研究领域

Synthesis/Biological

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages. • Diversity-Oriented Synthesis • Synthetic Methodology: Medium Ring Synthesis and Natural Product Synthesis • Quorum Sensing • New Antibiotic Discovery • Modulation of Protein-Protein Interactions • Molecular Therapeutics: Chemistry-Driven Drug Discovery We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha TH Sum, TJ Sum, JE Stokes, WRJD Galloway, DR Spring – Tetrahedron (2015) (DOI: 10.1016/j.tet.2015.02.017) Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction E Alza, L Laraia, BM Ibbeson, S Collins, WRJD Galloway, JE Stokes, AR Venkitaraman, DR Spring – Chem. Sci. (2015) 6, 390 (DOI: 10.1039/C4SC02547D) Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis. MS Frei, MK Bilyard, TA Alanine, WR Galloway, JE Stokes, DR Spring – Bioorganic & medicinal chemistry (2014) (DOI: 10.1016/j.bmc.2014.11.037) Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation Z Walsh, ER Janeček, JT Hodgkinson, J Sedlmair, A Koutsioubas, DR Spring, M Welch, CJ Hirschmugl, C Toprakcioglu, JR Nitschke, M Jones, OA Scherman – Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 17743 (DOI: 10.1073/pnas.1406037111) Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides. YH Lau, P de Andrade, GJ McKenzie, AR Venkitaraman, DR Spring – Chembiochem (2014) 15, 2680 (DOI: 10.1002/cbic.201402374) Diversity-Oriented Synthesis of Drug-Like Macrocyclic Scaffolds Using an Orthogonal Organo- and Metal Catalysis Strategy A Grossmann, S Bartlett, M Janecek, JT Hodgkinson, DR Spring – Angew Chem Int Ed Engl (2014) 53, 13093 (DOI: 10.1002/anie.201406865) Peptide stapling techniques based on different macrocyclisation chemistries. YH Lau, P de Andrade, Y Wu, DR Spring – Chemical Society reviews (2015) 44, 91 (DOI: 10.1039/C4CS00246F) Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae SW Wachira, S Omar, JW Jacob, M Wahome, HT Alborn, DR Spring, DK Masiga, B Torto – Parasites & vectors (2014) 7, 312 (DOI: 10.1186/1756-3305-7-312) Arene C-H functionalisation using a removable/modifiable or a traceless directing group strategy. F Zhang, DR Spring – Chemical Society reviews (2014) 43, 6906 (DOI: 10.1039/c4cs00137k) The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations YS Tan, DR Spring, C Abell, C Verma – J Chem Inf Model (2014) 54, 1821 (DOI: 10.1021/ci500215x) Investigating peptide sequence variations for ‘double-click’ stapled p53 peptides YH Lau, P de Andrade, N Sköld, GJ McKenzie, AR Venkitaraman, C Verma, DP Lane, DR Spring – Org Biomol Chem (2014) 12, 4074 (DOI: 10.1039/c4ob00742e) Small molecule modulation of quorum sensing pathways DR Spring – ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2014) 247 Diversity-oriented synthesis as a tool for identifying new modulators of mitosis BM Ibbeson, L Laraia, E Alza, CJ O' Connor, YS Tan, HM Davies, G McKenzie, AR Venkitaraman, DR Spring – Nature Communications (2014) 5, 3155 (DOI: 10.1038/ncomms4155) Concise synthesis of substituted quinolizin-4-ones by ring-closing metathesis TA Alanine, WRJD Galloway, TM McGuire, DR Spring – European Journal of Organic Chemistry (2014) 2014, 5767 (DOI: 10.1002/ejoc.201402648) Concise synthesis of substituted quinolizin-4-ones by ring-closing metathesis TA Alanine, WRJD Galloway, TM Mcguire, DR Spring – European Journal of Organic Chemistry (2014) 2014, 5767 (DOI: 10.1002/ejoc.201402648) Functionalised staple linkages for modulating the cellular activity of stapled peptides YH Lau, P De Andrade, S-T Quah, M Rossmann, L Laraia, N Sköld, TJ Sum, PJE Rowling, TL Joseph, C Verma, M Hyvönen, LS Itzhaki, AR Venkitaraman, CJ Brown, DP Lane, DR Spring – Chemical Science (2014) 5, 1804 (DOI: 10.1039/c4sc00045e) High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics L Laraia, J Stokes, A Emery, GJ McKenzie, AR Venkitaraman, DR Spring – ACS Med Chem Lett (2014) 5, 598 (DOI: 10.1021/ml5000564) Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2 KL Irvine, M Gangloff, CM Walsh, DR Spring, NJ Gay, CE Bryant – PLoS One (2014) 9, e98776 (DOI: 10.1371/journal.pone.0098776) Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe T Liu, X Liu, DR Spring, X Qian, J Cui, Z Xu – Scientific reports (2014) 4, 5418 (DOI: 10.1038/srep05418) How diverse are diversity assessment methods? A comparative analysis and benchmarking of molecular descriptor space A Koutsoukas, S Paricharak, WR Galloway, DR Spring, AP Ijzerman, RC Glen, D Marcus, A Bender – J Chem Inf Model (2014) 54, 230 (DOI: 10.1021/ci400469u)