Martin, Rowena - The Australian National University

个人简介

Rowena Martin carried out her PhD in the School of Biochemistry and Molecular Biology ANU, taking a multidisciplinary approach to understanding membrane transport in the malaria parasite. Her work spans the fields of cell physiology, biochemistry, bioinformatics, and molecular biology. In 2005 she took up a postdoc position at the ANU to pursue work she had initiated during her PhD on drug resistance in the malaria parasite and was awarded the 2007 Early Career Researcher Award of the ARC/NHMRC Research Network for Parasitology for this research. She has received a NHMRC Early Career Biomedical Fellowship (undertaken 2009-2012 at the University of Melbourne's School of Botany and ANU's Research School of Biology) and a NHMRC R.D. Wright Biomedical Fellowship (2013-16 at ANU's Research School of Biology). In 2010 she was awarded the inaugural Australian Museum Eureka Prize for Early Career Research, a L’Oréal Australia For Women In Science Fellowship [YouTube], and an ACT Young Tall Poppy Science Award.

研究领域

The malaria parasite is a single-celled microorganism which invades the red blood cells of its host. Malaria remains a major infectious disease in many parts of the world, causing over 200 million clinical cases and around 500,000 deaths per year. Moreover, malaria imposes horrendous economic burdens upon afflicted countries. An effective vaccine remains elusive and reliance on chemotherapy is under serious threat with the emergence of parasites that are resistant to most, if not all, of the antimalarial drugs available. We use a combination of biochemistry, chemistry, molecular biology, and bioinformatic techniques to study: Membrane transport proteins of the malaria parasite, with an emphasis on those involved in drug resistance Mechanisms of drug resistance and drug action in the malaria parasite Design of novel antimalarial drugs and antimalarial strategies.

近期论文

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Richards SN1, Nash MN1, Baker ES, MW Webster, Lehane AM, Shafik SH and Martin RE (2016). Molecular mechanisms for drug hypersensitivity induced by the malaria parasite's chloroquine resistance transporter. PLOS Pathogens, 12: e1005725. [1: Joint first authors] Open access Veiga MI1, Dhingra SK1, Henrich PP, Straimer J, Gnadig N, Uhlemann A, Martin RE, Lehane AM and Fidock DA (2016). Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies. Nature Communications, 7: 11553. [1: Joint first authors] Open access van Schalkwyk DA1, Nash MN1, Shafik SH1, Summers RL, Lehane AM, Smith PJ and Martin RE (2015). Verapamil-sensitive transport of quinacrine and methylene blue via the Plasmodium falciparum chloroquine resistance transporter reduces the parasite's susceptibility to these tricyclic drugs.Journal of Infectious Diseases, 213: 800-810. [1: Joint first authors] Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Llinás M, Ferguson DJP, Martin RE, Fidock DA, Cooper RA and Krishna S (2015). Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities. Scientific Reports, 5: 14552. Open access Marchetti RV, Lehane AM, Shafik SH, Winterberg M, Martin RE and Kirk K (2015). A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum. Nature Communications, 6: Article 6721. Open access Kirk K and Martin RE (2015). Membrane transport in the malaria parasite, in the Encyclopedia of Malaria (P Kremsner & M Hommel chief eds), Springer, pp 1-11. Bellanca S, Summers RL, Meyrath M, Dave A, Nash MN, Dittmer M, Sanchez CP, Stein WD,Martin RE1 and Lanzer M1 (2014). Multiple drugs compete for transport via the P. falciparum chloroquine resistance transporter at distinct but interdependent sites. Journal of Biological Chemistry, 289: 36336-51. [1: Joint senior authors] Open access Teng R1, Lehane AM1, Winterberg M, Shafik SH, Summers RL, Martin RE, van Schalkwyk DA, Junankar PR, Kirk K (2014). 1H NMR metabolite profiles of different strains of Plasmodium falciparum. Bioscience Reports, 34: art:e00150. [1: Joint first authors] Open access Summers RL1, Dave A1, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M2 and Martin RE2 (2014). Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite’s chloroquine resistance transporter. Proceedings of the National Academy of Sciences USA, 111: E1759-67. [1, 2: Equal contributions] Open access Deane KJ1, Summers RL1, Lehane AM, Martin RE2 and Barrow RA2 (2014). Chlorpheniramine analogues reverse chloroquine resistance in Plasmodium falciparum by inhibiting PfCRT. ACS Medicinal Chemistry Letters, 5: 576-81 [1, 2: Equal contributions] Hrycyna CA1, Summers RL1, Lehane AM1, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J2 and Martin RE2 (2013). Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum. ACS Chemical Biology, 9:722-30 [1, 2: Equal contributions] Open access Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G and Butini S (2012). Mimicking the intramolecular hydrogen Bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents. Journal of Medicinal Chemistry, 55: 10387-10404. Gemma S, Camodeca C, Sanna Coccone S, Joshi BP, Bernetti M, Moretti V, Brogi S, Bonache MC, Savini L, Taramelli D, Basilico N, Parapini S, Rottmann M, Brun R, Lamponi S, Caccia S, Guiso G, Summers RL, Martin RE, Saponara S, Gorelli B, Novellino E, Campiani G and Butini S (2012). Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivostudies, and preliminary toxicity profiling. Journal of Medicinal Chemistry, 55: 6948-67. Martin RE, Butterworth A, Gardiner D, Kirk K, McCarthy JS and Skinner-Adams TS (2012). Saquinavir inhibits the malaria parasite's chloroquine resistance transporter. Antimicrobial Agents and Chemotherapy, 56: 2283-9. Open access Summers, RL, Nash MN and Martin RE (2012). Know your enemy: Understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics. Cellular and Molecular Life Sciences, 69, 1967-95. Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE and Egan TJ (2011). Quinoline antimalarials containing a dibemethin group are active against chloroquine-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine resistance transporter. Journal of Medicinal Chemistry, 54, 6956-68. Zishiri VK, Hunter R, Smith PJ, Taylor D, Summers RL, Kirk K, Martin RE and Egan TJ (2011). A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT. European Journal of Medicinal Chemistry, 46: 1729-42. Cobbold SA, Martin RE and Kirk K (2011). Methionine transport in the malaria parasite, Plasmodium falciparum. International Journal of Parasitology, 41: 125-135. Summers, RL and Martin RE (2010). Functional characteristics of the malaria parasite’s ‘chloroquine resistance transporter’: implications for chemotherapy. Virulence, 1, 304-08. Open access Martin RE, Ginsburg H and Kirk K (2009). Membrane transport proteins of the malaria parasite. Molecular Microbiology, 74: 519-528.