研究领域

Neurosciences, Biochemistry and Cell Biology, Animal Physiology - Cell, Receptors and Membrane Biology

Hearing loss is a hidden sensory deficit affecting 1 in 6 Australians, the statistics is alarmingly global. My research aim to discover the role of membrane receptor-mediated cellular signal transduction in hearing. Research techniques include in vivo small animal auditory testing, multi-photon confocal microscopy for immunofluorescence real-time and histological imaging, electrophysiology, and pharmacological treatments. By uncovering the role of receptor signalling pathways in healthy and hearing-loss ears of transgenic mouse models, we gain knowledge on how noise, aging, and drugs affect hearing function. Our ultimate goal is to provide avenues for preventing and restoring hearing to affected individuals.

近期论文

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Froud KE; Wong ACY; Cederholm JME; Klugmann M; Sandow SL; Julien JP; Ryan AF; Housley GD, 2015, 'Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms8115 Wong ACY; Ryan AF, 2015, 'Mechanisms of sensorineural cell damage, death and survival in the cochlea', Frontiers in Aging Neuroscience, vol. 7, http://dx.doi.org/10.3389/fnagi.2015.00058 Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams–Beuren Syndrome', European Journal of Human Genetics, vol. 23, no. 6, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188 Von Jonquieres G; Froud KE; Klugmann CB; Wong ACY; Housley GD; Klugmann M, 2014, 'Loss of central auditory processing in a mouse model of canavan disease', PLoS One, vol. 9, no. 5, http://dx.doi.org/10.1371/journal.pone.0097374 Pinyon JL; Tadros SF; Froud KE; Wong ACY; Tompson IT; Crawford EN; Ko M; Morris R; Klugmann M; Housley GD, 2014, 'Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear', Science Translational Medicine, vol. 6, no. 233, http://dx.doi.org/10.1126/scitranslmed.3008177 Gunewardene N; Guo C; Wong C; Thorne P; Vlajkovic S, 2013, 'Adenosine amine congener ameliorates cisplatin-induced hearing loss', World journal of otorhinolaryngology, vol. 28, no. 3, pp. 100 - 107, http://dx.doi.org/10.5319/wjo.v3.i3.100 Housley GD; Morton-Jones R; Vlajkovic SM; Telang RS; Paramananthasivam V; Tadros SF; Wong ACY; Froud KE; Cederholm JME; Sivakumaran Y; Snguanwongchai P; Khakh BS; Cockayne DA; Thorne PR; Ryan AF, 2013, 'ATP-gated ion channels mediate adaptation to elevated sound levels', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 18, pp. 7494 - 7499, http://dx.doi.org/10.1073/pnas.1222295110 Wong ACY; Froud KE; Hsieh YSY, 2013, 'Noise-induced hearing loss in the 21 st century: A research and translational update', World journal of otorhinolaryngology, vol. 3, no. 3, pp. 58 - 70, http://dx.doi.org/10.5319/wjo.v3.i3.58. Wong ACY; Birnbaumer L; Housley GD, 2013, 'Canonical transient receptor potential channel subtype 3-mediated hair cell Ca2+ entry regulates sound transduction and auditory neurotransmission', European Journal of Neuroscience, vol. 37, no. 9, pp. 1478 - 1486, http://dx.doi.org/10.1111/ejn.12158 Vlajkovic SM; Lin SCY; Wong ACY; Wackrow B; Thorne PR, 2013, 'Noise-induced changes in expression levels of NADPH oxidases in the cochlea', Hearing Research, vol. 304, pp. 145 - 152, http://dx.doi.org/10.1016/j.heares.2013.07.012 Yan D; Zhu Y; Walsh T; Xie D; Yuan H; Sirmaci A; Fujikawa T; Wong ACY; Loh TL; Du L; Grati M; Vlajkovic SM; Blanton S; Ryan AF; Chen ZY; Thorne PR; Kachar B; Tekin M; Zhao HB; Housley GD; King MC; Liu XZ, 2013, 'Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 6, pp. 2228 - 2233, http://dx.doi.org/10.1073/pnas.1222285110 Wong ACY; Velamoor S; Skelton MR; Thorne PR; Vlajkovic SM, 2012, 'Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues', Histochemistry and Cell Biology, vol. 137, no. 5, pp. 599 - 613, http://dx.doi.org/10.1007/s00418-012-0922-7 Cederholm JME; Froud KE; Wong ACY; Ko M; Ryan AF; Housley GD, 2012, 'Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse', Hearing Research, vol. 292, no. 1-2, pp. 71 - 79, http://dx.doi.org/10.1016/j.heares.2012.08.010 Kim Y; Wong ACY; Power JM; Tadros SF; Klugmann M; Moorhouse AJ; Bertrand PP; Housley GD, 2012, 'Alternative splicing of the TRPC3 ion channel calmodulin/ IP 3 receptor-binding domain in the hindbrain Enhances cation flux', The Journal of Neuroscience, vol. 32, no. 33, pp. 11414 - 11423, http://dx.doi.org/10.1523/JNEUROSCI.6446-11.2012 Vlajkovic SM; Guo CX; Telang R; Wong ACY; Paramananthasivam V; Boison D; Housley GD; Thorne PR, 2011, 'Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss', Experimental Gerontology, vol. 46, no. 11, pp. 905 - 914, http://dx.doi.org/10.1016/j.exger.2011.08.001 Hsieh YSY; Wong CY, 2010, 'The Composition Of Polysaccharides In Primary Walls Of Litchi Chinensis Sonn', Journal of Food Biochemistry, vol. 34, no. 5, pp. 971 - 982, http://dx.doi.org/10.1111/j.1745-4514.2010.00339.x Vlajkovic SM; Lee K-H; Wong ACY; Guo CX; Gupta R; Housley GD; Thorne PR, 2010, 'Adenosine amine congener mitigates noise-induced cochlear injury', Purinergic Signalling, vol. 6, no. 2, pp. 273 - 281, http://dx.doi.org/10.1007/s11302-010-9188-5 Wong ACY; Guo CX; Gupta R; Housley GD; Thorne PR; Vlajkovic SM, 2010, 'Post exposure administration of A1 adenosine receptor agonists attenuates noise-induced hearing loss', Hearing Research, vol. 260, no. 1-2, pp. 81 - 88, http://dx.doi.org/10.1016/j.heares.2009.12.004 Vlajkovic SM; Guo CX; Dharmawardana N; Wong ACY; Boison D; Housley GD; Thorne PR, 2010, 'Role of adenosine kinase in cochlear development and response to noise', Journal of Neuroscience Research, vol. 88, no. 12, pp. 2598 - 2609, http://dx.doi.org/10.1002/jnr.22421