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研究领域

Animal Cell and Molecular Biology, Biochemistry and Cell Biology, Protein Targeting and Signal Transduction, Cell Metabolism

近期论文

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Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, no. 4, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481 Wu LE; Sinclair DA, 2016, 'Restoring stem cells — all you need is NAD+', Cell Research, http://dx.doi.org/10.1038/cr.2016.80 Chowdhury MKH; Wu LE; Coleman JLJ; Smith NJ; Morris MJ; Shepherd PR; Smith GC, 2016, 'Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling', Biochemical Journal, vol. 473, no. 9, pp. 1247 - 1255, http://dx.doi.org/10.1042/BCJ20160121 Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, http://dx.doi.org/10.1111/acel.12481 Cagnone GLM; Tsai TS; Makanji Y; Matthews P; Gould J; Bonkowski MS; Elgass KD; Wong ASA; Wu LE; McKenzie M; Sinclair DA; John JCS, 2016, 'Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep23229 Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie International Edition, vol. 55, no. 5, pp. 1742 - 1745, http://dx.doi.org/10.1002/anie.201509065 Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie International Edition, http://dx.doi.org/10.1002/anie.201509065 Wu LE; Fazakerley DJ; Cantley J, 2015, 'Circulating AFABP promotes insulin secretion', Obesity, vol. 23, no. 8, pp. 1525, http://dx.doi.org/10.1002/oby.21175 Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS One, vol. 10, no. 5, http://dx.doi.org/10.1371/journal.pone.0126194 Ma X; Yang P; Kaplan WH; Lee BH; Wu LE; Yang JYH; Yasunaga M; Sato K; Chisholm DJ; James DE, 2014, 'ISL1 regulates peroxisome proliferator-activated receptor γ activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms', Molecular and Cellular Biology, vol. 34, no. 19, pp. 3607 - 3617, http://dx.doi.org/10.1128/MCB.00583-14 Wu LE; Meoli CC; Mangiafico SP; Fazakerley DJ; Cogger VC; Mohamad M; Pant H; Kang MJ; Powter E; Burchfield JG; Xirouchaki CE; Mikolaizak AS; Stöckli J; Kolumam G; Van Bruggen N; Gamble JR; Le Couteur DG; Cooney GJ; Andrikopoulos S; James DE, 2014, 'Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction', Diabetes, vol. 63, no. 8, pp. 2656 - 2667, http://dx.doi.org/10.2337/db13-1665 North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA; Van Deursen JM; Rosenzweig A; Sinclair DA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', The EMBO Journal, vol. 33, no. 13, pp. 1438 - 1453, http://dx.doi.org/10.15252/embj.201386907 Wu LE; Sinclair DA, 2014, 'SIRT2 controls the pentose phosphate switch', The EMBO Journal, vol. 33, no. 12, pp. 1287 - 1288, http://dx.doi.org/10.15252/embj.201488713 Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, vol. 19, no. 3, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009 Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, vol. 3, no. 4, pp. 465 - 473, http://dx.doi.org/10.1016/j.molmet.2014.02.005 Wu LE; Gomes AP; Sinclair DA, 2014, 'Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis', Cancer Cell, vol. 25, no. 1, pp. 12 - 19, http://dx.doi.org/10.1016/j.ccr.2013.12.005 Van der Poorten D; Samer CF; Ramezani-Moghadam M; Coulter S; Kacevska M; Schrijnders D; Wu LE; Mcleod D; Bugianesi E; Komuta M; Roskams T; Liddle C; Hebbard L; George J, 2013, 'Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?', Hepatology, vol. 57, no. 6, pp. 2180 - 2188, http://dx.doi.org/10.1002/hep.26072 Carter EA; Rayner BS; McLeod AI; Wu LE; Marshall CP; Levina A; Aitken JB; Witting PK; Lai B; Cai Z; Vogt S; Lee YC; Chen CI; Tobin MJ; Harris HH; Lay PA, 2010, 'Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells', Molecular Biosystems, vol. 6, no. 7, pp. 1316 - 1322, http://dx.doi.org/10.1039/c001499k Wu LE; Hocking SL; James DE, 2010, 'Macrophage infiltration and cytokine release in adipose tissue: angiogenesis or inflammation?', Diabetology International, vol. 1, no. 1, pp. 26 - 34, http://dx.doi.org/10.1007/s13340-010-0003-x Hocking SL; Wu LE; Guilhaus M; Chisholm DJ; James DE, 2010, 'Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue-derived microvascular endothelial cells', Diabetes, vol. 59, no. 12, pp. 3008 - 3016, http://dx.doi.org/10.2337/db10-0483

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