个人简介

Education BSc (Hons Class 1), University of Wollongong (1999) PhD, University of Wollongong (2004) Professional Experience Lecturer, Department of Biomedical Science, University of Wollongong, Australia (2004) Visiting Research Fellow, AstraZeneca R&D, Mölndal, Sweden (2006) Visiting Research Fellow, Beth Israel Deaconess Medical Center, Boston, USA (2007) Research Officer/Senior Research Officer/Group Leader, Garvan Institute of Medical Research, Sydney, Australia (2005-2012) Honours and Awards University Medal, Faculty of Health and Behavioural Science, University of Wollongong (2000) Australian Postgraduate Award (2000-2003) NHMRC Peter Doherty Postdoctoral Fellowship (2005-2007) Scientific Travel Grant USA, Australian Academy of Science (2007) NHMRC Career Development Award (2008-2011) ARC Future Fellowship (2012-2016) Editorial advisory board member for Biochemical Journal

研究领域

Cell Metabolism

Mitochondria are the primary site of energy production within cells. Mitochondrial dysfunction has been linked with a number of inherited and acquired human diseases and has also been implicated in the aging process. A major focus of our studies is to examine how alterations in mitochondrial function in different tissues influences insulin action in obesity and type 2 diabetes. We are interested in how certain drugs and different types of dietary fats (e.g. medium chain fatty acids) affect mitochondrial content and metabolism. We are also examining the role of post-translational modification in the function of mitochondrial proteins. Another area of research is the importance of alterations in mitochondrial bioenergetics in certain types of cancers.

近期论文

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Parker AL; Turner N; McCarroll JA; Kavallaris M, 2016, 'βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells', Carcinogenesis, vol. 37, no. 8, pp. 787 - 798, http://dx.doi.org/10.1093/carcin/bgw058 Quek LE; Liu M; Joshi S; Turner N, 2016, 'Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment.', Cancer and Metabolism, vol. 4, pp. 13, http://dx.doi.org/10.1186/s40170-016-0153-9 Osborne B; Bentley NL; Montgomery MK; Turner N, 2016, 'The role of mitochondrial sirtuins in health and disease', Free Radical Biology and Medicine, http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.197 Couttas TA; Kain N; Suchowerska AK; Quek LE; Turner N; Fath T; Garner B; Don AS, 2016, 'Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease', Neurobiology of Aging, vol. 43, pp. 89 - 100, http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.027 Turner N; Zeng XY; Osborne B; Rogers S; Ye JM, 2016, 'Repurposing Drugs to Target the Diabetes Epidemic', Trends in Pharmacological Sciences, vol. 37, no. 5, pp. 379 - 389, http://dx.doi.org/10.1016/j.tips.2016.01.007 Brandon AE; Stuart E; Leslie SJ; Hoehn KL; James DE; Kraegen EW; Turner N; Cooney GJ, 2016, 'Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice.', Journal of Endocrinology, vol. 228, no. 3, pp. 127 - 134, http://dx.doi.org/10.1530/JOE-15-0444 Le Couteur DG; Tay SS; Solon-Biet S; Bertolino P; McMahon AC; Cogger VC; Colakoglu F; Warren A; Holmes AJ; Pichaud N; Horan M; Correa C; Melvin RG; Turner N; O Ballard JW; Ruohonen K; Raubenheimer D; Simpson SJ, 2015, 'The influence of macronutrients on splanchnic and hepatic lymphocytes in aging mice', Journal of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 70, no. 12, pp. 1499 - 1507, http://dx.doi.org/10.1093/gerona/glu196 Montgomery MK; Fiveash CE; Braude JP; Osborne B; Brown SHJ; Mitchell TW; Turner N, 2015, 'Disparate metabolic response to fructose feeding between different mouse strains', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep18474 Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, no. 2, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602 Joshi S; Liu M; Turner N, 2015, 'Diabetes and its link with cancer: Providing the fuel and spark to launch an aggressive growth regime', BioMed Research International, vol. 2015, http://dx.doi.org/10.1155/2015/390863 Brandon AE; Tid-Ang J; Wright LE; Stuart E; Suryana E; Bentley N; Turner N; Cooney GJ; Ruderman NB; Kraegen EW, 2015, 'Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance', PLoS One, vol. 10, no. 3, http://dx.doi.org/10.1371/journal.pone.0121959 Montgomery MK; Turner N, 2015, 'Mitochondrial dysfunction and insulin resistance: an update.', Endocrine Connections, vol. 4, no. 1, pp. R1 - R15, http://dx.doi.org/10.1530/EC-14-0092 Turner N; Robker RL, 2014, 'Developmental programming of obesity and insulin resistance: Does mitochondrial dysfunction in oocytes play a role?', Molecular Human Reproduction, vol. 21, no. 1, pp. 23 - 30, http://dx.doi.org/10.1093/molehr/gau042 Ericsson A; Turner N; Hansson GI; Wallenius K; Oakes ND, 2014, 'Pharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat', PLoS One, vol. 9, no. 12, http://dx.doi.org/10.1371/journal.pone.0113328 Mokbel N; Hoffman NJ; Girgis CM; Small L; Turner N; Daly RJ; Cooney GJ; Holt LJ, 2014, 'Grb10 Deletion Enhances Muscle Cell Proliferation, Differentiation and GLUT4 Plasma Membrane Translocation', Journal of Cellular Physiology, vol. 229, no. 11, pp. 1753 - 1764, http://dx.doi.org/10.1002/jcp.24628 Liu M; Montgomery MK; Fiveash CE; Osborne B; Cooney GJ; Bell-Anderson K; Turner N, 2014, 'PPARα -independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis', Scientific Reports, vol. 4, http://dx.doi.org/10.1038/srep05538 Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, vol. 19, no. 3, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009 Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, vol. 3, no. 4, pp. 465 - 473, http://dx.doi.org/10.1016/j.molmet.2014.02.005 Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation', Molecular Metabolism, vol. 3, no. 4, pp. 419 - 431, http://dx.doi.org/10.1016/j.molmet.2014.02.004 Sullivan K; El-hoss J; Quinlan KGR; Deo N; Garton F; Seto JTC; Gdalevitch M; Turner N; Cooney GJ; Kolanczyk M; North KN; Little DG; Schindeler A, 2014, 'NF1 is a critical regulator of muscle development and metabolism', Human Molecular Genetics, vol. 23, no. 5, pp. 1250 - 1259, http://dx.doi.org/10.1093/hmg/ddt515