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研究领域

Cell Metabolism

My research interest mainly focuses on the characterisation of metabolic dysfunctions and the critical role played by the immune system in the development of those alterations in metabolic and immune conditions.

近期论文

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Raghuraman S; Donkin I; Versteyhe S; Barrès R; Simar D, 2016, 'The Emerging Role of Epigenetics in Inflammation and Immunometabolism.', Trends in Endocrinology and Metabolism, http://dx.doi.org/10.1016/j.tem.2016.06.008 Jacobsen MJ; Mentzel CM; Olesen AS; Huby T; Jørgensen CB; Barrès R; Fredholm M; Simar D, 2016, 'Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity.', Journal of Diabetes Research, vol. 2016, pp. 8539057, http://dx.doi.org/10.1155/2016/8539057 Simpson KA; Mavros Y; Kay S; Meiklejohn J; de Vos N; Wang Y; Guo Q; Zhao R; Climstein M; Baune BT; Blair S; O'Sullivan AJ; Simar D; Singh N; Singh MA, 2015, 'Graded Resistance Exercise And Type 2 Diabetes in Older adults (The GREAT2DO study): methods and baseline cohort characteristics of a randomized controlled trial.', Trials, vol. 16, pp. 512, http://dx.doi.org/10.1186/s13063-015-1037-y Chan YL; Saad S; Simar D; Oliver B; McGrath K; Reyk DV; Bertrand PP; Gorrie C; Pollock C; Chen H, 2015, 'Short term exendin-4 treatment reduces markers of metabolic disorders in female offspring of obese rat dams.', International Journal of Developmental Neuroscience, vol. 46, pp. 67 - 75, http://dx.doi.org/10.1016/j.ijdevneu.2015.05.009 Caillaud C; Mechta M; Ainge H; Madsen AN; Ruell P; Mas E; Bisbal C; Mercier J; Twigg S; Mori TA; Simar D; Barrès R, 2015, 'Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats.', Journal of Endocrinology, vol. 225, no. 2, pp. 77 - 88, http://dx.doi.org/10.1530/JOE-15-0010 Martinez D; Palmer C; Simar D; Cameron BA; Nguyen N; Aggarwal V; Lloyd AR; Zekry A, 2015, 'Characterisation of the cytokine milieu associated with the up-regulation of IL-6 and suppressor of cytokine 3 in chronic hepatitis C treatment non-responders.', Liver International, vol. 35, no. 2, pp. 463 - 472, http://dx.doi.org/10.1111/liv.12473 Simar D; Versteyhe S; Donkin I; Liu J; Hesson L; Nylander V; Fossum A; Barrès R, 2014, 'DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human.', Metabolism: clinical and experimental, vol. 63, no. 9, pp. 1188 - 1197, http://dx.doi.org/10.1016/j.metabol.2014.05.014 Mavros Y; Kay S; Simpson KA; Baker MK; Wang Y; Zhao RR; Meiklejohn J; Climstein M; O'Sullivan AJ; de Vos N; Baune BT; Blair SN; Simar D; Rooney K; Singh NA; Fiatarone Singh MA, 2014, 'Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training.', Journal of Cachexia, Sarcopenia and Muscle, vol. 5, no. 2, pp. 111 - 120, http://dx.doi.org/10.1007/s13539-014-0134-1 Ruell PA; Simar D; Périard JD; Best S; Caillaud C; Thompson MW, 2014, 'Plasma and lymphocyte Hsp72 responses to exercise in athletes with prior exertional heat illness.', Amino Acids, vol. 46, no. 6, pp. 1491 - 1499, http://dx.doi.org/10.1007/s00726-014-1721-3 Chen H; Simar D; Pegg K; Saad S; Palmer C; Morris MJ, 2014, 'Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents.', Diabetologia, vol. 57, no. 3, pp. 614 - 622, http://dx.doi.org/10.1007/s00125-013-3132-5 Chen H; Simar D; Morris MJ, 2014, 'Maternal obesity impairs brain glucose metabolism and neural response to hyperglycemia in male rat offspring.', Journal of Neurochemistry, vol. 129, no. 2, pp. 297 - 303, http://dx.doi.org/10.1111/jnc.12623 Mavros Y; Kay S; Anderberg KA; Baker MK; Wang Y; Zhao R; Meiklejohn J; Climstein M; O'Sullivan A; de Vos N; Baune BT; Blair SN; Simar D; Rooney K; Singh N; Fiatarone Singh MA, 2013, 'Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with type 2 diabetes: interim outcomes from the GREAT2DO trial.', Diabetes Care, vol. 36, no. 8, pp. 2372 - 2379, http://dx.doi.org/10.2337/dc12-2196 Simar D; Chen H; Lambert K; Mercier J; Morris MJ, 2012, 'Interaction between maternal obesity and post-natal over-nutrition on skeletal muscle metabolism.', Nutrition Metabolism and Cardiovascular Diseases, vol. 22, no. 3, pp. 269 - 276, http://dx.doi.org/10.1016/j.numecd.2010.11.007 Simar D; Malatesta D; Mas E; Delage M; Caillaud C, 2012, 'Effect of an 8-weeks aerobic training program in elderly on oxidative stress and HSP72 expression in leukocytes during antioxidant supplementation.', The Journal of Nutrition Health and Aging, vol. 16, no. 2, pp. 155 - 161, http://www.ncbi.nlm.nih.gov/pubmed/22323351 Simar D; Jacques A; Caillaud C, 2012, 'Heat shock proteins induction reduces stress kinases activation, potentially improving insulin signalling in monocytes from obese subjects.', Cell Stress and Chaperones, vol. 17, no. 5, pp. 615 - 621, http://dx.doi.org/10.1007/s12192-012-0336-4 Chen H; Simar D; Ting JH; Erkelens JR; Morris MJ, 2012, 'Leucine improves glucose and lipid status in offspring from obese dams, dependent on diet type, but not caloric intake.', Journal of Neuroendocrinology, vol. 24, no. 10, pp. 1356 - 1364, http://dx.doi.org/10.1111/j.1365-2826.2012.02339.x Maïmoun L; Simar D; Caillaud C; Coste O; Puech AM; Jaussent A; Mariano-Goulart D; Sultan C, 2011, 'Basal plasma leptin levels in healthy elderly males are related to physical fitness without impact on bone metabolism.', The Journal of Sports Medicine and Physical Fitness, vol. 51, no. 1, pp. 160 - 168, http://www.ncbi.nlm.nih.gov/pubmed/21297576 Wang Y; Simar D; Anderberg K; Mavros Y; Kay S; Zhao R; Baune BT; O’Sullivan A; Singh N; Singh MF, 2011, 'Muscle and adipose tissue biopsy in older adults with type 2 diabetes', Journal of Diabetes Mellitus, vol. 01, no. 03, pp. 27 - 35, http://dx.doi.org/10.4236/jdm.2011.13005 Malatesta D; Simar D; Ben Saad H; Préfaut C; Caillaud C, 2010, 'Effect of an overground walking training on gait performance in healthy 65- to 80-year-olds.', Experimental Gerontology, vol. 45, no. 6, pp. 427 - 434, http://dx.doi.org/10.1016/j.exger.2010.03.009 Maïmoun L; Simar D; Caillaud C; Coste O; Barbotte E; Peruchon E; Rossi M; Mariano-Goulart D, 2009, 'Response of calciotropic hormones and bone turnover to brisk walking according to age and fitness level.', Journal of Science and Medicine in Sport, vol. 12, no. 4, pp. 463 - 467, http://dx.doi.org/10.1016/j.jsams.2008.05.004

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