Wang, Jin - Baylor College of Medicine - Department of Pharmacology and Chemical Biology

个人简介

Education BS from Peking University 07/2003 - Beijing, China Chemistry PhD from The Ohio State University 12/2007 - Columbus, Ohio United States Organic Chemistry Postdoctoral Training at University of North Carolina at Chapel Hill 05/2011 - Chapel Hill, North Carolina United States Drug Delivery and Nanomedicine Honors & Awards Michael E. DeBakey, M.D., Professorship in Pharmacology Baylor College of Medicine (06/2021) Teaching Award - Outstanding Lecturer Baylor College of Medicine Graduate School (12/2020) Teaching Award - Chemical Biology as the Best Course in the CPSB Program Baylor College of Medicine Graduate School (12/2020) Distinguished Faculty Award Chinese American Chemistry & Chemical Biology Professors Association (CAPA) (12/2020) CPRIT Scholar in Cancer Research Cancer Prevention and Research Institute of Texas (CPRIT) (07/2011)

研究领域

Chemical Biology Sensors and Probes Small Molecule Drug Discovery Proteolysis-Targeting Chimeras (PROTACs), Targeted Protein Degradation (TPD) Antibody Drug Conjugates (ADCs) Proteomics and Metabolomics Cancer Immunotherapies Auto-inflammatory and auto-immune diseases Neurodegenerative diseases, such as Alzheimer's disease (AD) Metabolic diseases, such as obesity

近期论文

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Lin H, Wang L, Jiang X, Wang J. Glutathione dynamics in subcellular compartments and implications for drug development. Curr Opin Chem Biol. 2024 Aug;81:102505. doi: 10.1016/j.cbpa.2024.102505. Epub 2024 Jul 24. Review. PubMed PMID: 39053236. Wang L, Lin H, Yang B, Jiang X, Chen J, Roy Chowdhury S, Cheng N, Nakata PA, Lonard DM, Wang MC, Wang J. Development of a Novel Amplifiable System to Quantify Hydrogen Peroxide in Living Cells. J Am Chem Soc. 2024 Jul 30;. doi: 10.1021/jacs.4c05366. [Epub ahead of print] PubMed PMID: 39079063. Yu X, Lin H, Li F, Wang J, Lu D. Development of Biochemical and Cellular Probes to Study RIPK1 Target Engagement. ACS Med Chem Lett. 2024 Jun 13;15(6):906-916. doi: 10.1021/acsmedchemlett.4c00104. eCollection 2024 Jun 13. PubMed PMID: 38894934; PubMed Central PMCID: PMC11181498. Qin X, Wang Y, Ye Q, Hakenjos JM, Wang J, Teng M, Guo L, Tan Z, Young DW, MacKenzie KR, Li F. CYP3A Mediates an Unusual C(sp(2))-C(sp(3)) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism. Angew Chem Int Ed Engl. 2024 Jun 3;63(23):e202405197. doi: 10.1002/anie.202405197. Epub 2024 Apr 29. PubMed PMID: 38574245; PubMed Central PMCID: PMC11126355. Lin H, Riching K, Lai M, Lu D, Cheng R, Qi X, Wang J. Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools Monitoring Targeted Protein Degradation. [preprint]. 2024 May. doi: 10.1101/2024.05.14.594249. Bijou I, Liu Y, Lu D, Chen J, Sloan S, Alinari L, Lonard DM, O'Malley BW, Wang M, Wang J. Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma. PLoS One. 2024;19(4):e0289902. doi: 10.1371/journal.pone.0289902. eCollection 2024. PubMed PMID: 38683834; PubMed Central PMCID: PMC11057735. Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, Song X, MacKenzie KR, Yu X, Yang B, Roy Chowdhury S, Korp JD, O'Malley BW, Lonard DM, Wang J. Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 Apr 11;67(7):5333-5350. doi: 10.1021/acs.jmedchem.3c01596. Epub 2024 Mar 29. PubMed PMID: 38551814; PubMed Central PMCID: PMC11105966. Wang J, Lu D, Yu X, Qi X, Lin H, Holloman B, Jin F, Xu L, Ding L, Peng W, Wang M, Chen X. Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity. [preprint]. 2024 April. doi: 10.21203/rs.3.rs-4156736/v1. Yu X, Lu D, Qi X, Lin H, Holloman BL, Jin F, Xu L, Ding L, Peng W, Wang MC, Chen X, Wang J. Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity. bioRxiv. 2024 Mar 29;. doi: 10.1101/2024.03.25.586133. PubMed PMID: 38590362; PubMed Central PMCID: PMC11000689. Sun Z, Lin H, Hu L, Neetu N, Sankaran B, Wang J, Prasad BVV, Palzkill T. Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J Biol Chem. 2024 Jan;300(1):105493. doi: 10.1016/j.jbc.2023.105493. Epub 2023 Nov 23. PubMed PMID: 38000656; PubMed Central PMCID: PMC10716778. Lv X, Lu X, Cao J, Luo Q, Ding Y, Peng F, Pataer A, Lu D, Han D, Malmberg E, Chan DW, Wang X, Savage SR, Mao S, Yu J, Peng F, Yan L, Meng H, Maneix L, Han Y, Chen Y, Yao W, Chang EC, Catic A, Lin X, Miles G, Huang P, Sun Z, Burt B, Wang H, Wang J, Yao QC, Zhang B, Roth JA, O'Malley BW, Ellis MJ, Rimawi MF, Ying H, Chen X. Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors. Science. 2023 Sep 8;381(6662):eabn4180. doi: 10.1126/science.abn4180. Epub 2023 Sep 8. PubMed PMID: 37676964; PubMed Central PMCID: PMC10720158. Comerota MM, Gedam M, Xiong W, Jin F, Deng L, Wang MC, Wang J, Zheng H. Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer's disease. Mol Neurodegener. 2023 Aug 15;18(1):56. doi: 10.1186/s13024-023-00648-x. PubMed PMID: 37580742; PubMed Central PMCID: PMC10426131. Qi X, Chen J, Jiang X, Lu D, Yu X, Lin H, Monroy E, Wang M, Wang J. Quantification of glutathione with high throughput live-cell imaging. [preprint]. 2023 July. doi: 10.1101/2023.07.11.548586. Yu W, Chen Y, Putluri N, Osman A, Coarfa C, Putluri V, Kamal AHM, Asmussen JK, Katsonis P, Myers JN, Lai SY, Lu W, Stephan CC, Powell RT, Johnson FM, Skinner HD, Kazi J, Ahmed KM, Hu L, Threet A, Meyer MD, Bankson JA, Wang T, Davis J, Parker KR, Harris MA, Baek ML, Echeverria GV, Qi X, Wang J, Frederick AI, Walsh AJ, Lichtarge O, Frederick MJ, Sandulache VC. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer. 2023 Jun;128(11):2013-2024. doi: 10.1038/s41416-023-02253-7. Epub 2023 Apr 3. PubMed PMID: 37012319; PubMed Central PMCID: PMC10205814. Paudel RR, Lu D, Roy Chowdhury S, Monroy EY, Wang J. Targeted Protein Degradation via Lysosomes. Biochemistry. 2023 Feb 7;62(3):564-579. doi: 10.1021/acs.biochem.2c00310. Epub 2022 Sep 21. Review. PubMed PMID: 36130224; PubMed Central PMCID: PMC10245383. Comerota M, Gedam M, Xiong W, Jin F, Deng L, Wang M, Wang J, Zheng H. Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates Ab pathology in a mouse model of Alzheimer’s disease. [preprint]. 2023 January. doi: 10.21203/rs.3.rs-2484513/v1. Yu X, Wang J. Quantitative measurement of PROTAC intracellular accumulation. Methods Enzymol. 2023;681:189-214. doi: 10.1016/bs.mie.2022.11.001. Epub 2022 Dec 19. PubMed PMID: 36764757; PubMed Central PMCID: PMC11102804. Yu X, Wang J. Quantitative measurement of PROTAC intracellular accumulation. In: Methods in Enzymology [Internet] Elsevier; 2023. 189-214p. Available from: https://linkinghub.elsevier.com/retrieve/pii/S007668792200444X. Lu D, Yu X, Lin H, Cheng R, Monroy EY, Qi X, Wang MC, Wang J. Applications of covalent chemistry in targeted protein degradation. Chem Soc Rev. 2022 Nov 14;51(22):9243-9261. doi: 10.1039/d2cs00362g. Review. PubMed PMID: 36285735; PubMed Central PMCID: PMC9669245. Lu S, Hu L, Lin H, Judge A, Rivera P, Palaniappan M, Sankaran B, Wang J, Prasad BVV, Palzkill T. An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes. Nat Commun. 2022 Nov 7;13(1):6726. doi: 10.1038/s41467-022-34564-3. PubMed PMID: 36344533; PubMed Central PMCID: PMC9640584. Han SJ, Sung N, Wang J, O'Malley BW, Lonard DM. Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment. Breast Cancer Res. 2022 Oct 31;24(1):73. doi: 10.1186/s13058-022-01568-2. PubMed PMID: 36316775; PubMed Central PMCID: PMC9620627. Savini M, Folick A, Lee YT, Jin F, Cuevas A, Tillman MC, Duffy JD, Zhao Q, Neve IA, Hu PW, Yu Y, Zhang Q, Ye Y, Mair WB, Wang J, Han L, Ortlund EA, Wang MC. Lysosome lipid signalling from the periphery to neurons regulates longevity. Nat Cell Biol. 2022 Jun;24(6):906-916. doi: 10.1038/s41556-022-00926-8. Epub 2022 Jun 9. PubMed PMID: 35681008; PubMed Central PMCID: PMC9203275. Yu X, Guo WH, Lin H, Cheng R, Monroy EY, Jin F, Ding L, Lu D, Qi X, Wang MC, Wang J. Discovery of a potent BTK and IKZF1/3 triple degrader through reversible covalent BTK PROTAC development. Curr Res Chem Biol. 2022;2. doi: 10.1016/j.crchbi.2022.100029. Epub 2022 May 17. PubMed PMID: 36712232; PubMed Central PMCID: PMC9879287. Wang L, Jin F, Jiang X, Chen J, Wang MC, Wang J. Fluorescent Probes and Mass Spectrometry-Based Methods to Quantify Thiols in Biological Systems. Antioxid Redox Signal. 2022 Feb;36(4-6):354-365. doi: 10.1089/ars.2021.0204. Review. PubMed PMID: 34521263; PubMed Central PMCID: PMC8865626. Qin L, Chen J, Lu D, Jain P, Yu Y, Cardenas D, Peng X, Yu X, Xu J, Wang J, O'Malley BW, Lonard DM. Development of improved SRC-3 inhibitors as breast cancer therapeutic agents. Endocr Relat Cancer. 2021 Aug 13;28(10):657-670. doi: 10.1530/ERC-20-0402. PubMed PMID: 34310341; PubMed Central PMCID: PMC8404148. Du S, Jin F, Maneix L, Gedam M, Xu Y, Catic A, Wang MC, Zheng H. FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology. Aging Cell. 2021 Aug;20(8):e13432. doi: 10.1111/acel.13432. Epub 2021 Jul 11. PubMed PMID: 34247441; PubMed Central PMCID: PMC8373366. Cheng N, Mo Q, Donelson J, Wang L, Breton G, Rodney GG, Wang J, Hirschi KD, Wehrens XHT, Nakata PA. Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. Int J Biol Sci. 2021;17(11):2871-2883. doi: 10.7150/ijbs.60263. eCollection 2021. PubMed PMID: 34345213; PubMed Central PMCID: PMC8326124. Xu Y, Propson NE, Du S, Xiong W, Zheng H. Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27). doi: 10.1073/pnas.2023418118. PubMed PMID: 34187889; PubMed Central PMCID: PMC8271658. Mutlu AS, Duffy J, Wang MC. Lipid metabolism and lipid signals in aging and longevity. Dev Cell. 2021 May 17;56(10):1394-1407. doi: 10.1016/j.devcel.2021.03.034. Epub 2021 Apr 22. Review. PubMed PMID: 33891896; PubMed Central PMCID: PMC8173711. Rhoades D, Rheingold AL, O'Malley BW, Wang J. Expedient Total Syntheses of Pladienolide-Derived Spliceosome Modulators. J Am Chem Soc. 2021 Apr 7;143(13):4915-4920. doi: 10.1021/jacs.1c01135. Epub 2021 Mar 23. PubMed PMID: 33755462. Foster J, Cheng N, Paris V, Wang L, Wang J, Wang X, Nakata PA. An Arabidopsis Oxalyl-CoA Decarboxylase, AtOXC, Is Important for Oxalate Catabolism in Plants. Int J Mol Sci. 2021 Mar 23;22(6). doi: 10.3390/ijms22063266. PubMed PMID: 33806862; PubMed Central PMCID: PMC8004701. Liu J, Xie Y, Guo J, Li X, Wang J, Jiang H, Peng Z, Wang J, Wang S, Li Q, Ye L, Zhong Y, Zhang Q, Liu X, Lonard DM, Wang J, O'Malley BW, Liu Z. Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun. 2021 Feb 15;12(1):1022. doi: 10.1038/s41467-021-21386-y. PubMed PMID: 33589584; PubMed Central PMCID: PMC7884723. Propson NE, Roy ER, Litvinchuk A, Köhl J, Zheng H. Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging. J Clin Invest. 2021 Jan 4;131(1). doi: 10.1172/JCI140966. PubMed PMID: 32990682; PubMed Central PMCID: PMC7773352. Fang Y, Wang L, Wan C, Sun Y, Van der Jeught K, Zhou Z, Dong T, So KM, Yu T, Li Y, Eyvani H, Colter AB, Dong E, Cao S, Wang J, Schneider BP, Sandusky GE, Liu Y, Zhang C, Lu X, Zhang X. MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation. J Clin Invest. 2021 Jan 4;131(1). doi: 10.1172/JCI140837. PubMed PMID: 32990678; PubMed Central PMCID: PMC7773365. Jiang X, Chen J, Wang MC, Wang J. Glutathione Quantification in Live Cells with Real-Time Imaging and Flow Cytometry. STAR Protoc. 2020 Dec 18;1(3):100170. doi: 10.1016/j.xpro.2020.100170. eCollection 2020 Dec 18. PubMed PMID: 33377064; PubMed Central PMCID: PMC7757364. Ghosh A, Comerota MM, Wan D, Chen F, Propson NE, Hwang SH, Hammock BD, Zheng H. An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease. Sci Transl Med. 2020 Dec 9;12(573). doi: 10.1126/scitranslmed.abb1206. PubMed PMID: 33298560; PubMed Central PMCID: PMC7784555. Zhao Q, Gao SM, Wang MC. Molecular Mechanisms of Lysosome and Nucleus Communication. Trends Biochem Sci. 2020 Nov;45(11):978-991. doi: 10.1016/j.tibs.2020.06.004. Epub 2020 Jul 2. Review. PubMed PMID: 32624271; PubMed Central PMCID: PMC7572682. Guo WH, Qi X, Yu X, Liu Y, Chung CI, Bai F, Lin X, Lu D, Wang L, Chen J, Su LH, Nomie KJ, Li F, Wang MC, Shu X, Onuchic JN, Woyach JA, Wang ML, Wang J. Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry. Nat Commun. 2020 Aug 26;11(1):4268. doi: 10.1038/s41467-020-17997-6. PubMed PMID: 32848159; PubMed Central PMCID: PMC7450057. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 May;21(5):513-524. doi: 10.1038/s41590-020-0654-0. Epub 2020 Apr 13. PubMed PMID: 32284594; PubMed Central PMCID: PMC7523413.