Poole, Kate - University of New South Wales - School of Medical Sciences

个人简介

Dr Kate Poole received her PhD from the University of Adelaide in 2002 before moving to Germany to undertake postdoctoral studies. Whilst in Germany Kate worked at the Max Planck Institute for Molecular Cell Biology and Genetics and the Technische Universitaet Dresden. Kate then spent a couple of years working in industry for the atomic force microscopy company JPK Instruments, AG. In 2008 Kate returned to science, taking a postdoctoral position at the Max Delbruck Center for Molecular Medicine. In 2012, Kate received the Cecile Vogt Fellowship which allowed her to establish her research independance, also at the Max Delbruck Center. Kate has recently returned from Germany to join the Department of Physiology, School of Medical Sciences, as a lecturer. Her research interests revolve around understanding how cells sense their physical environment. The sensing of and discrimination between different physical inputs is critical in the function of many cells and tissues in multicellular organisms; an acute response to mechanical stimuli underpins our senses of touch and hearing, integrated sensing of changing mechanical loads is fundamental for maintaining cartilage and the vasculature, and migratory cells (such as fibroblasts in wound healing or tumour cells during metastasis) can probe the mechanical properties of their surroundings by applying forces at cell-matrix contact points. Kate is studying the molecular mechanisms of cellular sensing of physical stimuli across a number of mammalian systems: in touch sensation in the somatic sensory system, the homeostatic maintenance of cartilage and in melanoma progression and metastasis.

研究领域

Animal Cell and Molecular Biology

近期论文

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Grandin M; Meier M; Delcros JG; Nikodemus D; Reuten R; Patel TR; Goldschneider D; Orriss G; Krahn N; Boussouar A; Abes R; Dean Y; Neves D; Bernet A; Depil S; Schneiders F; Poole K; Dante R; Koch M; Mehlen P; Stetefeld J, 2016, 'Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers', Cancer Cell, vol. 29, no. 2, pp. 173 - 185, http://dx.doi.org/10.1016/j.ccell.2016.01.001 Poole K; Herget R; Lapatsina L; Ngo HD; Lewin GR, 2014, 'Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms4520 Poole K; Moroni M; Lewin GR, 2014, 'Sensory mechanotransduction at membrane-matrix interfaces', Pfluegers Archiv: European journal of physiology, vol. 467, no. 1, pp. 121 - 132, http://dx.doi.org/10.1007/s00424-014-1563-6 Lapatsina L; Brand J; Poole K; Daumke O; Lewin GR, 2012, 'Stomatin-domain proteins', European Journal of Cell Biology, vol. 91, no. 4, pp. 240 - 245, http://dx.doi.org/10.1016/j.ejcb.2011.01.018 Long D; Wilkinson KL; Poole K; Taylor DK; Warren T; Astorga AM; Jiranek V, 2012, 'Rapid method for proline determination in grape juice and wine', Journal of Agricultural and Food Chemistry, vol. 60, no. 17, pp. 4259 - 4264, http://dx.doi.org/10.1021/jf300403b Lapatsina L; Jira JA; Smith ESJ; Poole K; Kozlenkov A; Bilbao D; Lewin GR; Heppenstall PA, 2012, 'Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons', Open Biology, vol. 2, no. JUNE, http://dx.doi.org/10.1098/rsob.120096 Brand J; Smith ESJ; Schwefel D; Lapatsina L; Poole K; Omerbašić D; Kozlenkov A; Behlke J; Lewin GR; Daumke O, 2012, 'A stomatin dimer modulates the activity of acid-sensing ion channels', The EMBO Journal, vol. 31, no. 17, pp. 3635 - 3646, http://dx.doi.org/10.1038/emboj.2012.203 Chiang LY; Poole K; Oliveira BE; Duarte N; Sierra YAB; Bruckner-Tuderman L; Koch M; Hu J; Lewin GR, 2011, 'Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons', Nature Neuroscience, vol. 14, no. 8, pp. 993 - 1000, http://dx.doi.org/10.1038/nn.2873 Lechner SG; Markworth S; Poole K; Smith ESJ; Lapatsina L; Frahm S; May M; Pischke S; Suzuki M; Ibañez-Tallon I; Luft FC; Jordan J; Lewin GR, 2011, 'The molecular and cellular identity of peripheral osmoreceptors', Neuron, vol. 69, no. 2, pp. 332 - 344, http://dx.doi.org/10.1016/j.neuron.2010.12.028 Poole K; Walker ME; Warren T; Gardner J; McBryde C; Lopes MDB; Jiranek V, 2009, 'Proline transport and stress tolerance of ammonia-insensitive mutants of the PUT4-encoded proline-specific permease in yeast', The Journal of General and Applied Microbiology, vol. 55, no. 6, pp. 427 - 439, http://dx.doi.org/10.2323/jgam.55.427 Ludwig T; Kirmse R; Poole K; Schwarz US, 2008, 'Probing cellular microenvironments and tissue remodeling by atomic force microscopy', Pfluegers Archiv: European journal of physiology, vol. 456, no. 1, pp. 29 - 49, http://dx.doi.org/10.1007/s00424-007-0398-9 Puech PH; Poole K; Knebel D; Muller DJ, 2006, 'A new technical approach to quantify cell-cell adhesion forces by AFM', Ultramicroscopy, vol. 106, no. 8-9, pp. 637 - 644, http://dx.doi.org/10.1016/j.ultramic.2005.08.003 Poole K; Müller D, 2005, 'Flexible, actin-based ridges colocalise with the β1 integrin on the surface of melanoma cells', British Journal of Cancer, vol. 92, no. 8, pp. 1499 - 1505, http://dx.doi.org/10.1038/sj.bjc.6602515 Poole K; Khairy K; Friedrichs J; Franz C; Cisneros DA; Howard J; Mueller D; Baumeister W, 2005, 'Molecular-scale topographic cues induce the orientation and directional movement of fibroblasts on two-dimensional collagen surfaces', Journal of Molecular Biology, vol. 349, no. 2, pp. 380 - 386, http://dx.doi.org/10.1016/j.jmb.2005.03.064 Poole K; Müller DJ, 2005, 'Connections between surface structure and functional state of cell membrane of cancer cells', BioSpektrum, vol. 11, no. 4, pp. 465 - 466 Poole K; Meder D; Simons K; Müller D, 2004, 'The effect of raft lipid depletion on microvilli formation in MDCK cells, visualized by atomic force microscopy', FEBS Letters, vol. 565, no. 1-3, pp. 53 - 58, http://dx.doi.org/10.1016/j.febslet.2004.03.095 Jiang F; Khairy K; Poole K; Howard J; Müller DJ, 2004, 'Creating nanoscopic collagen matrices using atomic force microscopy', Microscopy Research and Technique, vol. 64, no. 5-6, pp. 435 - 440, http://dx.doi.org/10.1002/jemt.20101 Gardner JM; Poole K; Jiranek V, 2002, 'Practical significance of relative assimilable nitrogen requirements of yeast: A preliminary study of fermentation performance and liberation of H2S', Australian Journal of Grape and Wine Research, vol. 8, no. 3, pp. 175 - 179