O'Neill, Helen - The Australian National University

个人简介

Helen O’Neill's research encompasses immunology and stem cell biology. She has published in viral and tumour immunology, T cell and dendritic cell development, and hematopoiesis. Helen completed a BSc Hons in Genetics at Adelaide University, then worked in medical research at Stanford University, California, before completing her PhD in 1981 in the John Curtin School of Medical Research (JCSMR; ANU). She was then appointed as a Research Fellow in JCSMR, became a Fellow in 1989, and held two overseas fellowships while on leave from JCSMR. Between 1983 and 1985 she was an NHMRC CJ Martin Fellow in Irv Weissman’s laboratory at Stanford University. Between 1987 and 1988, she was a Fellow of the International Union against Cancer in the Tumour Biology Labs at Stanford University. In 1996 she took up a research/teaching position in the School of Biochemistry and Molecular Biology at ANU, and she now Professor and Leader of the Stem Cell and Immunology Lab at the Research School of Biology.

研究领域

Hematopoiesis and microenvironments supporting stem cell differentiation Spleen as a site for extramedullary hematopoiesis Development and function of dendritic cells in normal and disease states.

近期论文

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Petvises, S., Talaulikar, D. and O’Neill, H.C. Delineation of a novel dendritic-like subset in human spleen. Cellular and Molecular Immunology, In press 1.2.15. Abbey, J.L., Karsunky, H., Serwold, T., Papathanasiou, P., Weissman, I.L. and O’Neill, H.C. (2015) Expression of TCR-Vbeta peptides by murine bone marrow cells does not identify T cell progenitors. Journal Cellular Molecular Medicine, In press 29.1.15. Ji, J., Griffiths, K., Milburn, P., Hirst, T.R. and O’Neill, H.C. EtxB alters the activation state of mature dendritic cell subsets. Journal Cellular Molecular Medicine. In press 18.3.15. O’Neill, H.C. Delineation of a novel dendritic-like subset in human spleen. Cellular and Molecular Immunology, In press 1.2.15. Petvises, S. and O’Neill, H.C. (2014) Distinct progenitor origin distinguishes a lineage of dendritic-like cells in spleen. Frontiers in Immunology, 4, Article 501, pp1-11. Doi: 10.3389/fimmu.2013.00501. Petvises, S. and O’Neill, H.C. (2014) Characterisation of dendritic cells arising from progenitors endogenous to murine spleen. Plos One 9(2): e88311. Doi:10.1371/journal.pone.0088311. O’Neill, H.C., Griffiths, K., Periasamy, P., Hinton, R.A., Petvises, S., Hey, Y.Y. and Tan, J. (2014) Splenic stroma maintains hematopoietic progenitors and supports longterm hematopoiesis. Current Stem Cells Research and Therapy 9(4), 354-363. Griffiths, K., Tan, J.K.H. and O’Neill, H.C. (2014) Characterisation of the effect of LPS on DC subset discrimination in spleen. Journal of Cellular and Molecular Medicine 18(9), 1908-1912. Periasamy P, O'Neill HC. Stroma-dependent development of two dendritic-like cell types with distinct antigen presenting capability. Exp Hematol. 2013;41(3):281-92. (PDF, 1391KB) Periasamy, P. and O’Neill, H.C. (2013) In vitro hematopoiesis reveals a novel dendritic-like cell also present in murine spleen. Current Stem Cell Research and Therapy, 8(5), 365-369. Invited review. Periasamy P, Petvises, O'Neill HC. Development of two distinct dendritic-like APCs in the context of splenic stroma. Front Immunol. 2013; doi: 10.3389/fimmu.2013.00073. (PDF, 2013KB) Periasamy P, Tan JK, O'Neill HC. Novel splenic antigen-presenting cells derive from a Lin(-) c-kit(lo) progenitor. J Leukoc Biol. 2013;93(1):63-9. (PDF,1230 KB) O'Neill HC, Griffiths KL, Periasamy P, et al. Spleen as a site for hematopoiesis of a distinct antigen presenting cell type. Stem Cells Int. 2011;doi: 10.4061/2011/954275. (PDF, 3122KB) Tan JK, Periasamy P, O'Neill HC. Delineation of precursors in murine spleen that develop in contact with splenic endothelium to give novel dendritic-like cells. Blood. 2010;115:3678-85. (PDF, 1615KB) Tan JKH, Quah BJC, Griffiths KL, Periasamy P, Hey,Y-Y, O’Neill HC. Identification of a novel antigen cross-presenting cell in spleen: a counterpart to cells produced in long-term culture. J Cell Mol Med. 2011;15(5):1189-99. (PDF, 892KB) Tan JKH, O’Neill C. Investigation of spleen as a niche for hematopoiesis. Transplantation. 2010;89(2):140-5. (PDF, 985KB) Periasamy P, Tan JK, Griffiths KL, et al. Splenic stromal niches support hematopoiesis of dendritic-like cells from precursors in bone marrow and spleen. Exp Hematol. 2009;37:1060-71. (PDF, 1024KB) Tan JK, O'Neill HC. Concise review: Dendritic cell development in the context of the spleen microenvironment. Stem Cells. 2007;25:2139-45. (PDF, 2356KB) Despars G, O'Neill HC. Splenic endothelial cell lines support development of dendritic cells from bone marrow. Stem Cells. 2006;24:1496-504.(PDF, 533KB) O'Neill HC, Wilson HL, Quah B, et al. Dendritic cell development in long-term spleen stromal cultures. Stem Cells. 2004;22:475-86. (PDF, 209KB) Quah B, Ni K, O’Neill HC. In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity. Int Immunol. 2004;16: 567-77. (PDF, 436KB)