个人简介
Postdoctoral Research Fellow, UNSW Australia (2014-2015)
Postdoctoral Research Officer, Westmead Children's Hospital (2011-2014)
Doctor of Philosophy, Faculty of Engineering, University of Sydney (2011)
研究领域
Dr Nicole Yu is a Research Fellow in the MechBio Lab at the Graduate School of Biomedical Engineering. Her research interests lie at the interface of tissue engineering and mechanobiology, focusing on the regenerative power of the periosteum. The periosteum is a 'smart' membrane enveloping the bone that also provides a niche for regenerative stem cells, such as periosteum-derived stem cells. Nicole is developing experimental models to understand how our body's intrinsic mechanical cues can drive tissue genesis. These new insights will facilitate the design of next generation implants, which stimulate bone tissue genesis through delivery of stem cells and biological factors. Nicole has a strong multidisciplinary foundation in bone tissue engineering and pre-clinical testing of drug-eluting biomaterials for bone healing.
近期论文
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Moore SR; Heu C; Yu NY; Whan RM; Knothe UR; Milz S; Knothe Tate ML, 2016, 'Translating Periosteum's Regenerative Power: Insights From Quantitative Analysis of Tissue Genesis With a Periosteum Substitute Implant.', Stem cells translational medicine, http://dx.doi.org/10.5966/sctm.2016-0004
Bellemore JM; Carpenter EC; Yu NYC; Birke O; Little DG, 2016, 'Biomechanics of Slipped Capital Femoral Epiphysis', Journal of Pediatric Orthopaedics, vol. 36, no. 6, pp. 651 - 655, http://dx.doi.org/10.1097/BPO.0000000000000512
Yu NYC; Fathi A; Murphy CM; Mikulec K; Peacock L; Cantrill LC; Dehghani F; Little DG; Schindeler A, 2015, 'Local co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(d,l-lactide-co-glycolide) nanospheres', Journal of Biomedical Materials Research Part B: Applied Biomaterials, http://dx.doi.org/10.1002/jbm.b.33481
Schindeler A; Yu NYC; Cheng TL; Sullivan K; Mikulec K; Peacock L; Matthews R; Little DG, 2015, 'Local Delivery of the Cationic Steroid Antibiotic CSA-90 Enables Osseous Union in a Rat Open Fracture Model of Staphylococcus aureus Infection', Journal of Bone and Joint Surgery: American Volume, vol. 97, no. 4, pp. 302 - 309, http://dx.doi.org/10.2106/JBJS.N.00840
Morse A; Yu NYC; Peacock L; Mikulec K; Kramer I; Kneissel M; McDonald MM; Little DG, 2015, 'Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength', Bone, vol. 71, pp. 155 - 163, http://dx.doi.org/10.1016/j.bone.2014.10.018
Yu NYC; Schindeler A; Fitzpatrick J; Gdalevitch M; Mikulec K; Peacock L; Cantrill L; Ruys AJ; Murphy CM; Cooper-White JJ; Little DG; Knothe Tate ML, 2014, 'Exogenous and endogenous optimisation of in situ osteogenesis using biochemical and/or mechanical factors', IBMS BoneKEy, vol. 11, pp. S1 - S71, http://dx.doi.org/10.1038/bonekey.2014.71
Murphy CM; Schindeler A; Gleeson JP; Yu NYC; Cantrill LC; Mikulec K; Peacock L; O'Brien FJ; Little DG, 2014, 'A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates', Acta Biomaterialia, vol. 10, no. 5, pp. 2250 - 2258, http://dx.doi.org/10.1016/j.actbio.2014.01.016
Yu NYC; Gdalevitch M; Murphy CM; Mikulec K; Peacock L; Fitzpatrick J; Cantrill LC; Ruys AJ; Cooper-White JJ; Little DG; Schindeler A, 2014, 'Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic RHBMP-2 and anti-resorptive agents', European Cells and Materials, vol. 27, pp. 98 - 111
Yu NYC; Schindeler A; Peacock L; Mikulec K; Ruys AJ; Little DG, 2012, 'Manipulating the anabolic and catabolic responses for bone tissue engineering', Journal of Bone & Joint Surgery, British Volume, vol. 94-B, no. Suppl XXIII, pp. 130, http://www.bjjprocs.boneandjoint.org.uk/content/94-B/SUPP_XXIII/130.abstract
Carr D; Yu NYC; Fitzpatrick J; Peacock L; Mikulec K; Ruys AJ; Cooper-White JC; Little DG; Schindeler A, 2012, 'Synergy between Rhbmp-2 and IKK-Inhibitor PS-1145 Delivered via a Porous Biodegradable Polymer Implant', Journal of tissue science & engineering, vol. 05, no. 01, http://dx.doi.org/10.4172/2157-7552.S1-003
Yu NYC; Schindeler A; Tägil M; Ruys AJ; Little DG, 2012, 'Use of BMPs and bisphosphonates to improve bone fracture healing', Frontiers in Bioscience - Elite, vol. 4 E, no. 7, pp. 2647 - 2653
Yu NYC; Schindeler A; Peacock L; Mikulec K; Fitzpatrick J; Ruys AJ; Cooper-White JJ; Little DG, 2012, 'Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation', European Cells and Materials, vol. 25, pp. 190 - 203
El-Hoss J; Sullivan K; Cheng T; Yu NYC; Bobyn JD; Peacock L; Mikulec K; Baldock P; Alexander IE; Schindeler A; Little DG, 2012, 'A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells', Journal of Bone and Mineral Research, vol. 27, no. 1, pp. 68 - 78, http://dx.doi.org/10.1002/jbmr.528
McDonald MM; Morse A; Mikulec K; Peacock L; Yu N; Baldock PA; Birke O; Liu M; Ke HZ; Little DG, 2012, 'Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats', Journal of Orthopaedic Research, vol. 30, no. 10, pp. 1541 - 1548, http://dx.doi.org/10.1002/jor.22109
Bobyn JD; Rash A; Peacock L; Yu NYC; Schindeler A, 2011, 'The contribution of soft tissue osteoprogenitors to spinal fusion', Osteoporosis International, vol. 22, no. S4, pp. 521 - 559, http://dx.doi.org/10.1007/s00198-011-1715-x
Schindeler A; Birke O; Yu NYC; Morse A; Ruys A; Baldock PA; Little DG, 2011, 'Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate', Journal of Bone and Joint Surgery: British Volume, vol. 93 B, no. 8, pp. 1134 - 1139, http://dx.doi.org/10.1302/0301-620X.93B8.25940
Birke O; Liu R; McDonald M; Morse A; Yu N; Schindeler A; Little D, 2010, 'Muscle cell contribution to intramembranous bone healing in a metaphyseal defect model in mice', Bone, vol. 46, pp. S45 - S45, http://dx.doi.org/10.1016/j.bone.2010.01.101
Birke O; Schindeler A; Ramachandran M; Peacock L; Mikulec K; Morse A; Yu N; Baldock P; Cowell C; Munns C; Bellemore M; Little D, 2010, 'Treatment of congenital pseudarthrosis of the tibia using recombinant bone morphogenetic protein and bisphosphonates', Bone, vol. 46, pp. S20 - S21, http://dx.doi.org/10.1016/j.bone.2010.01.038
Yu NYC; Schindeler A; Little DG; Ruys AJ, 2010, 'Biodegradable poly(α-hydroxy acid) polymer scaffolds for bone tissue engineering', Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 93, no. 1, pp. 285 - 295, http://dx.doi.org/10.1002/jbm.b.31588
Schindeler A; Morse A; Peacock L; Mikulec K; Yu NYC; Liu R; Kijumnuayporn S; McDonald MM; Baldock PA; Ruys AJ; Little DG, 2010, 'Rapid cell culture and pre-clinical screening of a transforming growth factor-Β (TGF-Β) inhibitor for orthopaedics', BMC Musculoskeletal Disorders, vol. 11, http://dx.doi.org/10.1186/1471-2474-11-105
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