研究领域

Pathology, Infectious Diseases, Virology

My research focus is on laboratory contributions for control of diseases of public health importance, with special emphasis on diseases caused by the ptahogenic Neisseria and antimicrobial resistance (AMR). These interests intersect most obviously in gonococcal (GC) disease. Achievements include the formation of the Australian Gonococcal Surveillance Program (AGSP) in 1979 and in 1994 its meningococcal (MC) equivalent (AMSP), now combined and maintained as the National Neisseria Network (NNN) which I co-ordinate. This successful model was used to establish a similar WHO Gonococcal Antimicrobial Surveillance Program (GASP) in its (separate) Western Pacific and South East Asian regions with more than 20 countries participating. These networks provide information for action via annual or quarterly data and analytical reports. N. gonorrhoeae is the most problematic STI in terms of AMR in Australia and globally. Other related outcomes nationally and internationally include optimised laboratory diagnostic procedures (including molecular diagnostics) and formulation of national diagnostic guidelines; applications of pathogen typing methods; and optimisation of programmatic treatments for disease control. Antimicrobial resistance [AMR] is increasing and this decreases treatment options. Surveillance of AMR is needed to determine programmatic as well as individual treatments but must be properly conducted to provide valid data. We conduct, in conjunction with the World Health Organization, comprehensive continuous and active surveillance of AMR in the pathogenc Neisseria (gonococci and meningococci) and link this to disease surveillance and control in Australia and the Western Pacific.

近期论文

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Goire N; Freeman K; Tapsall JW; Lambert SB; Nissen MD; Sloots TP; Whiley DM, 2011, 'Enhancing gonococcal antimicrobial resistance surveillance: A real-time PCR assay for detection of penicillinase-producing Neisseria gonorrhoeae by use of noncultured clinical samples', Journal of Clinical Microbiology, vol. 49, no. 2, pp. 513 - 518, http://dx.doi.org/10.1128/JCM.02024-10 Whiley DM; Goire N; Lambert SB; Nissen MD; Sloots TP; Tapsall JW, 2011, 'Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is spread internationally by genetically distinct gonococcal populations', Journal of Antimicrobial Chemotherapy, vol. 66, no. 5, pp. 1186 - 1187, http://dx.doi.org/10.1093/jac/dkr052 Whiley DM; Goire N; Lambert SB; Ray S; Limnios EA; Nissen MD; Sloots TP; Tapsall JW, 2010, 'Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillin-binding protein 2', Journal of Antimicrobial Chemotherapy, vol. 65, no. 8, pp. 1615 - 1618, http://dx.doi.org/10.1093/jac/dkq187 Whiley DM; Jacobsson S; Tapsall JW; Nissen MD; Sloots TP; Unemo M, 2010, 'Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains', Journal of Antimicrobial Chemotherapy, vol. 65, no. 12, pp. 2543 - 2547, http://dx.doi.org/10.1093/jac/dkq377 Tapsall J; Read P; Carmody C; Bourne C; Ray S; Limnios A; Sloots T; Whiley D, 2009, 'Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods.', Journal of Medical Microbiology, vol. 58, no. Pt 5, pp. 683 - 687, http://dx.doi.org/10.1099/jmm.0.007641-0 Tapsall JW, 2009, 'Neisseria gonorrhoeae and emerging resistance to extended spectrum cephalosporins', Current Opinion in Infectious Diseases, vol. 22, no. 1, pp. 87 - 91, http://dx.doi.org/10.1097/QCO.0b013e328320a836 Vernel-Pauillac F; Hogan TR; Tapsall JW; Goarant C, 2009, 'Quinolone resistance in reisseria gonorrhoeae: Rapid genotyping of quinolone resistance-determining regions in gyrA and parC genes by melting curve analysis predicts susceptibility', Antimicrobial Agents and Chemotherapy, vol. 53, no. 3, pp. 1264 - 1267, http://dx.doi.org/10.1128/AAC.01104-08 Tapsall JW, 2009, 'Implications of current recommendations for third-generation cephalosporin use in the WHO Western Pacific Region following the emergence of multiresistant gonococci', Sexually Transmitted Infections, vol. 85, no. 4, pp. 256 - 258, http://dx.doi.org/10.1136/sti.2008.035337 Kugelman G; Tapsall JW; Goire N; Syrmis MW; Limnios A; Lambert SB; Nissen MD; Sloots TP; Whiley DM, 2009, 'Simple, rapid, and inexpensive detection of Neisseria gonorrhoeae resistance mechanisms using heat-denatured isolates and SYBR green-based real-time PCR', Antimicrobial Agents and Chemotherapy, vol. 53, no. 10, pp. 4211 - 4216, http://dx.doi.org/10.1128/AAC.00385-09 Mak JK; Kim MJ; Pham J; Tapsall J; White PA, 2009, 'Antibiotic resistance determinants in nosocomial strains of multidrug-resistant Acinetobacter baumannii', Journal of Antimicrobial Chemotherapy, vol. 63, no. 1, pp. 47 - 54, http://dx.doi.org/10.1093/jac/dkn454 Unemo M; Fasth O; Fredlund H; Limnios A; Tapsall JW, 2009, 'Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance su', Journal of Antimicrobial Chemotherapy, vol. 63, pp. 1142 - 1151 Tapsall JW, 2009, 'Multidrug-resistant Neisseria gonorrhoeae', CMAJ, vol. 180, pp. 268 - 269 Tapsall JW; Limnios EA; Murphy D, 2008, 'Analysis of trends in antimicrobial resistance in Neisseria gonorrhoeae isolated in Australia, 1997-2006', Journal of Antimicrobial Chemotherapy, vol. 61, no. 1, pp. 150 - 155, http://dx.doi.org/10.1093/jac/dkm434 Shultz TR; White PA; Tapsall JW, 2005, 'In vitro assessment of the further potential for development of fluoroquinolone resistance in Neisseria meningitidis', Antimicrobial Agents and Chemotherapy, vol. 49, no. 5, pp. 1753 - 1760, http://dx.doi.org/10.1128/AAC.49.5.1753-1760.2005 McIver CJ; Hogan TR; White PA; Tapsall JW, 2004, 'Patterns of quinolone susceptibility in Campylobacter jejuni associated with different gyrA mutations', Pathology, vol. 36, no. 2, pp. 166 - 169, http://dx.doi.org/10.1080/00313020410001672019 Kotiw M; Zhang GW; Daggard G; Reiss-Levy E; Tapsall JW; Numa A, 2003, 'Late-onset and recurrent neonatal Group B streptococcal disease associated with breast-milk transmission', Pediatric and Developmental Pathology, vol. 6, no. 3, pp. 251 - 256, http://dx.doi.org/10.1007/s10024-001-0276-y Shultz TR; Tapsall JW; White PA; Ryan CS; Lyras D; Rood JI; Binotto E; Richardson CJL, 2003, 'Chloramphenicol-resistant Neisseria meningitidis containing catP isolated in Australia', Journal of Antimicrobial Chemotherapy, vol. 52, no. 5, pp. 856 - 859, http://dx.doi.org/10.1093/jac/dkg452 Poulos RG; Smedley EJ; Ferson MJ; Bolisetty S; Tapsall JW, 2002, 'Refining the public health response to primary meningococcal conjunctivitis.', Communicable Diseases Intelligence Quarterly Report, vol. 26, no. 4, pp. 592 - 595 Tapsall JW, 2000, 'The biology of Neisseria gonorrhoeae: A model of adaptation and survival', Venereology : official publication of the National Venereology Council of Australia, vol. 13, no. 2, pp. 63 - 69 Shultz TR; Tapsall JW; White PA; Newton AJ, 2000, 'An invasive isolate of Neisseria meningitidis showing decreased susceptibility to quinolones [1]', Antimicrobial Agents and Chemotherapy, vol. 44, no. 4, pp. 1116, http://dx.doi.org/10.1128/AAC.44.4.1116-1116.2000