个人简介
学习工作经历
2004 – 2008 南京大学匡亚明学院强化部理科强化班，本科
2008 – 2013 南京大学化学化工学院，硕士和博士研究生，有机化学，导师：潘毅
2013 – 2016 南京大学化学与生物医学科学研究所研究助理和秘书
2016 – 2020 以色列理工学院，博士后，化学生物学，导师：Aaron Ciechanover 和 Ashraf Brik 2020 – 南京农业大学理学院，教授，博士生导师
近期论文
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1. Muna Msallam, Hao Sun (#共同第一作者), Roman Meledin, Pauline Franz and Ashraf Brik, “Examining the role of phosphorylation of p19INK4d on Ser66 and Ser76 on its Stability and Ubiquitination using Chemical Protein Synthesis”, Chemical Science, 2020, 11, 5526-5531. (Impact factor: 9.6) 2. Hao Sun, Ashraf Brik. “The journey for the total chemical Synthesis of a 53 kDa Protein”, Acc. Chem. Res., 2019, 52, 3361-3371. （这篇文章被选作期刊封面）(Impact factor: 21.7) 3. Hao Sun, Sachitanand M. Mali, Sumeet K. Singh, Roman Meledin, Ashraf Brik, Yong
Tae Kwon, Yelena Kravtsova-Ivantsiv, Beatrice Bercovich, Aaron Ciechanover. “Diverse Fate of Ubiquitin Chain Moieties: The Proximal is Degraded with the Target, and the Distal Protects from Removal and Recycles”, PNAS, 2019, 116, 7805-7812. (PNAS杂志另外刊登了这个成果的评论文章 “Synthetic ubiquitinated proteins meet the proteasome: Distinct roles of ubiquitin in a chain，PNAS, 2019, 116, 7614-7616.”) (Impact factor: 9.6) 4. Shay Laps, Hao Sun (#共同第一作者), Guy Kamnesky and Ashraf Brik, “Palladium Mediated Direct Disulfide Bond Formation in Proteins Containing S-Acetamidomethyl-Cysteine under Aqueous Conditions”, Angew. Chem. Int. Ed., 2019, 58, 5729-5733. (Impact factor: 12.3) 5. Hao Sun, Roman Meledin, Sachitanand M. Mali, Ashraf Brik, “Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases”, Chemical Science, 2018, 9, 1661-1665. (Impact factor: 9.6) 6. Yichao Huang#, Mickal Nawatha#, Ido Livneh, Joseph M. Rogers, Hao Sun, Sumeet K. Singh, Aaron Ciechanover, Ashraf Brik* and Hiroaki Suga, “Affinity Maturation of Macrocyclic Peptide Modulators of Lys48‐linked Diubiquitin by a Twofold Strategy”, Chemistry-A European Journal, 2020, 31, 889-894. (Impact factor: 5.2) 7. Emad Eid#, Gabor Boross#, Hao Sun, Muna Msallam, Sumeet Singh and Ashraf Brik, “Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions”, Bioconjugate Chemistry, 2020, online. (Impact factor: 4.4) 8. Mickal Nawatha, Joseph Rogers, Steven M. Bonn, Ido Livneh, Betsegaw Lemma, Sachitanand M. Mali, Ganga Babu, Hao Sun, Beatrice Bercovich, Aaron Ciechanover, David Fushman, Hiroaki Suga, Ashraf Brik, “Discovery of de novo macrocyclic peptide modulators of Lys48-linked ubiquitin chains aided by total protein synthesis”, Nature Chemisitry, 2019, 11, 644, 652. (Impact factor: 23.2) 9. Melesse Nune, Michael T Morgan, Zaily Connell, Laura McCullough, Muhammad Jbara, Hao Sun, Ashraf Brik, Tim Formosa, Cynthia Wolberger, FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics, eLife, 2019, 8: e40988. (Impact factor: 7.6) 10. Muhammad Jbara, Hao Sun, Guy Kamnesky, Ashraf Brik, “Chemical chromatin ubiquitylation”, Current Opinion in Chemical Biology, 2018, 45, 18-26. (Impact factor: 8.5)
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