian wool to support Australian wool’s environmentally friendly clean green image.
"CSI" investigation to determine presence of hydrocarbons on burnt fire uniforms.
Such collaborative research and method development/validation projects have allowed me to enhance my skills and experience in the (extensive hands-on) use and understanding of a wide range of analytical techniques, including MDGC, GCxGC, GC (FID, ECD, NPD), LC (UV-Vis, PDA, Fluorescence), MS (ion trap, quadrupole, ESI QTOF with Jetstream or Chipcube), spectroscopy (AAS, UV-Vis, FTIR), sampling and sub-sampling, and sample preparation that include various extraction and purification/clean-up methods (solvent extraction, solid phase extraction, accelerated solvent extraction, automated thermal desorption, supercritical fluid extraction, solid phase microextraction) as well as derivatisation techniques.
近期论文
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Liang Pin Jason Ng, Thy T. Truong, Charles Hocart, and Ulrike Mathesius. Quantifying Auxin Metabolites in Young Root Tissue of Medicago truncatula by Liquid Chromatography Electrospray-ionisation Quadrupole Time-of-flight (LC-ESI-QTOF) Tandem Mass Spectrometry. Bio-protocol, in press.
Qian Xu, Thy T. Truong, Jose Barrero, John V Jacobsen, Charles H. Hocart, Frank Gubler. A Role for Jasmonates in the Release of Dormancy by Cold Stratification in Wheat. Journal of Experimental Botany, Online Early Version 05/2016, doi:10.1093/jxb/erw172.
Phoebe J. Benson, Diane Purcell, Charles H. Hocart, Thy T. Truong, Gabriel O. James, Loraine Rourke, Michael A. Djordjevic, Susan I. Blackburn and G. Dean Price. Optimization of pyruvate excretion in a glycogen storage mutant of the cyanobacterium, Synechococcus PCC7942. Frontiers in Microbiology, Vol.7, April 2016.
Jason Liang Pin Ng, Samira Hassan, Thy T. Truong, Charles H. Hocart, Carole Laffont, Florian Frugier and Ulrike Mathesius. Flavonoids and Auxin Transport Inhibitors Rescue Symbiotic Nodulation in the Medicargo truncatula Cytokinin Perception Mutant cre1. The Plant Cell, Vol. 27: 1–17, August 2015.
Nadiatul A Mohd-Radzman, Steve Binos, Thy T. Truong, Nijat Imin, Michael Mariani, Michael A Djordjevic. Novel MtCEP1 peptides produced in vivo differentially regulate root development in Medicago truncatula. Journal of Experimental Botany, Online Early Version 02/2015; DOI:10.1093/jxb/erv008.
Melissa Rooke, Lucy A Coupland, Thy Truong, Anneke C Blackburn. Conference Paper: Dichloroacetate is an effective treatment for sarcoma models in vitro and in vivo. Metabolism, Diet and Disease 2014: Cancer and metabolism, Washington DC, USA; 05/2014.
Junji Miyazaki, Warwick N. Stiller, Thy T. Truong, Qian Xu, Charles H. Hocart, Lewis J. Wilson and Iain W. Wilson. Jasmonic acid is associated with resistance to twospotted spider mites in diploid cotton (Gossypium arboreum L.). Functional Plant Biology, 03/2014; 41(7):748-757.
Charles S. Buer, Farzaneh Kordbacheh, Thy T. Truong, Charles H. Hocart, Michael A. Djordjevic. Alteration of flavonoid accumulation patterns in transparent testa mutants disturbs auxin transport, gravity responses, and imparts long-term effects on root and shoot architecture. Planta, 238(1), 171 (2013).
Miki Fujita, Regina Himmelspach, Juliet Ward, Angela Whittington, Nortrud Hasenbein, Christine Liu, Thy T. Truong, Moira E. Galway, Shawn D. Mansfield, Charles H. Hocart, Geoffrey O. Wasteneys. The any1 D604N mutation in the Arabidopsis thaliana cellulose synthase 1 catalytic domain reduces cell wall crystallinity and the velocity of cellulose synthase complexes. Plant physiology, 162(1), 74 (2013).
K. Wilkinson, R. Brooks, C. Balmer, D. Halliwell, L. Palmowski, J. Issa, S. Jeyaseelan, T. Truong, H. Wilson, B. Meehan, K. Baskaran. Survey of dairy factory solid and liquid waste management practices. Final Report Project No: MP1/006 (MIS No: 07306), Closing the Loop: An holistic approach to the management of dairy processor waste streams, Dairy Industries Sustainability Consortium, June 2004.
T.T. Truong, P.J. Marriott, N.A. Porter and R. Leeming. The Application of Comprehensive Two-Dimensional Gas Chromatography to the Quantification of Overlapping Faecal Sterols. J. Chromatogr. A , 1019, 197 (2003).
T.T. Truong, C. Dow and L. Standley, Chapter 2 - Water Quality Monitoring in the Source Water Areas for New York City: An Integrated Watershed Approach - A Report on the second year of monitoring. Technical Report Contribution No. 2002014, Stroud Water Research Center, November (2002).
T.T. Truong, P.J. Marriott and N.A. Porter. Analytical study of Comprehensive and Targeted Multidimensional Gas Chromatography Incorporating Modulated Cryogenic Trapping. J. AOAC Int., 84, 323 (2001).
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