个人简介
Justine Stehn received her PhD from the Garvan Institute of Medical Research in 2000. She was awarded a prestigious National Health and Medical Research Council (NHMRC), CJ Martin Fellowship to support her post doctoral positions at Harvard University and the Centre for Cancer Research at the Massachusetts Institute of Technology (MIT), Boston, USA. The fellowship also supported two years further research in Australia and upon her return in 2003 Dr Stehn took up a position in the Oncology Research Unit at the Children’s Hospital at Westmead. Her main research focus for the past 9 years has been investigating the biological function of the actin cytoskeleton in cancer cells. The Oncology Research Unit relocated to the University of New South Wales in 2008 and Dr Stehn is currently the group leader of the Drug Development Project in the Cellular and Genetic Medicine Unit in the School of Medical Sciences. In 2009 Dr Stehn was awarded an Oncology Children’s Foundation Research Fellowship supported by The Kids Cancer Project.
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Glass JJ; Phillips PA; Gunning PW; Stehn JR, 2015, 'Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells', BMC Cancer, http://dx.doi.org/10.1186/s12885-015-1741-8
Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, vol. 26, no. 13, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453
Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T; Schevzov G; Gunning PW, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS One, vol. 10, no. 5, http://dx.doi.org/10.1371/journal.pone.0126214
Vindin H; Bischof L; Gunning P; Stehn J, 2014, 'Validation of an algorithm to quantify changes in actin cytoskeletal organization', Journal of Biomolecular Screening, vol. 19, no. 3, pp. 354 - 368, http://dx.doi.org/10.1177/1087057113503494
Desouza M; Nguyen M; Gunning PW; Stehn JR, 2013, 'Targeting the actin cytoskeleton of neuroblastoma: Elucidating the mechanism by which a novel class of anti-cancer compounds induces tumor cell death.', Molecular Cancer Therapeutics, vol. 12, no. 11, http://dx.doi.org/10.1158/1535-7163.TARG-13-C208
Wang B; Schevzov G; Coombes J; Hook J; Kee A; Lucas C; Stehn J; Sequeira V; Seger R; Hardeman E; Gunning P, 2013, 'Regulation of cell proliferation mediated by the actin filament regulator Tropomyosin 5NM1', Molecular Biology of the Cell, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PRBB; Sequeira VB; Butler TL; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer SJ; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning PW, 2013, 'A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells', Cancer Research, vol. 73, no. 16, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501
Desouza M; Gunning PW; Stehn JR, 2012, 'The actin cytoskeleton as a sensor and mediator of apoptosis.', Bioarchitecture, vol. 2, no. 3, pp. 75 - 87, http://dx.doi.org/10.4161/bioa.20975
Schevzov G; Coombes J; Hook J; Wang B; Kee A; Lucas C; Szokolai R; Sequeira V; Stehn J; Musgrove E; Hardeman E; Gunning P, 2012, 'Regulation of cell proliferation mediated by the actin filament stabilizing protein, Tropomyosin 5NM1.', Molecular Biology of the Cell, vol. 23, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348601219&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Creed SJ; Desouza M; Bamburg JR; Gunning P; Stehn J, 2011, 'Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments', Experimental Cell Research, vol. 317, no. 3, pp. 249 - 261, http://dx.doi.org/10.1016/j.yexcr.2010.10.019
Bach CTT; Creed S; Zhong J; Mahmassani M; Schevzov G; Stehn J; Cowell LN; Naumanen P; Lappalainen P; Gunning PW; O'Neill GM, 2009, 'Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and direction', Molecular and Cellular Biology, vol. 29, no. 6, pp. 1506 - 1514, http://dx.doi.org/10.1128/MCB.00857-08
Bonello TT; Stehn JR; Gunning PW, 2009, 'New approaches to targeting the actin cytoskeleton for chemotherapy', Future Medicinal Chemistry, vol. 1, no. 7, pp. 1311 - 1331, http://dx.doi.org/10.4155/fmc.09.99
O'Neill GM; Stehn J; Gunning PW, 2008, 'Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton', Seminars in Cancer Biology, vol. 18, no. 1, pp. 35 - 44, http://dx.doi.org/10.1016/j.semcancer.2007.08.004
Creed SJ; Bryce N; Naumanen P; Weinberger R; Lappalainen P; Stehn J; Gunning P, 2008, 'Tropomyosin isoforms define distinct microfilament populations with different drug susceptibility', European Journal of Cell Biology, vol. 87, no. 8-9, pp. 709 - 720, http://dx.doi.org/10.1016/j.ejcb.2008.03.004
Stehn JR; Schevzov G; O'Neill GM; Gunning PW, 2006, 'Specialisation of the tropomyosin composition of actin filaments provides new potential targets for chemotherapy', Current Cancer Drug Targets, vol. 6, no. 3, pp. 245 - 256, http://dx.doi.org/10.2174/156800906776842948
Ludowyke RI; Elgundi Z; Kranenburg T; Stehn JR; Schmitz-Peiffer C; Hughes WE; Biden TJ, 2006, 'Phosphorylation of nonmuscle myosin heavy chain IIA on Ser1917 is mediated by protein kinase CβII and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells', Journal of Immunology, vol. 177, no. 3, pp. 1492 - 1499
Nguyen A; Rothman DM; Stehn J; Imperiali B; Yaffe MB, 2004, 'Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function', Nature Biotechnology, vol. 22, no. 8, pp. 993 - 1000, http://dx.doi.org/10.1038/nbt997
Vázquez ME; Nitz M; Stehn J; Yaffe MB; Imperiali B, 2003, 'Fluorescent caged phosphoserine peptides as probes to investigate phosphorylation-dependent protein associations', Journal of the American Chemical Society, vol. 125, no. 34, pp. 10150 - 10151, http://dx.doi.org/10.1021/ja0351847
Brunet A; Kanai F; Stehn J; Xu J; Sarbassova D; Frangioni JV; Dalal SN; Decaprio JA; Greenberg ME; Yaffe MB, 2002, '14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport', The Journal of Cell Biology, vol. 156, no. 5, pp. 817 - 828, http://dx.doi.org/10.1083/jcb.200112059
Johnson BA; Stehn JR; Yaffe MB; Keith Blackwell T, 2002, 'Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms', Journal of Biological Chemistry, vol. 277, no. 20, pp. 18029 - 18036, http://dx.doi.org/10.1074/jbc.M110465200
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