研究领域

Physiology, Cardiology and Vascular Disease, Anatomy, Pharmacology, Neuroscience

Working with colleagues in Australia, Canada, Britain and the US, our studies aim to determine some of the ways that cells in arteries communicate with one another and specifically, at how cells control the balance between the way that arteries narrow (constrict) and enlarge (dilate). This balance is referred to as vascular tone and is the main determinant of blood pressure and thus cardiovascular disease. Coordination of vascular tone is dependent on signals passing through junctions within and between the cellular layers in arteries. Our studies correlate anatomy and function, to identify the fundamental pathways that underlie blood vessel function.

近期论文

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Bertrand PP; Polglaze KE; Chen H; Sandow SL; Walduck A; Jenkins TA; Bertrand RL; Lomax AE; Liu L, 2016, 'Excitability and Synaptic Transmission in the Enteric Nervous System: Does Diet Play a Role?', Advances in Experimental Medicine and Biology, vol. 891, pp. 201 - 211, http://dx.doi.org/10.1007/978-3-319-27592-5_19 Murphy TV; Kanagarajah A; Toemoe S; Bertrand PP; Grayson TH; Britton FC; Leader L; Senadheera S; Sandow SL, 2016, 'TRPV3 expression and vasodilator function in isolated uterine radial arteries from non-pregnant and pregnant rats', Vascular Pharmacology, vol. 83, pp. 66 - 77, http://dx.doi.org/10.1016/j.vph.2016.04.004 Kerr PM; Wei R; Tam R; Sandow SL; Murphy TV; Ondrusova K; Lunn SE; Tran CHT; Welsh DG; Plane F, 2015, 'Activation of endothelial IKCa channels underlies NO-dependent myoendothelial feedback', Vascular Pharmacology, vol. 74, pp. 130 - 138, http://dx.doi.org/10.1016/j.vph.2015.09.001 Holobotovskyy V; Chong YS; Burchell J; He B; Phillips M; Leader L; Murphy TV; Sandow SL; McKitrick DJ; Charles AK; Tare M; Arnolda LF; Ganss R, 2015, 'Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia', Science Translational Medicine, vol. 7, no. 290, http://dx.doi.org/10.1126/scitranslmed.aaa5038 Froud KE; Wong ACY; Cederholm JME; Klugmann M; Sandow SL; Julien JP; Ryan AF; Housley GD, 2015, 'Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms8115 Diezmos EF; Sandow SL; Perera DS; King DW; Bertrand PP; Liu L, 2015, 'Pannexin-2 is expressed in the human colon with extensive localization in the enteric nervous system', Neurogastroenterology and Motility, http://dx.doi.org/10.1111/nmo.12541 Bertrand PP; Polglaze KE; Bertrand RL; Sandow SL; Pozo MJ, 2014, 'Detection of melatonin production from the intestinal epithelium using electrochemical methods', Current Pharmaceutical Design, vol. 20, no. 30, pp. 4802 - 4806, http://dx.doi.org/10.2174/1381612819666131119105421 Hald BO; Jacobsen JCB; Sandow SL; Holstein-Rathlou NH; Welsh DG, 2014, 'Less is more: Minimal expression of myoendothelial gap junctions optimizes cell-cell communication in virtual arterioles', The Journal of Physiology, vol. 592, no. 15, pp. 3243 - 3255, http://dx.doi.org/10.1113/jphysiol.2014.272815 Jelinic M; Leo CH; Post Uiterweer ED; Sandow SL; Gooi JH; Wlodek ME; Conrad KP; Parkington H; Tare M; Parry LJ, 2014, 'Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment', The FASEB Journal, vol. 28, no. 1, pp. 275 - 287, http://dx.doi.org/10.1096/fj.13-233429 Howitt L; Morris MJ; Sandow SL; Murphy TV, 2014, 'Effect of diet-induced obesity on BKCa function in contraction and dilation of rat isolated middle cerebral artery', Vascular Pharmacology, vol. 61, no. 1, pp. 10 - 15, http://dx.doi.org/10.1016/j.vph.2014.02.002 Ellinsworth DC; Earley S; Murphy TV; Sandow SL, 2014, 'Endothelial control of vasodilation: Integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids', Pfluegers Archiv: European journal of physiology, vol. 466, no. 3, pp. 389 - 405, http://dx.doi.org/10.1007/s00424-013-1303-3 Kuo IY-T; Howitt L; McFarlane A; Hill CE; Sandow SL; Hansen PB, 2014, 'Role of T-type channels in vasomotor function: team player or chameleon?', Pfluegers Archiv: European journal of physiology, pp. 1 - 13, http://dx.doi.org/10.1007/s00424-013-1430-x Wang K; Bertrand RL; Senadheera S; Polglaze KE; Murphy TV; Sandow SL; Bertrand PP; Liu L; Bornstein JC, 2013, 'Motility changes induced by intraluminal FeSO in guinea pig jejunum', Neurogastroenterology and Motility, http://dx.doi.org/10.1111/nmo.12276 Senadheera S; Bertrand PP; Grayson TH; Leader L; Murphy TV; Sandow SL, 2013, 'Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveola', Journal of Anatomy, vol. 223, no. 6, pp. 677 - 686, http://dx.doi.org/10.1111/joa.12127 Senadheera S; Bertrand PP; Grayson TH; Leader L; Tare M; Murphy TV; Sandow SL, 2013, 'Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 305, no. 8, http://dx.doi.org/10.1152/ajpregu.00225.2013 Howitt L; Chaston DJ; Sandow SL; Matthaei KI; Edwards FR; Hill CE, 2013, 'Spreading vasodilatation in the murine microcirculation: Attenuation by oxidative stress-induced change in electromechanical coupling', The Journal of Physiology, vol. 591, no. 8, pp. 2157 - 2173, http://dx.doi.org/10.1113/jphysiol.2013.250928 Grayson TH; Chadha PS; Bertrand PP; Chen H; Morris MJ; Senadheera S; Murphy TV; Sandow SL, 2013, 'Increased caveolae density and caveolin-1 expression accompany impaired NO-mediated vasorelaxation in diet-induced obesity', Histochemistry and Cell Biology, vol. 139, no. 2, pp. 309 - 321, http://dx.doi.org/10.1007/s00418-012-1032-2 Diezmos EF; Sandow SL; Markus I; Shevy Perera D; Lubowski DZ; King DW; Bertrand PP; Liu L, 2013, 'Expression and localization of pannexin-1 hemichannels in human colon in health and disease', Neurogastroenterology and Motility, vol. 25, no. 6, http://dx.doi.org/10.1111/nmo.12130 Plane F; Tam R; Sandow S; Kerr P, 2012, 'What did the smooth muscle cell say to the endothelial cell?', Canadian Journal of Physiology and Pharmacology, vol. 90, no. 6, pp. 674 - 674, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000304531700024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Chen H; Saad S; Sandow SL; Bertrand PP, 2012, 'Cigarette smoking and brain regulation of energy homeostasis', Frontiers in Pharmacology, vol. 3 JUL, http://dx.doi.org/10.3389/fphar.2012.00147