研究领域

Neuroscience, Ageing, Inflammation, Proteomics, Ageing

Neurodegenerative diseases of aging such as Alzheimer's Disease are associated with oxidative and free radical-induced damage to DNA, proteins, and energy metabolism in the CNS, Of particular interest are diagnostic markers of this damage and the role of anti-oxidants, radical scavengers and metal chelators in attenuating the damage. Collaborative work with neuroscientists at St Vincent's and Prince of Wales Hospitals and Monash University is investigating Alzheimer's and other dementing diseases, Other collaborations with neuroscientists in the UK is investigating malaria-induced brain dysfunction.

近期论文

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Braidy N; Poljak A; Grant R; Jayasena T; Mansour H; Chan-Ling T; Smythe G; Sachdev P; Guillemin GJ, 2015, 'Differential expression of sirtuins in the aging rat brain', Frontiers in Cellular Neuroscience, vol. 9, no. MAY, http://dx.doi.org/10.3389/fncel.2015.00167 Jayasena T; Poljak A; Braidy N; Smythe G; Raftery M; Hill M; Brodaty H; Trollor J; Kochan N; Sachdev P, 2015, 'Upregulation of glycolytic enzymes, mitochondrial dysfunction and increased cytotoxicity in glial cells treated with Alzheimer's disease plasma', PLoS One, vol. 10, no. 3, http://dx.doi.org/10.1371/journal.pone.0116092 Muenchhoff J; Poljak A; Song F; Raftery M; Brodaty H; Duncan M; McEvoy M; Attia J; Schofield PW; Sachdev PS, 2014, 'Plasma protein profiling of mild cognitive impairment and Alzheimer's disease across two independent cohorts', Journal of Alzheimer's Disease, vol. 43, no. 4, pp. 1355 - 1373, http://dx.doi.org/10.3233/JAD-141266 Braidy N; Poljak A; Grant R; Jayasena T; Mansour H; Chan-Ling T; Guillemin GJ; Smythe G; Sachdev P, 2014, 'Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence', Biogerontology, vol. 15, no. 2, pp. 177 - 198, http://dx.doi.org/10.1007/s10522-013-9489-5 Song F; Poljak A; Kochan NA; Raftery M; Brodaty H; Smythe GA; Sachdev PS, 2014, 'Plasma protein profiling of Mild Cognitive Impairment and Alzheimer's disease using iTRAQ quantitative proteomics', Proteome Science, vol. 12, no. 1, http://dx.doi.org/10.1186/1477-5956-12-5 Jayasena T; Poljak A; Smythe G; Braidy N; Münch G; Sachdev P, 2013, 'The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease', Ageing Research Reviews, vol. 12, no. 4, pp. 867 - 883, http://dx.doi.org/10.1016/j.arr.2013.06.003 Blumenthal A; Nagalingam G; Huch JH; Walker L; Guillemin GJ; Smythe GA; Ehrt S; Britton WJ; Saunders BM, 2012, 'M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection', PLoS One, vol. 7, no. 5, http://dx.doi.org/10.1371/journal.pone.0037314 Song F; Poljak A; Crawford J; Kochan NA; Wen W; Cameron B; Lux O; Brodaty H; Mather K; Smythe GA; Sachdev PS, 2012, 'Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals', PLoS One, vol. 7, no. 6, http://dx.doi.org/10.1371/journal.pone.0034078 Song F; Poljak A; Valenzuela M; Mayeux R; Smythe GA; Sachdev PS, 2011, 'Meta-analysis of plasma amyloid-β levels in Alzheimer's disease.', Journal of Alzheimer's Disease, vol. 26, no. 2, pp. 365 - 375 Song F; Poljak A; Smythe GA; Sachdev P, 2009, 'Plasma biomarkers for mild cognitive impairment and Alzheimer's disease', Brain Research Reviews, vol. 61, no. 2, pp. 69 - 80, http://dx.doi.org/10.1016/j.brainresrev.2009.05.003 Coggan SE; Smythe GA; Bilgin A; Grant RS, 2009, 'Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid', Journal of Neurochemistry, vol. 108, no. 5, pp. 1220 - 1225, http://dx.doi.org/10.1111/j.1471-4159.2009.05868.x Grant RS; Coggan SE; Smythe GA, 2009, 'The physiological action of picolinic acid in the human brain', International Journal of Tryptophan Research, vol. 2, no. 1, pp. 71 - 79 Abdul Majid AMS; Smythe G; Denny WA; Wakelin LPG, 2009, 'Mass spectrometry studies of the binding of the minor groove-directed alkylating agent alkamin to AT-Tract oligonucleotides', Chemical Research in Toxicology, vol. 22, no. 1, pp. 146 - 157, http://dx.doi.org/10.1021/tx800276h Hutton LC; Castillo-Melendez M; Smythe GA; Walker DW, 2008, 'Microglial activation, macrophage infiltration, and evidence of cell death in the fetal brain after uteroplacental administration of lipopolysaccharide in sheep in late gestation', American Journal of Obstetrics and Gynecology, vol. 198, no. 1, http://dx.doi.org/10.1016/j.ajog.2007.06.035 Owe-Young R; Webster NL; Mukhtar M; Pomerantz RJ; Smythe G; Walker D; Armati PJ; Crowe SM; Brew BJ, 2008, 'Kynurenine pathway metabolism in human blood-brain-barrier cells: Implications for immune tolerance & neurotoxicity', Journal of Neurochemistry, vol. 105, no. 4, pp. 1346 - 1357, http://dx.doi.org/10.1111/j.1471-4159.2008.05241.x Guelfi KJ; Ratnam N; Smythe GA; Jones TW; Fournier PA, 2007, 'Effect of intermittent high-intensity compared with continuous moderate exercise on glucose production and utilization in individuals with type 1 diabetes', American Journal of Physiology: Endocrinology and Metabolism, vol. 292, no. 3, http://dx.doi.org/10.1152/ajpendo.00533.2006 Matayatsuk C; Poljak A; Bustamante S; Smythe GA; Kalpravidh RW; Sirankapracha P; Fucharoen S; Wilairat P, 2007, 'Quantitative determination of ortho- and meta-tyrosine as biomarkers of protein oxidative damage in β-thalassemia', Redox Report, vol. 12, no. 5, pp. 219 - 228, http://dx.doi.org/10.1179/135100007X200272 Jayasena T; Grant RS; Keerthisinghe N; Solaja I; Smythe GA, 2007, 'Membrane permeability of redox active metal chelators: An important element in reducing hydroxyl radical induced NAD+ depletion in neuronal cells', Neuroscience Research, vol. 57, no. 3, pp. 454 - 461, http://dx.doi.org/10.1016/j.neures.2006.12.004 Majid AMSA; Smythe G; Denny WA; Wakelin LPG, 2007, 'Structure of the d(CGCGAATTCGCG)2 complex of the minor groove binding alkylating agent alkamin studied by mass spectrometry', Molecular Pharmacology, vol. 71, no. 4, pp. 1165 - 1178, http://dx.doi.org/10.1124/mol.106.030072 Abdul Majid AMS; Smythe G; Denny WA; Wakelin LPG, 2007, 'Erratum: Structure of the d(CGCGAATTCGCG)2 complex of the minor groove binding alkylating agent alkamin studied by mass spectrometry (Molecular Pharmacology (2007) 71 (1165-1178))', Molecular Pharmacology, vol. 72, no. 2, pp. 485, http://dx.doi.org/10.1124/mol.72.2.485