Lord, Megan - University of New South Wales - Graduate School of Biomedical Engineering

个人简介

Doctor of Philosophy, Graduate School of Biomedical Engineering, The University of New South Wales (2006) Master of Biomedical Engineering, The University of New South Wales (2003) Bachelor of Enginering (Chemical Engineering) Hons I, The University of New South Wales (2003)

研究领域

Dr Lord's research aims to develop materials that replicate components of tissues called extracellular matrix for both the correct function of implantable medical devices that interface with tissues and the controlled repair of tissues as a result of disease or injury. The extracellular matrix provides much of the tissue architecture and acts as a reservoir of chemical signals for tissue development and repair. By mimicking these natural structures with man-made engineered materials and bioengineered molecules her research team have been working towards repairing tissues including blood vessels, skin, bone and cartilage as well as extending the functional life of cochlear electrodes and platelet blood bags.

近期论文

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Hayes AJ; Shu CC; Lord MS; Little CB; Whitelock JM; Melrose J, 2016, 'Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc', European Cells and Materials, vol. 32, pp. 40 - 57 Lord MS; Farrugia BL; Yan CMY; Vassie JA; Whitelock JM, 2016, 'Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts', Journal of Biomedical Materials Research Part A, http://dx.doi.org/10.1002/jbm.a.35704 Lord MS; Cheng B; Tang F; Lyons JG; Rnjak-Kovacina J; Whitelock JM, 2016, 'Bioengineered human heparin with anticoagulant activity.', Metabolic Engineering, vol. 38, pp. 105 - 114, http://dx.doi.org/10.1016/j.ymben.2016.07.006 Farrugia BL; Whitelock JM; O Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, vol. 64, no. 2, pp. 85 - 98, http://dx.doi.org/10.1369/0022155415620649 Farrugia BL; Chandrasekar K; Johnson L; Whitelock JM; Marks DC; Irving DO; Lord MS, 2016, 'Perspectives on the use of biomaterials to store platelets for transfusion', Biointerphases: an open access journal for the biomaterials interface community, vol. 11, no. 2, http://dx.doi.org/10.1116/1.4952450 Chang T; Gosain P; Stenzel MH; Lord MS, 2016, 'Drug-loading of poly(ethylene glycol methyl ether methacrylate) (PEGMEMA)-based micelles and mechanisms of uptake in colon carcinoma cells', Colloids and Surfaces B: Biointerfaces, vol. 144, pp. 257 - 264, http://dx.doi.org/10.1016/j.colsurfb.2016.04.019 Lord MS; Farrugia BL; Yan CMY; Vassie JA; Whitelock JM, 2016, 'Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts', Journal of Biomedical Materials Research Part A, vol. 104, no. 7, pp. 1736 - 1746, http://dx.doi.org/10.1002/jbm.a.35704 Nandakumar D; Bendavid A; Martin PJ; Harris KD; Ruys AJ; Lord MS, 2016, 'Fabrication of Semiordered Nanopatterned Diamond-like Carbon and Titania Films for Blood Contacting Applications', ACS Applied Materials and Interfaces, vol. 8, no. 11, pp. 6802 - 6810, http://dx.doi.org/10.1021/acsami.5b11614 Shu CC; Jackson MT; Smith MM; Smith SM; Penm S; Lord MS; Whitelock JM; Little CB; Melrose J, 2016, 'Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis', Arthritis & Rheumatology, vol. 68, no. 4, pp. 868 - 879, http://dx.doi.org/10.1002/art.39529 An H; Brettle M; Lee T; Heng B; Lim CK; Guillemin GJ; Lord MS; Klotzsch E; Geczy CL; Bryant K; Fath T; Tedla N, 2016, 'Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66', Journal of Cell Science, vol. 129, no. 6, pp. 1198 - 1209, http://dx.doi.org/10.1242/jcs.182006 Farrugia BL; Whitelock JM; O Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, vol. 64, no. 2, pp. 85 - 98, http://dx.doi.org/10.1369/0022155415620649 Chang T; Trench D; Putnam J; Stenzel MH; Lord MS, 2016, 'Curcumin-Loading-Dependent Stability of PEGMEMA-Based Micelles Affects Endocytosis and Exocytosis in Colon Carcinoma Cells', Molecular Pharmaceutics, vol. 13, no. 3, pp. 924 - 932, http://dx.doi.org/10.1021/acs.molpharmaceut.5b00820 Melrose J; Shu C; Whitelock JM; Lord MS, 2016, 'The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation', Matrix Biology, vol. 52-54, pp. 363 - 383, http://dx.doi.org/10.1016/j.matbio.2016.01.008 Shawky MS; Ricciardelli C; Lord M; Whitelock J; Ferro V; Britt K; Thompson EW, 2015, 'Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk', Journal of Mammary Gland Biology and Neoplasia, vol. 20, no. 3-4, pp. 121 - 131, http://dx.doi.org/10.1007/s10911-015-9346-z Chrzanowski W; Lee JH; Kondyurin A; Lord MS; Jang JH; Kim HW; Bilek MMM, 2015, 'Nano-Bio-Chemical Braille for Cells: The Regulation of Stem Cell Responses using Bi-Functional Surfaces', Advanced Functional Materials, vol. 25, no. 2, pp. 193 - 205, http://dx.doi.org/10.1002/adfm.201401696 Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2015, 'Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?', Molecules, vol. 20, no. 3, pp. 4254 - 4276, http://dx.doi.org/10.3390/molecules20034254 Gunatillake T; Chui A; Lord M; Whitelock J; Murthi P; Ignatovic V; Monagle P; Brennecke S; Said J, 2015, '[289-POS]: Placental heparan sulphate glycosaminoglycans in pre-eclampsia.', Pregnancy Hypertension, vol. 5, no. 1, pp. 144, http://dx.doi.org/10.1016/j.preghy.2014.10.295 Chen Y; Lord MS; Piloni A; Stenzel MH, 2015, 'Correlation between molecular weight and branch structure of glycopolymers stars and their binding to lectins', Macromolecules, vol. 48, no. 2, pp. 346 - 357, http://dx.doi.org/10.1021/ma501742v Lord MS; Farrugia BL; Rnjak-Kovacina J; Whitelock JM, 2015, 'Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix', Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare, vol. 15, no. 1, pp. 77 - 95, http://dx.doi.org/10.1586/14737159.2015.979158 Vassie JA; Whitelock JM; Lord MS, 2015, 'Glycosaminoglycan functionalized nanoparticles exploit glycosaminoglycan functions.', Methods in Molecular Biology, vol. 1229, pp. 557 - 565, http://dx.doi.org/10.1007/978-1-4939-1714-3_44