研究领域

Autoimmunity, Rheumatology and Arthritis, Cellular Immunology

The main focus of this research group is to study the functional properties and the regulation of a new class of immuno-regulatory receptors termed as Leukocyte immunoglobulin-like receptors (LILRs) (Fig 1) and to define their functional role in determining the fine balance between immune activation and inhibition. The clinical consequence of the functional dysregulation of these receptors and their ligands in autoimmune diseases are the subjects of our continued studies.

近期论文

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Pollock AH; Tedla N; Hancock SE; Cornely R; Mitchell TW; Yang Z; Kockx M; Parton RG; Rossy J; Gaus K, 2016, 'Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr-/- mice', Journal of Immunology, vol. 196, no. 10, pp. 3993 - 4002, http://dx.doi.org/10.4049/jimmunol.1501261 An H; Brettle M; Lee T; Heng B; Lim CK; Guillemin GJ; Lord MS; Klotzsch E; Geczy CL; Bryant K; Fath T; Tedla N, 2016, 'Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66', Journal of Cell Science, vol. 129, no. 6, pp. 1198 - 1209, http://dx.doi.org/10.1242/jcs.182006 An H; Lim C; Guillemin GJ; Vollmer-Conna U; Rawlinson W; Bryant K; Tedla N, 2016, 'Serum Leukocyte immunoglobulin-like receptor A3 (LILRA3) is increased in patients with multiple sclerosis and is a strong independent indicator of disease severity; 6.7kbp LILRA3 gene deletion is not', PLoS One, vol. 11, no. 2, http://dx.doi.org/10.1371/journal.pone.0149200 Fahmy RG; Waldman A; Zhang G; Mitchell A; Tedla N; Cai H; Geczy CR; Chesterman CN; Perry M; Khachigian LM, 2015, 'Erratum: Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun(Nat.Biotechnol.(2006) 24(856-863))', Nature Biotechnology, vol. 33, no. 8, pp. 882, http://dx.doi.org/10.1038/nbt0815-882c Kane BA; Bryant KJ; McNeil HP; Tedla NT, 2014, 'Termination of immune activation: An essential component of healthy host immune responses', Journal of Innate Immunity, vol. 6, no. 6, pp. 727 - 738, http://dx.doi.org/10.1159/000363449 Hiroshima Y; Hsu K; Tedla N; Chung YM; Chow S; Herbert C; Geczy CL, 2014, 'S100A8 induces IL-10 and protects against acute lung injury', Journal of Immunology, vol. 192, no. 6, pp. 2800 - 2811, http://dx.doi.org/10.4049/jimmunol.1302556 Herbert C; Shadie AM; Bunting MM; Tedla N; Garthwaite L; Freeman A; Yoo H; Park SH; Kumar RK, 2014, 'Anti-inflammatory and anti-remodelling effects of ISU201, a modified form of the extracellular domain of human BST2, in experimental models of asthma: Association with inhibition of histone acetylatio', PLoS One, vol. 9, no. 3, http://dx.doi.org/10.1371/journal.pone.0090436 Lee THY; Mitchell A; Lau SL; An H; Rajeaskariah P; Wasinger V; Raftery M; Bryant K; Tedla N, 2013, 'Glycosylation in a mammalian expression system is critical for the production of functionally active leukocyte immunoglobulin-like receptor A3 protein', Journal of Biological Chemistry, vol. 288, no. 46, pp. 32873 - 32885, http://dx.doi.org/10.1074/jbc.M113.478578 Chung YM; Goyette J; Tedla N; Hsu K; Geczy CL, 2013, 'S100A12 Suppresses Pro-inflammatory, but Not Pro-Thrombotic Functions of Serum Amyloid A', PLoS One, vol. 8, no. 4, http://dx.doi.org/10.1371/journal.pone.0062372 Bunting MM; Shadie AM; Flesher RP; Nikiforova V; Garthwaite L; Tedla N; Herbert C; Kumar RK, 2013, 'Interleukin-33 drives activation of alveolar macrophages and airway inflammation in a mouse model of acute exacerbation of chronic asthma', BioMed Research International, vol. 2013, http://dx.doi.org/10.1155/2013/250938 Tong D; Chui J; Tedla N; O'Neill S, 2012, 'LEUKOCYTE IMMUNOLOGLOBULIN-LIKE RECEPTORS EXPRESSION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS', Internal Medicine Journal, vol. 42, pp. 20 - 21, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000302622800070&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Lu HK; Mitchell A; Endoh Y; Hampartzoumian T; Huynh O; Borges L; Geczy C; Bryant K; Tedla N, 2012, 'LILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes', PLoS One, vol. 7, no. 3, http://dx.doi.org/10.1371/journal.pone.0033478 Herbert C; Scott MM; Keogh R; Siegle JS; Yuan K; Tedla N; Foster PS; Kumar RK, 2010, 'Alternatively Activated Alveolar Macrophages Stimulate Th2 Cytokine Production by Primed CD4(+) T Cells in a Model of an Acute Exacerbation of Asthma', American Journal of Respiratory and Critical Care Medicine, vol. 181, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208771003155&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a An H; Chandra V; Piraino B; Borges L; Geczy C; McNeil HP; Bryant K; Tedla N, 2010, 'Soluble LILRA3, a potential natural antiinflammatory protein, is increased in patients with rheumatoid arthritis and is tightly regulated by interleukin 10, tumor necrosis factor-α, and interferon-γ', Journal of Rheumatology, vol. 37, no. 8, pp. 1596 - 1606, http://dx.doi.org/10.3899/jrheum.091119 Herbert C; Scruton K; Hsu K; Siegle JS; Hansbro N; Foster PS; Tedla N; Kumar RK, 2009, 'Enhanced Expression of Cytokines by Pulmonary T-Cells and Macrophages in a Model of Exacerbations of Chronic Asthma.', American Journal of Respiratory and Critical Care Medicine, vol. 179, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208733103592&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Lu HK; Rentero C; Raftery MJ; Borges L; Bryant K; Tedla N, 2009, 'Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcγRI-mediated monocyte activation via dephosphorylation of multiple kinases', Journal of Biological Chemistry, vol. 284, no. 50, pp. 34839 - 34848, http://dx.doi.org/10.1074/jbc.M109.035683 Lee GS; Grimm MC; Borges L; Tedla N, 2008, 'Leukocyte immunoglobulin-like receptors in the human colon', Gastroenterology, vol. 134, no. 4, pp. A511 - A511, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000255101503532&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Rentero C; Magenau A; Williamson D; Tedla N; Gaus K, 2008, 'Membrane domains as signaling centers in macrophages and T-cells: From concepts to experiments', Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, vol. 8, no. 4, pp. 336 - 348, http://dx.doi.org/10.2174/187152208787169152 Mitchell A; Rentero C; Endoh Y; Hsu K; Gaus K; Geczy C; McNeil HP; Borges L; Tedla N, 2008, 'LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-alphα, IL-10 and IFN-γ', European Journal of Immunology, vol. 38, no. 12, pp. 3459 - 3473, http://dx.doi.org/10.1002/eji.200838415