个人简介

Thomas Huber received his Diploma of Chemistry from the Technical University Munich and completed his PhD at ETH-Zurich. He has since held positions in physical chemistry at ETH-Zurich (1997), in the Supercomputer Facility at ANU (1998-2000), in the Department of Mathematics at UQ (2001-2005) and in the School of Molecular Bioscience at UQ (2006-2010) before his appointment as an Associate Professor and Future Fellow (2010-2014) at the Research School of Chemistry. Thomas was appointed Professor in 2013

研究领域

Computational structural biology

Structural bioinformatics is a highly cost-efficient solution for accelerated determination of the three-dimensional (3D) structure of proteins and protein-protein complexes from a minimal set of experimental data. The ultimate goal is to understand the delicately balanced, dynamic interactions between different molecules which form the basis of life and also offer key points for pharmaceutical intervention. The computational structural biology group develops innovative tools to determine the 3D structure of biological macromolecules form sparse experimental data of different length scale.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Yang, Y, Huang, F, Huber, T et al 2016, 'Site-specific tagging proteins with a rigid, small and stable transition metal chelator, 8-hydroxyquinoline, for paramagnetic NMR analysis', Journal of Biomolecular NMR, vol. 64, no. 2, pp. 103-113. Pilla, K, Otting, G & Huber, T 2016, 'Pseudocontact Shift-Driven Iterative Resampling for 3D Structure Determinations of Large Proteins', Journal of Molecular Biology, vol. 428, no. 2, pp. 522-532. Chen, J, Yang, Y, Zhang, L et al 2016, 'Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy', Physical Chemistry Chemical Physics, vol. 18, no. 8, pp. 5850-5859. Chen, W, Nitsche, P, Pilla, K et al 2016, 'Sensitive NMR Approach for Determining the Binding Mode of Tightly Binding Ligand Molecules to Protein Targets', Journal of the American Chemical Society, vol. 138, no. 13, pp. 4539-4546. Porter, J, Boon, P, Murray, T et al 2015, 'Directed evolution of new and improved enzyme functions using an evolutionary intermediate and multi-directional search', ACS chemical biology, vol. 10, no. 2, pp. 611-621. Chen, W, Kuppan, K, Lee, M et al 2015, 'O-tert-Butyltyrosine, an NMR tag for high-molecular weight systems and measurements of submicromolar ligand binding affinities', Journal of the American Chemical Society, vol. 137, no. 13, pp. 4581-4586. Pilla, K, Leman, J, Otting, G et al 2015, 'Capturing Conformational States in Proteins Using Sparse Paramagnetic NMR Data', PLOS ONE (Public Library of Science), vol. 10, no. 5, pp. e0127053/1-16. Zhao, Y, Soh, T, Chan, K et al 2015, 'Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication', Journal of Virology, vol. 89, no. 20, pp. 10717-10721. Edwards, D, Huber, T, Hussain, S et al 2014, 'Determining the oligomeric structure of proteorhodopsin by Gd3+-based pulsed dipolar spectroscopy of multiple distances', Structure, vol. 22, no. 11, pp. 1677-1686. Shishmarev, D, Wang, Y, Mason, C et al 2014, 'Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy', Nucleic Acids Research, vol. 42, no. 4, pp. 2750-2757. Skarshewski, A, Stanton-Cook, M, Huber, T et al 2014, 'uPEPperoni: an online tool for upstream open reading frame location and analysis of transcript conservation', BMC Bioinformatics, vol. 15, no. 36, pp. 1-6. Milthorpe, J, Rendell, A P & Huber, T 2014, 'PGAS-FMM: Implementing a distributed fast multipole method using the X10 programming language', Concurrency and Computation: Practice and Experience, vol. 26, issue 3, pp. 712-727. doi:10.1002/cpe.3039 Matalon, E, Huber, T, Hagelueken, G et al 2013, 'Gadolinium(III) spin labels for high-sensitivity distance measurements in transmembrane helices', Angewandte Chemie International Edition, vol. 52, no. 45, pp. 11831-11834. Loh, C, Ozawa, K, Tuck, K et al 2013, 'Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins', Bioconjugate Chemistry, vol. 24, no. 2, pp. 260-268. Kaminker, I, Tkach, I, Manukovsky, N et al 2013, 'W-band orientation selective DEER measurements on a Gd3+/nitroxide mixed-labeled protein dimer with a dual mode cavity', Journal of Magnetic Resonance, vol. 227, pp. 66-71. Jergic, S, Horan, N, Elshenawy, M et al 2013, 'A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode', EMBO Journal, The, vol. 32, no. 9, pp. 1322-1333. Li, J, Pilla, K.B, Li, Q et al 2013, 'Magic angle spinning NMR structure determination of proteins from pseudocontact shifts', Journal of the American Chemical Society, vol. 135, no. 22, pp. 8294-8303. Ozawa, K, Horan, N, Robinson, A et al 2013, 'Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits alpha, epsilon, theta and beta reveals a highly flexible arrangement of the proofreading domain', Nucleic Acids Research, vol. 41, no. 10, pp. 5354-5367. Yagi, H, Pilla, K, T, Maleckis, A et al 2013, 'Three-dimensional protein fold determination from backbone amide pseudocontact shifts generated by lanthanide tags at multiple sites', Structure, vol. 21, no. 6, pp. 883-890. Banerjee, D, Yagi, H, Huber, T et al 2012, 'Nanometer-range distance measurement in a protein using Mn2+ tags', Journal of Physical Chemistry Letters, vol. 3, no. 2, pp. 157-160.