研究领域

Cancer; Cell Biology and Gene Regulation; Biochemistry; Genetics - Genome Analysis; Biochemistry

Our research is focused on proteostasis and metabolic reprogramming in cancer and neurodegeneration, integrating various platforms (including proteomics, genomics, and metabolomics) to better understand genotype-phenotype relationships. I have a long-standing interest in protein homeostasis (proteostasis), publishing numerous manuscripts providing mechanistic insights into serpin biology and the Ubiquitin-proteasome system, with more recent work aimed at characterising novel mutations involved in protein misfolding and Ub systems in various disease states. I developed a novel platform for screening protein-protein interactions in situ, and novel proteomics approaches to systematically identify E3 Ub ligase substrates and for exploring interactome diversity in cell signalling. We use a number of models systems including patient-derived iPS cells, patient derived tumour xenografts and transgenic models of cancer and neurodegeneration. I am also collaborating to develop creative technology-based approaches to visualizing and communicating complex data, using music to explore the intersection between genetics and environment. I am an active science communicator, makes regular radio and TV appearances, and contributions to print and online media. I developed and presented the Cancer in the Community education campaign targeting rural/regional Australia and contribute to policy development through the Australia2050 and Future Earth Australia projects.

近期论文

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Liu L; Phua YW; Lee RS; Ma X; Jenkins Y; Novy K; Humphrey ES; Chan H; Shearer R; Ong PC; Dai W; Saunders DN; Lucet IS; Daly RJ, 2016, 'Homo- and Heterotypic Association Regulates Signalling by the SgK269/PEAK1 and SgK223 Pseudokinases.', Journal of Biological Chemistry, http://dx.doi.org/10.1074/jbc.M116.748897 Croucher DR; Iconomou M; Hastings JF; Kennedy SP; Han JZR; Shearer RF; McKenna J; Wan A; Lau J; Aparicio S; Saunders DN, 2016, 'Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers', Science Signaling, vol. 9, no. 436, http://dx.doi.org/10.1126/scisignal.aaf0793 Yerbury JJ; Ooi L; Dillin A; Saunders DN; Hatters DM; Beart PM; Cashman NR; Wilson MR; Ecroyd H, 2016, 'Walking the tightrope: proteostasis and neurodegenerative disease.', Journal of Neurochemistry, vol. 137, no. 4, pp. 489 - 505, http://dx.doi.org/10.1111/jnc.13575 Shearer RF; Iconomou M; Watts CKW; Saunders DN, 2015, 'Functional roles of the E3 Ubiquitin Ligase UBR5 in cancer', Molecular Cancer Research, vol. 13, no. 12, pp. 1523 - 1532, http://dx.doi.org/10.1158/1541-7786.MCR-15-0383 Farrawell NE; Lambert-Smith IA; Warraich ST; Blair IP; Saunders DN; Hatters DM; Yerbury JJ, 2015, 'Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep13416 Lee JA; Yerbury JJ; Farrawell N; Shearer RF; Constantinescu P; Hatters DM; Schroder WA; Suhrbier A; Wilson MR; Saunders DN; Ranson M, 2015, 'SerpinB2 (PAI-2) modulates proteostasis via binding misfolded proteins and promotion of cytoprotective inclusion formation', PLoS One, vol. 10, no. 6, http://dx.doi.org/10.1371/journal.pone.0130136 Shearer RF; Saunders DN, 2015, 'Experimental design for stable genetic manipulation in mammalian cell lines: Lentivirus and alternatives', Genes to Cells, vol. 20, no. 1, pp. 1 - 10, http://dx.doi.org/10.1111/gtc.12183 Falkenberg KJ; Simpson KJ, 2014, 'A high-throughput, multiplex cell death assay using an RNAi screening approach', Cold Spring Harbor protocols, vol. 2014, no. 6, pp. 663 - 676, http://dx.doi.org/10.1101/pdb.prot080267 Saunders DN; Falkenberg KJ; Simpson KJ, 2014, 'High-throughput approaches to measuring cell death', Cold Spring Harbor protocols, vol. 2014, no. 6, pp. 591 - 601, http://dx.doi.org/10.1101/pdb.top072561 Ong SS; Goktug AN; Elias A; Wu J; Saunders D; Chen T, 2014, 'Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2', Biochemical Journal, vol. 459, no. 1, pp. 193 - 203, http://dx.doi.org/10.1042/BJ20130558 Croucher DR; Hochgräfe F; Zhang L; Liu L; Lyons RJ; Rickwood D; Tactacan CM; Browne BC; Ali N; Chan H; Shearer R; Gallego-Ortega D; Saunders DN; Swarbrick A; Daly RJ, 2013, 'Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway', Cancer Research, vol. 73, no. 6, pp. 1969 - 1980, http://dx.doi.org/10.1158/0008-5472.CAN-12-1472 Röring M; Herr R; Fiala GJ; Heilmann K; Braun S; Eisenhardt AE; Halbach S; Capper D; Von Deimling A; Schamel WW; Saunders DN; Brummer T, 2012, 'Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling', The EMBO Journal, vol. 31, no. 11, pp. 2629 - 2647, http://dx.doi.org/10.1038/emboj.2012.100 Gudjonsson T; Altmeyer M; Savic V; Toledo L; Dinant C; Grøfte M; Bartkova J; Poulsen M; Oka Y; Bekker-Jensen S; Mailand N; Neumann B; Heriche JK; Shearer R; Saunders D; Bartek J; Lukas J; Lukas C, 2012, 'TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes', Cell, vol. 150, no. 4, pp. 697 - 709, http://dx.doi.org/10.1016/j.cell.2012.06.039 Saunders DN; Tindall EA; Shearer RF; Roberson J; Decker A; Wilson JA; Hayes VM, 2012, 'A Novel SERPINA1 Mutation Causing Serum Alpha1-Antitrypsin Deficiency', PLoS One, vol. 7, no. 12, http://dx.doi.org/10.1371/journal.pone.0051762 Hu G; Wang X; Saunders DN; Henderson M; Russell AJ; Herring BP; Zhou J, 2011, 'Modulation of myocardin function by the ubiquitin E3 ligase UBR5 (The Journal Of Biological Chemistry (2010) 9285, (11800-11809))', Journal of Biological Chemistry, vol. 286, no. 28, pp. 25416, http://dx.doi.org/10.1074/jbc.A109.079384 Schrader KA; Masciari S; Boyd N; Salamanca C; Senz J; Saunders DN; Yorida E; Maines-Bandiera S; Kaurah P; Tung N; Robson ME; Ryan PD; Olopade OI; Domchek SM; Ford J; Isaacs C; Brown P; Balmana J; Razzak AR; Miron P; Coffey K; Terry MB; John EM; Andrulis IL; Knight JA; O'Malley FP; Daly M; Bender P; Moore R; Southey MC; Hopper JL; Garber JE; Huntsman DG, 2011, 'Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers', Journal of Medical Genetics, vol. 48, no. 1, pp. 64 - 68, http://dx.doi.org/10.1136/jmg.2010.079814 Cochran BJ; Croucher DR; Lobov S; Saunders DN; Ranson M, 2011, 'Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of serpinE1 and serpinB2 in cancer', Journal of Biological Chemistry, vol. 286, no. 27, pp. 24467 - 24475, http://dx.doi.org/10.1074/jbc.M111.225706 Watts CK; Saunders DN, 2011, 'Effects of EDD on p53 function are context-specific', Journal of Biological Chemistry, vol. 286, no. 28, http://dx.doi.org/10.1074/jbc.L110.182527 Watts CK; Saunders D, 2011, 'Effects of EDD on p53 function are context-specific', Journal of Biological Chemistry, vol. 286, pp. 1 - 13, http://dx.doi.org/10.1074/jbc.N110.182527 Hu G; Wang X; Saunders DN; Henderson M; Russell AJ; Herring BP; Zhou J, 2010, 'Modulation of myocardin function by the ubiquitin E3 ligase UBR', Journal of Biological Chemistry, vol. 285, no. 16, pp. 11800 - 11809, http://dx.doi.org/10.1074/jbc.M109.079384