研究领域

Biochemistry, Biomedical Engineering, Cell Biology and Gene Regulation, Cardiology and Vascular Disease, Proteomics

Tissue repair and regeneration involves interactions between the extracellular environment that binds growth signals and guides cell and tissue behavior. The activity of these signals is controlled by glycosylated molecules known as proteoglycans and this is my central area of research interest.

近期论文

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Hayes AJ; Shu CC; Lord MS; Little CB; Whitelock JM; Melrose J, 2016, 'Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc', European Cells and Materials, vol. 32, pp. 40 - 57 Lord MS; Farrugia BL; Yan CMY; Vassie JA; Whitelock JM, 2016, 'Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts', Journal of Biomedical Materials Research Part A, http://dx.doi.org/10.1002/jbm.a.35704 Farrugia BL; Whitelock JM; O Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, vol. 64, no. 2, pp. 85 - 98, http://dx.doi.org/10.1369/0022155415620649 Farrugia BL; Chandrasekar K; Johnson L; Whitelock JM; Marks DC; Irving DO; Lord MS, 2016, 'Perspectives on the use of biomaterials to store platelets for transfusion', Biointerphases: an open access journal for the biomaterials interface community, vol. 11, no. 2, http://dx.doi.org/10.1116/1.4952450 Lord MS; Farrugia BL; Yan CMY; Vassie JA; Whitelock JM, 2016, 'Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts', Journal of Biomedical Materials Research Part A, vol. 104, no. 7, pp. 1736 - 1746, http://dx.doi.org/10.1002/jbm.a.35704 Shu CC; Jackson MT; Smith MM; Smith SM; Penm S; Lord MS; Whitelock JM; Little CB; Melrose J, 2016, 'Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis', Arthritis & Rheumatology, vol. 68, no. 4, pp. 868 - 879, http://dx.doi.org/10.1002/art.39529 Farrugia BL; Whitelock JM; O Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, vol. 64, no. 2, pp. 85 - 98, http://dx.doi.org/10.1369/0022155415620649 Dos Santos M; Michopoulou A; André-Frei V; Boulesteix S; Guicher C; Dayan G; Whitelock J; Damour O; Rousselle P, 2016, 'Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin.', Aging, vol. 8, no. 4, pp. 751 - 768, http://dx.doi.org/10.18632/aging.100928 Melrose J; Shu C; Whitelock JM; Lord MS, 2016, 'The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation', Matrix Biology, vol. 52-54, pp. 363 - 383, http://dx.doi.org/10.1016/j.matbio.2016.01.008 Shawky MS; Ricciardelli C; Lord M; Whitelock J; Ferro V; Britt K; Thompson EW, 2015, 'Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk', Journal of Mammary Gland Biology and Neoplasia, vol. 20, no. 3-4, pp. 121 - 131, http://dx.doi.org/10.1007/s10911-015-9346-z Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2015, 'Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?', Molecules, vol. 20, no. 3, pp. 4254 - 4276, http://dx.doi.org/10.3390/molecules20034254 Gunatillake T; Chui A; Lord M; Whitelock J; Murthi P; Ignatovic V; Monagle P; Brennecke S; Said J, 2015, '[289-POS]: Placental heparan sulphate glycosaminoglycans in pre-eclampsia.', Pregnancy Hypertension, vol. 5, no. 1, pp. 144, http://dx.doi.org/10.1016/j.preghy.2014.10.295 Lord MS; Farrugia BL; Rnjak-Kovacina J; Whitelock JM, 2015, 'Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix', Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare, vol. 15, no. 1, pp. 77 - 95, http://dx.doi.org/10.1586/14737159.2015.979158 Vassie JA; Whitelock JM; Lord MS, 2015, 'Glycosaminoglycan functionalized nanoparticles exploit glycosaminoglycan functions.', Methods in Molecular Biology, vol. 1229, pp. 557 - 565, http://dx.doi.org/10.1007/978-1-4939-1714-3_44 Lord MS; Whitelock JM; Simmons A; Williams RL; Milthorpe BK, 2014, 'Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography', Biointerphases: an open access journal for the biomaterials interface community, vol. 9, no. 4, pp. 041002, http://dx.doi.org/10.1116/1.4900993 Lord MS; Whitelock JM, 2014, 'Bioengineered heparin: Is there a future for this form of the successful therapeutic?', Bioengineered, vol. 5, no. 4, pp. 222 - 226, http://dx.doi.org/10.4161/bioe.29388 Baljinnyam E; Umemura M; Chuang C; De Lorenzo MS; Iwatsubo M; Chen S; Goydos JS; Ishikawa Y; Whitelock JM; Iwatsubo K, 2014, 'Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling', Pigment Cell and Melanoma Research, vol. 27, no. 4, pp. 611 - 620, http://dx.doi.org/10.1111/pcmr.12250 Chui A; Murthi P; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Said JM, 2014, 'Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?', Placenta, vol. 35, no. 8, pp. 596 - 605, http://dx.doi.org/10.1016/j.placenta.2014.05.009 Lord MS; Tsoi BM; Farrugia BL; Simon Ting SR; Baker S; Wiesmann WP; Whitelock JM, 2014, 'Synthesis and characterization of water soluble biomimetic chitosans for bone and cartilage tissue regeneration', Journal of Materials Chemistry B, vol. 20, no. 38, pp. 6517 - 6526, http://dx.doi.org/10.1039/c4tb00531g Lord MS; Jung M; Cheng B; Whitelock JM, 2014, 'Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1', Matrix Biology, vol. 35, pp. 123 - 131, http://dx.doi.org/10.1016/j.matbio.2013.12.005