个人简介

Malcolm McLeod graduated from Monash University with a BSc (hons) and received a DPhil from the University of Cambridge. He has since held positions at The Australian National University (1997-1998), The University of Sydney (1998-2007) before his appointment as Senior Lecturer at The Research School of Chemistry. Malcolm was promoted to Associate Professor in 2012. He was awarded the Rennie Memorial Medal of the Royal Australian Chemical Institute (2005) and the Biota Medal for Medicinal Chemistry of the Royal Australian Chemical Institute (2007).

研究领域

Anti-doping and medicinal chemistry

Anti-doping chemistry Drug metabolism and metabolite profiling Medicinal chemistry Nicotinic acetylcholine receptors

近期论文

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Cawley, A, Blakey, K, Waller, C et al 2016, 'Detection and metabolic investigations of a novel designer steroid: 3-chloro-17?±-methyl-5?±-androstan-17?2-ol', Drug Testing and Analysis, vol. XXX, no. XXX, pp. XXX. Waller, C, Cawley, A, Suann, C et al 2016, 'In vivo and in vitro metabolism of the designer anabolic steroid furazadrol in thoroughbred racehorses', Journal of Pharmaceutical and Biomedical Analysis, vol. 124, pp. 198-206. Gallagher, R, Chebib, M, Balle, T et al 2015, 'Thiol-Reactive Analogues of Galanthamine, Codeine, and Morphine as Potential Probes to Interrogate Allosteric Binding within Nicotinic Acetylcholine Receptors', Australian Journal of Chemistry, vol. 68, no. 12, pp. 1834-1841. Stevenson, B, Waller, C, Ma, P et al 2015, 'Pseudomonas aeruginosa arylsulfatase: A purified enzyme for the mild hydrolysis of steroid sulfates', Drug Testing and Analysis, (www.drugtestinganalysis.com) DOI 10.1002/dta.1782 Indurthi, D, Pera, E, Kim, H et al 2014, 'Presence of multiple binding sites on ?±9?±10 nAChR receptors alludes to stoichiometric-dependent action of the ?±-conotoxin, Vc1.1', Biochemical Pharmacology, vol. 89, no. 1, pp. 131-140. Ma, P, Kanizaj, N, Chan, S et al 2014, 'The Escherichia coli glucuronylsynthase promoted synthesis of steroid glucuronides: improved practicality and broader scope', Organic and Biomolecular Chemistry, vol. 12, no. 32, pp. 6208-6214. Waller, C & McLeod, M 2014, 'A simple method for the small scale synthesis and solid-phase extraction purification of steroid sulfates', Steroids, vol. 92, pp. 74-80. Masruri, M, Kanizaj, N & McLeod, M 2014, 'Diastereoselective osmium-catalyzed vicinal oxyamination of acyclic allylic alcohol derivatives', Chirality, vol. 26, no. 11, pp. 724-733. McKinney, A, Cawley, A, Young, E et al 2013, 'The metabolism of anabolic-androgenic steroids in the greyhound', Bioanalysis, vol. 5, no. 7, pp. 769-781. Absalom, N, Quek, G, Lewis, T et al 2013, 'Covalent trapping of methyllycaconitine at the a4-a4 interface of the a4b2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed', Journal of Biological Chemistry, vol. 288, no. 37, pp. 26521-26532. Pasfield, L, De La Cruz Rodriguez, L et al 2013, 'Synthesis of (?±)-panduratin A and related natural products using the high pressure Diels-Alder reaction', Asian Journal of Organic Chemistry, vol. 2, no. 1, pp. 60-63. McKinney, A, Smart, C, Keledjian, J et al 2012, 'A GC-MS/MS screening procedure for synthetic anabolic-androgenic steroids in the greyhound', International Conference of Racing Analysts and Veterinarians 2010, ed. Beresford G.D. and Howitt R.G., Dunmore Publishing ltd, Auckland New Zealand, pp. 177-183. McKinney, A, Young, E, Cunnington, K et al 2012, 'The metabolism of synthetic anabolic-androgenic steroids in the greyhound: nandrolone laurate and methandriol dipropionate', International Conference of Racing Analysts and Veterinarians 2010, ed. Beresford G.D. and Howitt R.G., Dunmore Publishing ltd, Auckland New Zealand, pp. 423-430. Ambrus, J, Halliday, J, Kanizaj, N et al 2012, 'Covalent attachment of antagonists to the ?±7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides', Chemical Communications, vol. 48, no. 53, pp. 6699-6701. Masruri, Willis, A & McLeod, M 2012, 'Osmium-catalyzed vicinal oxyamination of alkenes by N-(4- toluenesulfonyloxy)carbamates', Journal of Organic Chemistry, vol. 77, no. 19, pp. 8480-8491. Premraj, R, McLeod, M, et al 2012, 'A total synthesis of herboxidiene methyl ester', Heterocycles, vol. 85, no. 12, pp. 2949-2976. Wilkinson, S, Watson, M, Willis, A et al 2011, 'Experimental and kinetic studies of the Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of glucuronide conjugates', Journal of Organic Chemistry, vol. 76, no. 7, pp. 1992-2000. Paterson, I, Doughty, V, McLeod, M et al 2011, 'Stereocontrolled total synthesis of (+)-concanamycin F: the strategic use of boron-mediated aldol reactions of chiral ketones', Tetrahedron, vol. 67, no. 52, pp. 10119-10128. Quek, G, Lin, D, Halliday, J et al 2010, 'Identifying the binding site of novel methyllycaconitine (MLA) analogs at ?±4?22 nicotinic acetylcholine receptors', A C S Chemical Neuroscience, vol. 1, no. 12, pp. 796-809. Halliday, J, Chebib, M & McLeod, M 2010, 'Synthesis and biological evaluation of a new family of constrained azabicyclic homocholine analogues', Australian Journal of Chemistry, vol. 63, no. 5, pp. 808-812.