Sinclair, David - University of New South Wales

个人简介

David Sinclair, Ph.D. is a Professor at the School of Medicine at The University of New South Wales (UNSW), Sydney, and co-founder and co-chief editor of the scientific journal Aging. He is also a Professor in the Genetic Department at Harvard Medical School, Boston, Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging. He obtained a BS and a Ph.D. at UNSW in Molecular Genetics with Ian Dawes, worked as a postdoctoral researcher at M.I.T. with Lenny Guarente, before being hired at Harvard Medical School in 1999. He was promoted to tenured Professor in 2008. Dr. Sinclair's awards include the Australian Commonwealth Prize, a Helen Hay Whitney Postdoctoral Award, a Special Fellowship from the Leukemia Society, a Ludwig Scholarship, a Harvard-Armenise Fellowship, an American Association for Aging Research Fellowship, the Ellison Medical Foundation Scholarship and Senior Fellowship, the Genzyme Outstanding Achievement in Biomedical Science Award, Teluride Technology Award, Innovator of the Year, a MERIT Award from the NIA, the Nathan Shock Award, the David Murdock-Dole Lectureship, Excellence in Teaching at Harvard Medical School, the Fisher Lectureship, the Denham Harman Research Award, the ASMR Medal (Australian Society for Medical Research). He cofounded Sirtris Pharmaceuticals (Cambridge, MA; NASDAQ:SIRT), Genocea Biosciences (Cambridge, MA; NASDAQ:GNCA), OvaScience (Cambridge, MA; NASDAQ:OVAS), Cohbar and MetroBiotech and is a consultant for GlaxoSmithKline, InsideTracker, Metrobiotech, and Ovascience.

近期论文

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Garg N; Sinclair DA, 2015, 'Oogonial stem cells as a model to study age-associated infertility in women', Reproduction Fertility and Development, vol. 27, no. 6, pp. 969 - 974, http://dx.doi.org/10.1071/RD14461 Zhang QS; Deater M; Schubert K; Marquez-Loza L; Pelz C; Sinclair DA; Grompe M, 2015, 'The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice', Stem Cell Research, vol. 15, no. 1, pp. 130 - 140, http://dx.doi.org/10.1016/j.scr.2015.05.007 Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS One, vol. 10, no. 5, http://dx.doi.org/10.1371/journal.pone.0126194 Longo VD; Antebi A; Bartke A; Barzilai N; Brown-Borg HM; Caruso C; Curiel TJ; de Cabo R; Franceschi C; Gems D; Ingram DK; Johnson TE; Kennedy BK; Kenyon C; Klein S; Kopchick JJ; Lepperdinger G; Madeo F; Mirisola MG; Mitchell JR; Passarino G; Rudolph KL; Sedivy JM; Shadel GS; Sinclair DA; Spindler SR; Suh Y; Vijg J; Vinciguerra M; Fontana L, 2015, 'Interventions to Slow Aging in Humans: Are We Ready?', Aging Cell, http://dx.doi.org/10.1111/acel.12338 Cronise RJ; Sinclair DA; Bremer AA, 2014, 'The "metabolic winter" Hypothesis: A cause of the current epidemics of obesity and cardiometabolic disease', Metabolic Syndrome and Related Disorders, vol. 12, no. 7, pp. 355 - 361, http://dx.doi.org/10.1089/met.2014.0027 Moroz N; Carmona JJ; Anderson E; Hart AC; Sinclair DA; Blackwell TK, 2014, 'Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism', Aging Cell, vol. 13, no. 6, pp. 1075 - 1085, http://dx.doi.org/10.1111/acel.12273 Rimmelé P; Bigarella CL; Liang R; Izac B; Dieguez-Gonzalez R; Barbet G; Donovan M; Brugnara C; Blander JM; Sinclair DA; Ghaffari S, 2014, 'Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells', Stem Cell Reports, vol. 3, no. 1, pp. 44 - 59, http://dx.doi.org/10.1016/j.stemcr.2014.04.015 North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA; Van Deursen JM; Rosenzweig A; Sinclair DA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', The EMBO Journal, vol. 33, no. 13, pp. 1438 - 1453, http://dx.doi.org/10.15252/embj.201386907 Mitchell SJ; Martin-Montalvo A; Mercken EM; Palacios HH; Ward TM; Abulwerdi G; Minor RK; Vlasuk GP; Ellis JL; Sinclair DA; Dawson J; Allison DB; Zhang Y; Becker KG; Bernier M; De Cabo R, 2014, 'The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet', Cell Reports, vol. 6, no. 5, pp. 836 - 843, http://dx.doi.org/10.1016/j.celrep.2014.01.031 Wu LE; Sinclair DA, 2014, 'SIRT2 controls the pentose phosphate switch', The EMBO Journal, vol. 33, no. 12, pp. 1287 - 1288, http://dx.doi.org/10.15252/embj.201488713 Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, vol. 19, no. 3, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009 Mercken EM; Mitchell SJ; Martin-Montalvo A; Minor RK; Almeida M; Gomes AP; Scheibye-Knudsen M; Palacios HH; Licata JJ; Zhang Y; Becker KG; Khraiwesh H; González-Reyes JA; Villalba JM; Baur JA; Elliott P; Westphal C; Vlasuk GP; Ellis JL; Sinclair DA; Bernier M; De Cabo R, 2014, 'SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass', Aging Cell, http://dx.doi.org/10.1111/acel.12220 Michan S; Juan AM; Hurst CG; Cui Z; Evans LP; Hatton CJ; Pei DT; Ju M; Sinclair DA; Smith LEH; Chen J, 2014, 'Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy', PLoS One, vol. 9, no. 1, http://dx.doi.org/10.1371/journal.pone.0085031 Hubbard BP; Sinclair DA, 2014, 'Small molecule SIRT1 activators for the treatment of aging and age-related diseases', Trends in Pharmacological Sciences, vol. 35, no. 3, pp. 146 - 154, http://dx.doi.org/10.1016/j.tips.2013.12.004 Yoon JC; Ling AJY; Isik M; Donna Lee DY; Steinbaugh MJ; Sack LM; Boduch AN; Blackwell TK; Sinclair DA; Elledge SJ, 2014, 'GLTSCR2/PICT1 links mitochondrial stress and Myc signaling', Proceedings of the National Academy of Sciences of USA, vol. 111, no. 10, pp. 3781 - 3786, http://dx.doi.org/10.1073/pnas.1400705111 Fillman SG; Sinclair D; Fung SJ; Shannon Weickert C; Webster MJ, 2014, 'Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder', Translational Psychiatry, vol. 4, http://dx.doi.org/10.1038/tp.2014.8 Wu L; Gomes A; Sinclair D, 2014, 'Geroncogenesis: Metabolic changes during aging as a driver of tumorigenesis', Cancer Cell, vol. 25, no. 1, pp. 12 - 19, http://dx.doi.org/10.1016/j.ccr.2013.12.005 Sinclair DA; Guarente L, 2014, 'Small-molecule allosteric activators of sirtuins', Annual Review of Pharmacology and Toxicology, vol. 54, pp. 363 - 380, http://dx.doi.org/10.1146/annurev-pharmtox-010611-134657 Sinclair DA, 2013, 'Studying the replicative life span of yeast cells', Methods in Molecular Biology, vol. 1048, pp. 49 - 63, http://dx.doi.org/10.1007/978-1-62703-556-9_5 Strong R; Miller RA; Astle CM; Baur JA; De Cabo R; Fernandez E; Guo W; Javors M; Kirkland JL; Nelson JF; Sinclair DA; Teter B; Williams D; Zaveri N; Nadon NL; Harrison DE, 2013, 'Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice', Journal of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 68, no. 1, pp. 6 - 16, http://dx.doi.org/10.1093/gerona/gls070