个人简介

Chris Easton is a graduate of Flinders University and the University of Adelaide. He held positions at Harvard University (1980-1981), the Research School of Chemistry (1982), the University of Canterbury (1983-1986) and the University of Adelaide (1986-1994), before his appointment as a Senior Fellow in the Research School of Chemistry, in 1995. He was awarded a D.Sc. from the University of Adelaide in 1998 and is the recipient of the Royal Australian Chemical Institute Birch Medal for 2000, and the Archibald Ollé Prize for Chemical Literature for 2000. He was promoted to Professor at the Research School of Chemistry in 2001 and elected as a Fellow of the Australian Academy of Science in 2004. He is also the Graduate Studies Convenor for Chemistry

研究领域

Biochemical reactions & molecular recognition

We analyse chemical reactions, particularly those occurring in biochemical systems, in order to develop new synthetic methods and to produce physiologically active compounds with potential as pharmaceuticals. We are also interested in the assembly of supramolecular systems. We design and synthesise molecules to modify the systems for useful purposes. Our work in this area has already resulted in pharmaceutical formulations that are in everyday clinical use worldwide. This chemistry also has applications in the development of molecular devices such as catalysts, reactors and photochemical and thermal switches.

近期论文

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Liutkus, M, Fraser, S, Caron, K et al 2016, 'Peptide Synthesis through Cell-Free Expression of Fusion Proteins Incorporating Modified Amino Acids as Latent Cleavage Sites for Peptide Release', ChemBioChem, vol. 17, pp. 908-912. Chan, B, Karton, A, Easton, C et al 2016, '?±-Hydrogen Abstraction by .OH and .SH Radicals from Amino Acids and Their Peptide Derivatives', Journal of Chemical Theory and Computation (JCTC), vol. 12, no. 4, pp. 1606-1613. Wong, A, Little, M, Caldicott, D et al 2015, 'Analytically confirmed recreational use of Phenibut (?2-phenyl-?3-aminobutyric acid) bought over the internet', Clinical Toxicology (Taylor & Francis), vol. 2015, no. 53, pp. 783-784. Amos, R, Easton, C, Heinroth, F et al 2015, 'Hydrogen from Formic Acid via Its Selective Disproportionation over Nanodomain-Modified Zeolites', ACS Catalyisis, vol. 5, no. 7, pp. 4353-4362. Balotra, S, Newman, J, Cowieson, N et al 2015, 'X-ray structure of the amidase domain of AtzF, the allophanate hydrolase from the cyanuric acid-mineralizing multienzyme complex', Applied and Environmental Microbiology, vol. 81, no. 2, pp. 470-480. Fraser, S & Easton, C 2015, 'Biosynthetic incorporation of fluorinated amino acids into peptides and proteins', Australian Journal of Chemistry, vol. 68, no. 1, pp. 9-12. Amos, R, Chan, B, Easton, C et al 2015, 'Hydrogen-atom abstraction from a model amino acid: dependence on the attacking radical', Journal of Physical Chemistry B, vol. 119, no. 3, pp. 783-788. Pham, D, Nguyen, H, Lincoln, S et al 2015, 'Complexation of dodecyl-substituted poly(acrylate) by linked ?2-cyclodextrin dimers and trimers in aqueous solution', Polymer Science - Series A, vol. 53, no. 10, pp. 1278-1286. Chan, B, Radom, L & Easton, C 2015, 'Outcome-changing effect of polarity reversal in hydrogen-atom-abstraction reactions', Journal of Physical Chemistry A, vol. 119, no. 16, pp. 3843-3847. Amos, R, Heinroth, F, Chan, B et al 2015, 'Hydrogen from Formic Acid via Its Selective Disproportionation over Nanodomain-Modified Zeolites', ACS Catalyisis, vol. 5, no. 7, pp. 4353-4362. Wong, A, Little, M, Caldicott, D et al 2015, 'Analytically confirmed recreational use of Phenibut (?2-phenyl-?3-aminobutyric acid) bought over the internet', Clinical Toxicology (Taylor & Francis), vol. 2015, no. 53, pp. 783-784. Loh, K, Onagi, H, Easton, C et al 2015, 'A Cyclodextrin-Based Photoresponsive Molecular Gate that Functions Independently of Either Solvent or Potentially Competitive Guests', Chemistry - An Asian Journal, vol. 10, no. 11, pp. 2328-2332. Alissandratos, A & Easton, C 2015, 'Biocatalysis for the application of CO2 as a chemical feedstock', Beilstein Journal of Organic Chemistry, vol. 11, pp. 2370-2387. Alissandratos, A, Kim, H & Easton, C 2014, 'Formate production through carbon dioxide hydrogenation with recombinant whole cell biocatalysts', Bioresource Technology, vol. 164, pp. 7-11. Amos, R, Heinroth, F, Chan, B et al 2014, 'Hydrogen from formic acid through its selective disproportionation over sodium germanate - a non-transition-metal catalysis system', Angewandte Chemie International Edition, vol. 53, no. 42, pp. 11275-11279. Alissandratos, A, Kim, H, Matthews, H et al 2013, 'Clostridium carboxidivorans strain P7T recombinant formate dehydrogenase catalyzes reduction of CO2 to formate', Applied and Environmental Microbiology, vol. 79, no. 2, pp. 741-744. Nguyen, H, Pham, D, Lincoln, S et al 2013, 'Host-guest chemistry of linked ?2-cyclodextrin trimers and adamantyl substituted poly(acrylate)s in aqueous solution', Polymer Chemistry, vol. 4, no. 3, pp. 820-829. Philbrook, A, Earnshaw, S, Easton, C et al 2013, 'Co-polymerization analysis of thermosetting resins using 1H-15N-13C triple resonance NMR spectroscopy', Journal of Applied Polymer Science, vol. 128, no. 5, pp. 3375-3381. Cao, F & Easton, C 2013, 'Production and regulation of levels of amidated peptide hormones', Australian Journal of Chemistry, vol. 66, no. 3, pp. 297-307. Easton, C, ed., 2013, Beckwith memorial symposium on free radical chemistry.