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Drwal MN; Marinello J; Manzo SG; Wakelin LPG; Capranico G; Griffith R, 2014, 'Novel DNA topoisomerase iia inhibitors from combined ligand- and structure- based virtual screening', PLoS One, vol. 9, no. 12, http://dx.doi.org/10.1371/journal.pone.0114904 Chen J; Campbell AP; Urmi KF; Wakelin LPG; Denny WA; Griffith R; Finch AM, 2014, 'Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines', Bioorganic and Medicinal Chemistry, vol. 22, no. 21, pp. 5910 - 5916, http://dx.doi.org/10.1016/j.bmc.2014.09.017 Serobian A; Thomas DS; Ball GE; Denny WA; Wakelin LPG, 2014, 'The solution structure of bis(phenazine-1-carboxamide)-DNA complexes: MLN 944 binding corrected and extended', Biopolymers, vol. 101, no. 11, pp. 1099 - 1113, http://dx.doi.org/10.1002/bip.22513 Chen J; Murad AK; Wakelin LPG; Denny WA; Griffith R; Finch AM, 2013, 'α1-Adrenoceptor and serotonin 5-HT1A receptor affinity of homobivalent 4-aminoquinoline compounds: An investigation of the effect of linker length', Biochemical Pharmacology, vol. 85, no. 10, pp. 1534 - 1541, http://dx.doi.org/10.1016/j.bcp.2013.03.010 Wolf SJ; Huynh T; Bryce NS; Hambley TW; Wakelin LPG; Stewart BW; Catchpoole DR, 2011, 'Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells', BMC Cell Biology, vol. 12, http://dx.doi.org/10.1186/1471-2121-12-36 Drwal MN; Agama K; Wakelin LPG; Pommier Y; Griffith R, 2011, 'Exploring DNA topoisomerase I ligand space in search of novel anticancer agents', PLoS One, vol. 6, no. 9, http://dx.doi.org/10.1371/journal.pone.0025150 He Z; Lai D; Wakelin LPG, 2010, '[Co(III)(cyclen)Cl2]Cl is selectively cytotoxic to human leukaemia cells', European Journal of Pharmacology, vol. 637, no. 1-3, pp. 11 - 15, http://dx.doi.org/10.1016/j.ejphar.2010.03.047 Zihlif M; Catchpoole DR; Stewart BW; Wakelin LPG, 2010, 'Effects of DNA minor groove binding agents on global gene expression', Cancer Genomics and Proteomics, vol. 7, no. 6, pp. 323 - 330 Abdul Majid AMS; Smythe G; Denny WA; Wakelin LPG, 2009, 'Mass spectrometry studies of the binding of the minor groove-directed alkylating agent alkamin to AT-Tract oligonucleotides', Chemical Research in Toxicology, vol. 22, no. 1, pp. 146 - 157, http://dx.doi.org/10.1021/tx800276h Zihlif M; Catchpoole DR; Stewart BW; Wakelin LPG, 2009, 'Effects of DNA threading Bis(9-aminoacridine-4-carboxamides) on global gene expression', Cancer Genomics and Proteomics, vol. 6, no. 6, pp. 317 - 323 Wolf SJ; Wakelin LPG; He Z; Stewart BW; Catchpoole DR, 2009, 'In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines', Cancer Chemotherapy and Pharmacology, vol. 64, no. 6, pp. 1059 - 1069, http://dx.doi.org/10.1007/s00280-009-0962-4 He Z; Bu X; Eleftheriou A; Zihlif M; Qing Z; Stewart BW; Wakelin LPG, 2008, 'DNA threading bis(9-aminoacridine-4-carboxamides): Effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest', Bioorganic and Medicinal Chemistry, vol. 16, no. 8, pp. 4390 - 4400, http://dx.doi.org/10.1016/j.bmc.2008.02.063 Majid AMSA; Smythe G; Denny WA; Wakelin LPG, 2007, 'Structure of the d(CGCGAATTCGCG)2 Complex of the Minor Groove Binding Alkylating Agent Alkamin Studied by Mass Spectrometry', Molecular Pharmacology, vol. 71, no. 4, pp. 1165 - 1178, http://dx.doi.org/10.1124/mol.106.030072 Edwards GL; Black DSC; Deacon GB; Wakelin LPG, 2005, 'Effect of charge and surface area on the cytotoxicity of cationic metallointercalation reagents', Canadian Journal of Chemistry, vol. 83, no. 6-7, pp. 969 - 979, http://dx.doi.org/10.1139/v05-110 Edwards GL; Black DSC; Deacon GB; Wakelin LPG, 2005, 'In vitro and in vivo studies of neutral cyclometallated complexes against murine leukæmias', Canadian Journal of Chemistry, vol. 83, no. 6-7, pp. 980 - 989, http://dx.doi.org/10.1139/v05-109 Adams A; Guss JM; Denny WA; Wakelin LPG, 2004, 'Structure of 9-amino-[N-(2-dimethylamino)propyl]-acridine-4-carboxamide bound to d(CGTACG)2: A comparison of structures of d(CGTACG) 2 complexed with intercalators in the presence of cobalt', Acta Crystallographica Section D: Biological Crystallography, vol. 60, no. 5, pp. 823 - 828, http://dx.doi.org/10.1107/S0907444904003907 Howarth NM; Wakelin LPG; Walker DM, 2003, 'Synthesis of the four diastereoisomers of 3-thymine-1-(tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid', Tetrahedron Letters, vol. 44, no. 4, pp. 695 - 698, http://dx.doi.org/10.1016/S0040-4039(02)02696-5 Howarth NM; Wakelin LPG; Walker DM, 2003, 'α-cycloPNA: 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid', Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication, vol. 22, no. 5-8, pp. 1351 - 1353, http://dx.doi.org/10.1081/NCN-120022963 Baguley BC; Wakelin LPG; Jacintho JD; Kovacic P, 2003, 'Mechanisms of action of DNA intercalating acridine-based drugs: How important are contributions from electron transfer and oxidative stress?', Current Medicinal Chemistry, vol. 10, no. 24, pp. 2643 - 2649, http://dx.doi.org/10.2174/0929867033456332 Wakelin LPG; Bu X; Eleftheriou A; Parmar A; Hayek C; Stewart BW, 2003, 'Bisintercalating Threading Diacridines: Relationships between DNA Binding, Cytotoxicity, and Cell Cycle Arrest', Journal of Medicinal Chemistry, vol. 46, no. 26, pp. 5790 - 5802, http://dx.doi.org/10.1021/jm030253d