研究领域

Synthesis/Materials

We are interested in molecular recognition, aiming to uncover and exploit the rules governing non-covalent interactions. Hydrophobic, π–π, donor–acceptor, metal– ligand and hydrogen bonding interactions are used to create new supramolecular systems that expand our understanding of molecular behaviour and may have useful recognition, catalytic or photophysical properties. In particular in the past few years we have developed the concept of dynamic combinatorial chemistry as a new approach for discovering entirely unexpected structures and assemblies. Over the years our building blocks have included peptides, metalloporphyrins, steroids and simple aromatics, and our products have included macrocycles, rotaxanes, catenanes, molecular knots and supramolecular nanotubes. Some examples are shown below.

近期论文

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Direct Observation of Intermediates in a Thermodynamically Controlled Solid-State Dynamic Covalent Reaction AM Belenguer, GI Lampronti, DJ Wales, JK Sanders – Journal of the American Chemical Society (2014) 136, 16156 (DOI: 10.1021/ja500707z) Homochiral and meso figure eight knots and a Solomon link. N Ponnuswamy, FB Cougnon, GD Pantoş, JK Sanders – Journal of the American Chemical Society (2014) 136, 8243 (DOI: 10.1021/ja4125884) Disulfide exchange: exposing supramolecular reactivity through dynamic covalent chemistry SP Black, JK Sanders, AR Stefankiewicz – Chemical Society reviews (2014) 43, 1861 (DOI: 10.1039/c3cs60326a) Editorial: how can change be achieved?- energy saving in cambridge. JK Sanders – Angew Chem Int Ed Engl (2013) 52, 10914 (DOI: 10.1002/anie.201306176) Generation of a Dynamic System of Three-Dimensional Tetrahedral Polycatenanes SP Black, AR Stefankiewicz, MM Smulders, D Sattler, CA Schalley, JR Nitschke, JK Sanders – Angew Chem Int Ed Engl (2013) 52, 5749 (DOI: 10.1002/anie.201209708) Diverse topologies in dynamic combinatorial libraries from tri- and mono-thiols in water: sensitivity to weak supramolecular interactions. AR Stefankiewicz, JK Sanders – Chemical communications (Cambridge, England) (2013) 49, 5820 (DOI: 10.1039/c3cc41158c) Evolution of Dynamic Combinatorial Chemistry FB Cougnon, JK Sanders – Accounts of Chemical Research (2012) 45, 2211 (DOI: 10.1021/ar200240m) Structural parameters governing the dynamic combinatorial synthesis of catenanes in water. FB Cougnon, N Ponnuswamy, NA Jenkins, GD Pantoş, JK Sanders – Journal of the American Chemical Society (2012) 134, 19129 (DOI: 10.1021/ja3075727) Discovery of an organic trefoil knot. N Ponnuswamy, FB Cougnon, JM Clough, GD Pantoş, JK Sanders – Science (2012) 338, 783 (DOI: 10.1126/science.1227032) Self-assembly of topologically complex architectures SP Black, JKM Sanders, JR Nitschke, AR Stefankiewicz, MMJ Smulders – ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2012) 244 Template-directed dynamic combinatorial chemistry AR Stefankiewicz, M Sambrook, JKM Sanders – ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2012) 244 Metal induced folding: synthesis and conformational analysis of the lanthanide complexes of two 44-membered hydrazone macrocycles JM Klein, JK Clegg, V Saggiomo, L Reck, U Lüning, JK Sanders – Dalton transactions (Cambridge, England : 2003) (2012) 41, 3780 (DOI: 10.1039/c2dt11861k) Interactions Between Amino Acid-Tagged Naphthalenediimide and Single Walled Carbon Nanotubes for the Design and Construction of New Bioimaging Probes ZY Hu, GD Pantos, N Kuganathan, RL Arrowsmith, RMJ Jacobs, G Kociok-Kohn, J O'Byrne, K Jurkschat, P Burgos, RM Tyrrell, SW Botchway, JKM Sanders, SI Pascu – Advanced Functional Materials (2012) 22, 503 (DOI: 10.1002/adfm.201101932) Dynamic combinatorial libraries for the recognition of heavy metal ions. JM Klein, V Saggiomo, L Reck, U Lüning, JK Sanders – Org Biomol Chem (2012) 10, 60 (DOI: 10.1039/c1ob05976a) Template-directed synthesis of multi-component organic cages in water AR Stefankiewicz, MR Sambrook, JKM Sanders – Chemical Science (2012) 3, 2326 (DOI: 10.1039/c2sc20347b) Templated dynamic synthesis of a [3]catenane. FB Cougnon, NA Jenkins, GD Pantoş, JK Sanders – Angew Chem Int Ed Engl (2012) 51, 1443 (DOI: 10.1002/anie.201106885) Thermodynamics of supramolecular naphthalenediimide nanotube formation: The influence of solvents, side chains, and guest templates N Ponnuswamy, GD Pantoş, MM Smulders, JK Sanders – Journal of the American Chemical Society (2012) 134, 566 (DOI: 10.1021/ja2088647) Supramolecular naphthalenediimide nanotubes. N Ponnuswamy, AR Stefankiewicz, JK Sanders, GD Pantoş – Top Curr Chem (2012) 322, 217 (DOI: 10.1007/128_2011_305) Proton-Driven Switching Between Receptors for C-60 and C-70 AR Stefankiewicz, E Tamanini, GD Pantoş, JK Sanders – Angew Chem Int Ed Engl (2011) 50, 5724 (DOI: 10.1002/anie.201100806) Discovery of Linear Receptors for Multiple Dihydrogen Phosphate Ions Using Dynamic Combinatorial Chemistry SR Beeren, JK Sanders – Journal of the American Chemical Society (2011) 133, 3804 (DOI: 10.1021/ja200130h)