个人简介

Since July 2013, John A. Carver has been Director of the Research School of Chemistry at the Australian National University in Canberra. He undertook his undergraduate (First-class Honours) degree in Chemistry at the University of Adelaide. In 1983, he was awarded his Ph.D. in Biological Chemistry from the Australian National University and subsequently undertook post-doctoral studies in Biochemistry at the Universities of Oxford and Adelaide. In 1988, John took up a position as Lecturer in Chemistry at the University of Wollongong where he subsequently became an Associate Professor. In early 2004, he returned to the University of Adelaide as Professor of Chemistry and Head of the School of Chemistry and Physics. In 2008, he became the Deputy Executive Dean of the Faculty of Sciences and, for all of 2009, he was also Head of the School of Molecular and Biomedical Science.

研究领域

Protein structure, function and interactions

John’s research interests are in peptide and protein structure, function and interactions. Of late, he has been concentrating on molecular chaperone proteins and their mechanism of stabilizing other proteins, particularly those involved in diseases of protein aggregation, e.g. Alzheimer’s and Parkinson’s diseases and cataract. Related to this, he is also very interested in the mechanism of protein aggregation and its mitigation. He utilises a diversity of spectroscopic, biophysical and protein chemical techniques for his research, with NMR spectroscopy being at the forefront. He has co-authored over 150 research publications and has received a variety of fellowships.

近期论文

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J.H. Bradbury, J.A. Carver and M.W. Parker. Histidine H-2 NMR resonances of sperm whale oxy-, carbonyl- and met-mygolobins. J. Chem. Soc. Chem. Commun., 208-209 (1981). J.H. Bradbury, J.A. Carver and M.W. Parker. Assignments of meso 1H NMR resonances in haem proteins by selective deuteration. FEBS Lett. 146, 297-300 (1982). J.A. Carver and J.H. Bradbury. Assignments of 1H NMR resonances of histidine and other aromatic residues in met, cyano, oxy and carbon monoxy myoglobins. Biochemistry 23, 4890-4905 (1984). J.H. Bradbury and J.A. Carver. Conformational differences between various myoglobin ligated states as monitored by 1H NMR spectroscopy. Biochemistry 23, 4905-4913 (1984). J.A. Carver, R.M. Cooke, G. Esposito, I.D. Campbell, H. Gregory and B. Sheard. High-resolution 1H NMR study of the solution structure of human epidermal growth factor. FEBS Lett. 205, 77-81 (1986). G. Esposito, J.A. Carver, J. Boyd and I.D. Campbell. High-resolution 1H NMR study of the solution structure of alamethicin. Biochemistry 26, 1043-1050 (1987). M.F. Moody, P.T. Jones, J.A. Carver, J. Boyd and I.D. Campbell. 1H NMR studies of an integral membrane protein: subunit c of the F1F0 ATP synthase. J. Mol. Biol. 193, 759-774 (1987). S. Hasthorpe, J.A. Carver, D. Rees and I.D. Campbell. Metabolic effects of interleukin 3 on 32D C123 cells analysed by NMR. J. Cell Physiol. 133, 351-357 (1987). J.A. Carver. The conformation of bombesin in solution as determined by two-dimensional 1H NMR techniques. Eur. J. Biochem. 168, 193-199 (1987). J.A. Carver. A two-dimensional 1H NMR study of the solution conformation of gastrin releasing peptide. Biochem. Biophys. Res. Commun. 150, 552-560 (1988). R. Bazzo, M.J. Tappin, A. Pastore, T.S. Harvey, J.A. Carver and I.D. Campbell. The structure of melittin. A 1H NMR study in methanol. Eur. J. Biochem. 173, 139-146 (1988). J.A. Carver, G.S. Baldwin, D.B. Keech, R. Bais and J.C. Wallace. Inactivation of chicken liver pyruvate carboxylase by 1,10-phenanthroline. Biochem. J. 252, 501-507 (1988). J. Barber, J.A. Carver, R. Leberman and G.M.V. Tebb. The molecular basis of Kirromycin (Mocimycin) action; A 1H NMR study using deuterated elongation Factor Tu. J. Antibiotics 41, 202-206 (1988). S.E. Gargosky, J.A. Carver, J.C. Wallace, F.M. Upton and F.J. Ballard. Structure-function studies on bombesin and related peptides: their biological effects on Swiss 3T3 cells and two-dimensional 1H NMR analysis. Ann. N. Y. Acad. Sci. 547, 481-483 (1988). V. Liokas, M.J. Garson and J.A. Carver. A new furanosesterpene from the marine sponge Psammocinia rugosa. Aust. J. Chem. 42, 1805-1811 (1989). J.A. Carver and J.G. Collins. NMR identification of a partial helical conformation for bombesin in solution. Eur. J. Biochem. 187, 645-650 (1990). M.G. Nonato, M.J. Garson, J.A. Carver and R.J.W. Truscott. 1H NMR assignments of anonaine and xylopine derivatives from Talauma gitingensis. J. Nat. Prod. 53, 1623-1627 (1990). R.J.W. Truscott, J.A. Carver, A. Thorpe and R.H. Douglas. Identification of 3-hydroxykynurenine as the lens pigment in the gourami Trichogaster trichopterus. Exp. Eye Res. 54, 1015-1017 (1992). J.A. Carver, J.A. Aquilina, R.J.W. Truscott and G.B. Ralston. Identification by 1H NMR spectroscopy of flexible C-terminal extensions in bovine lens a-crystallin. FEBS Lett. 311, 143-149 (1992). J.A. Carver, N.H. Rees, D.L. Turner, S. Senior and B.Z. Chowdry. NMR studies of the Na+, Mg2+ and Ca2+ complexes of cyclosporin A. J. Chem. Soc. Chem. Commun., 1682-1684 (1992).