个人简介

Roland Stocker is an international leader in the field of redox biology who through his career has made seminal contributions and shifted paradigms in the field of oxidative processes and antioxidants in cardiovascular disease. His research includes the discovery of beneficial antioxidant activities of the bile pigment bilirubin; identification of the reduced form of coenzyme Q10 as an important antioxidant in circulating lipoproteins; key discoveries understanding the molecular action of vitamin E during lipoprotein oxidation and delineating contributions of the latter to atherogenesis; pioneering work in heme oxygenase-1 and indoleamine 2,3-dioxygenase.

研究领域

Roland has been recognised as a “Redox Pioneer” by the journal Antiox Redox Signal for his contributions to the field of redox biology. His areas of expertise include low-molecular weight non-proteinaceous antioxidants (bile pigments, coenzyme Q10, vitamins C and E, tryptophan metabolites, flavonoids); probucol; oxidative modifications of lipoproteins (LDL, HDL) and their roles in the pathogenesis of atherosclerosis; the involvement of myeloperoxidase to endothelial dysfunction and atherosclerosis; the role of heme oxygenase-1 in vascular health and disease; the contributions of indoleamine 2,3-dioxygenase to antioxidant defence and the control of vascular tone/blood pressure; and animal models of atherosclerosis and related vascular diseases.

Our research focuses on the hardening of blood vessels (a process also called atherosclerosis) that is the single major cause of heart attacks and stroke, and hence death, in Australia. We study the contribution of oxidative processes to atherosclerosis, and how the disease can be inhibited. We have identified a protein, the up-regulation of which affects many biological processes, resulting in the inhibition of disease in several animal models. We are now studying how a change in a single protein can have such multiple biological effects, with a focus on vascular health and disease. We also have discovered a novel protein that regulates the tone of blood vessels and blood pressure in conditions of inflammation, and are now seeking to better understand the underlying principles of this action. Finally, we have established a new Core Facility to assess oxidative stress in vitro and in vivo, and we are developing new methods and tools to apply this to cardiovascular and other research.

近期论文

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Shi H; O Reilly VC; Moreau JLM; Bewes TR; Yam MX; Chapman BE; Grieve SM; Stocker R; Graham RM; Chapman G; Sparrow DB; Dunwoodie SL, 2016, 'Gestational stress induces the unfolded protein response, resulting in heart defects', Development (Cambridge), vol. 143, no. 14, pp. 2561 - 2572, http://dx.doi.org/10.1242/dev.136820 Too LK; Li KM; Suarna C; Maghzal GJ; Stocker R; McGregor IS; Hunt NH, 2016, 'Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function', Behavioural Brain Research, vol. 312, pp. 102 - 117, http://dx.doi.org/10.1016/j.bbr.2016.06.018 Lam MA; Maghzal GJ; Khademi M; Piehl F; Ratzer R; Romme Christensen J; Sellebjerg FT; Olsson T; Stocker R, 2016, 'Absence of systemic oxidative stress and increased CSF prostaglandin F2α in progressive MS.', Neurology: Neuroimmunology and Neuroinflammation, vol. 3, no. 4, pp. e256, http://dx.doi.org/10.1212/NXI.0000000000000256 Stocker R, 2016, 'Antioxidant defenses in human blood plasma and extra-cellular fluids', Archives of Biochemistry and Biophysics, vol. 595, pp. 136 - 139, http://dx.doi.org/10.1016/j.abb.2015.11.021 Seredenina T; Nayernia Z; Sorce S; Maghzal GJ; Filippova A; Ling SC; Basset O; Plastre O; Daali Y; Rushing EJ; Giordana MT; Cleveland DW; Aguzzi A; Stocker R; Krause KH; Jaquet V, 2016, 'Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis', Free Radical Biology and Medicine, vol. 97, pp. 95 - 108, http://dx.doi.org/10.1016/j.freeradbiomed.2016.05.016 Talib J; Maghzal GJ; Cheng D; Stocker R, 2016, 'Detailed protocol to assess in vivo and ex vivo myeloperoxidase activity in mouse models of vascular inflammation and disease using hydroethidine', Free Radical Biology and Medicine, vol. 97, pp. 124 - 135, http://dx.doi.org/10.1016/j.freeradbiomed.2016.05.004 Schmidt HHHW; Stocker R; Paulsen G; Ghezzi P; Riley D; Daiber A; Cuadrado A, 2016, 'Response to I. Batinic-Haberle et al.', Antioxidants and Redox Signaling, vol. 24, no. 9, pp. 525 - 526, http://dx.doi.org/10.1089/ars.2016.29029.hhs Cullen JK; Murad NA; Yeo A; McKenzie M; Ward M; Chong KL; Schieber NL; Parton RG; Lim YC; Wolvetang E; Maghzal GJ; Stocker R; Lavin MF, 2016, 'AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation', PLoS One, vol. 11, no. 2, http://dx.doi.org/10.1371/journal.pone.0148213 Schmidt HHHW; Stocker R; Vollbracht C; Paulsen G; Riley D; Daiber A; Cuadrado A, 2015, 'Antioxidants in Translational Medicine', Antioxidants and Redox Signaling, vol. 23, no. 14, pp. 1130 - 1143, http://dx.doi.org/10.1089/ars.2015.6393 Casas AI; Dao VTV; Daiber A; Maghzal GJ; Di Lisa F; Kaludercic N; Leach S; Cuadrado A; Jaquet V; Seredenina T; Krause KH; López MG; Stocker R; Ghezzi P; Schmidt HHHW, 2015, 'Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications', Antioxidants and Redox Signaling, vol. 23, no. 14, pp. 1171 - 1185, http://dx.doi.org/10.1089/ars.2015.6433 Dao VTV; Casas AI; Maghzal GJ; Seredenina T; Kaludercic N; Robledinos-Anton N; Di Lisa F; Stocker R; Ghezzi P; Jaquet V; Cuadrado A; Schmidt HHHW, 2015, 'Pharmacology and Clinical Drug Candidates in Redox Medicine', Antioxidants and Redox Signaling, vol. 23, no. 14, pp. 1113 - 1129, http://dx.doi.org/10.1089/ars.2015.6430 Frijhoff J; Winyard PG; Zarkovic N; Davies SS; Stocker R; Cheng D; Knight AR; Taylor EL; Oettrich J; Ruskovska T; Gasparovic AC; Cuadrado A; Weber D; Poulsen HE; Grune T; Schmidt HHHW; Ghezzi P, 2015, 'Clinical Relevance of Biomarkers of Oxidative Stress', Antioxidants and Redox Signaling, vol. 23, no. 14, pp. 1144 - 1170, http://dx.doi.org/10.1089/ars.2015.6317 De Blasio MJ; Huynh K; Qin C; Rosli S; Kiriazis H; Ayer A; Cemerlang N; Stocker R; Du XJ; McMullen JR; Ritchie RH, 2015, 'Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling', Free Radical Biology and Medicine, vol. 87, pp. 137 - 147, http://dx.doi.org/10.1016/j.freeradbiomed.2015.04.028 Ayer A; Macdonald P; Stocker R, 2015, 'CoQ10 Function and Role in Heart Failure and Ischemic Heart Disease', Annual Review of Nutrition, vol. 35, no. 1, pp. 175 - 213, http://dx.doi.org/10.1146/annurev-nutr-071714-034258 Fraser ST; Midwinter RG; Coupland LA; Kong S; Berger BS; Yeo JH; Andrade OC; Cromer D; Suarna C; Lam M; Maghzal GJ; Chong BH; Parish CR; Stocker R, 2015, 'Heme oxygenase-1 deficiency alters erythroblastic Island formation, steady-state erythropoiesis and red blood cell lifespan in mice', Haematologica: the hematology journal, vol. 100, no. 5, pp. 601 - 610, http://dx.doi.org/10.3324/haematol.2014.116368 Vallelian F; Deuel JW; Opitz L; Schaer CA; Puglia M; Lönn M; Engelsberger W; Schauer S; Karnaukhova E; Spahn DR; Stocker R; Buehler PW; Schaer DJ, 2015, 'Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress', Cell Death and Differentiation, vol. 22, no. 4, pp. 597 - 611, http://dx.doi.org/10.1038/cdd.2014.154 Maghzal GJ; Winter S; Wurzer B; Chong BH; Holmdahl R; Stocker R, 2014, 'Tryptophan catabolism is unaffected in chronic granulomatous disease', Nature, vol. 514, no. 7523, pp. E16 - E17, http://dx.doi.org/10.1038/nature13844 Khaw LT; Ball HJ; Mitchell AJ; Grau GE; Stocker R; Golenser J; Hunt NH, 2014, 'Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors', Experimental Parasitology, vol. 145, no. 1, pp. 34 - 41, http://dx.doi.org/10.1016/j.exppara.2014.07.002 O'Hare Doig RL; Bartlett CA; Maghzal GJ; Lam M; Archer M; Stocker R; Fitzgerald M, 2014, 'Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration', Experimental Neurology, vol. 261, pp. 136 - 146, http://dx.doi.org/10.1016/j.expneurol.2014.06.007 Shen Y; Croft KD; Hodgson JM; Kyle R; Lee ILE; Wang Y; Stocker R; Ward NC, 2014, 'Erratum: Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK (Biochem. Pharmacol. (2012):84:1036-1044)', Biochemical Pharmacology, vol. 88, no. 2, pp. 266, http://dx.doi.org/10.1016/j.bcp.2013.08.021