个人简介
1992 BSc (Hons I) School of Pathology, UNSW
1997 PhD, Garvan Institute of Medical Research, UNSW
Fellowships and Appointments
1997-1999 Alexander von Humboldt Fellow, Heinrich Heine Universitaet, Germany
2000-2002 NHMRC Howard Florey Fellow, Children’s Medical Research Institute, Sydney
2002 JSPS Short Term Visiting Fellow, National Institute of Advanced Industrial Science and Technology (AIST), Institute of Molecular and Cell Biology, Japan
2003-2004 Senior Research Scientist, Children’s Medical Research Institute, Sydney
2004-2009 Lecturer, Department of Pathology, School of Medical Sciences, UNSW
2007- Present Senior Research Fellow Conjoint; USyd, NSW
2007- Present Group Leader, Cancer Cachexia Mechanisms Research Group, Department of Pathology, SoMS UNSW Australia
2009-2015 Senior Lecturer, Department of Pathology, School of Medical Sciences, UNSW Australia
2012-2015 Associate Professor (Conjoint), School of Medical Science, Griffith University, Queensland, Australia
2015-Present Associate Professor, Department of Pathology, School of Medical Sciences, UNSW Medicine, UNSW Australia
2015-Present Deputy Head, Department of Pathology, School of Medical Sciences, UNSW Medicine, UNSW Australia
2016 UNSW Teaching Fellow
近期论文
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Isaac ST; Tan TC; Polly P, 2016, 'Endoplasmic Reticulum Stress, Calcium Dysregulation and Altered Protein Translation: Intersection of Processes That Contribute to Cancer Cachexia Induced Skeletal Muscle Wasting.', Current Drug Targets, vol. 17, no. 10, pp. 1140 - 1146, http://www.ncbi.nlm.nih.gov/pubmed/25882219
Shum AMY; Fung DCY; Corley SM; McGill MC; Bentley NL; Tan TC; Wilkins MR; Polly P, 2015, 'Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia', Physiological Genomics, vol. 47, no. 12, pp. 588 - 599, http://dx.doi.org/10.1152/physiolgenomics.00128.2014
Wong M; Polly P; Liu T, 2015, 'The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.', American Journal of Cancer Research, vol. 5, no. 9, pp. 2823 - 2837, http://www.ncbi.nlm.nih.gov/pubmed/26609488
Polly P; Velan GM; Hawkins N, 2015, 'Development of Online Science Practical Lesson Resources to Enhance Student Learning in Phases 1 and 2 Medicine at UNSW Australia.', Proceedings of E-Learn: World Conference on E-Learning in Corporate, Government, Healthcare, and Higher Education 2015, pp. 1452 - 1458, http://www.editlib.org/pv/152202/
Polly P; Marcus N; Maguire D; Belinson Z; Velan GM, 2014, 'Evaluation of an adaptive virtual laboratory environment using Western Blotting for diagnosis of disease', BMC Medical Education, vol. 14, pp. 222, http://dx.doi.org/10.1186/1472-6920-14-222
Polly P; Marcus N; Maguire D; Belinson Z; Velan GM, 2014, 'Evaluation of an adaptive virtual laboratory environment using Western Blotting for diagnosis of disease', BMC Medical Education, pp. 1 - 9, http://dx.doi.org/10.1186/1472-6920-14-222
Liu PY; Erriquez D; Marshall GM; Tee AE; Polly P; Wong M; Liu B; Bell JL; Zhang XD; Milazzo G; Cheung BB; Fox A; Swarbrick A; Hüttelmaier S; Kavallaris M; Perini G; Mattick JS; Dinger ME; Liu T, 2014, 'Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression', Journal of the National Cancer Institute, vol. 106, no. 7, http://dx.doi.org/10.1093/jnci/dju113
Ittner AA; Bertz J; Chan TYB; Van Eersel J; Polly P; Ittner LM, 2014, 'The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo', Diabetologia, vol. 57, no. 7, pp. 1410 - 1419, http://dx.doi.org/10.1007/s00125-014-3230-z
Polly P; Tan TC, 2014, 'The role of vitamin D in skeletal and cardiac muscle function', Frontiers in Physiology, vol. 5 APR, http://dx.doi.org/10.3389/fphys.2014.00145
Morrison NA; Stephens AS; Osato M; Pasco JA; Fozzard N; Stein GS; Polly P; Griffiths LR; Nicholson GC, 2013, 'Polyalanine Repeat Polymorphism in RUNX2 Is Associated with Site-Specific Fracture in Post-Menopausal Females', PLoS One, vol. 8, no. 9, http://dx.doi.org/10.1371/journal.pone.0072740
Dobson-Stone C; Polly P; Korgaonkar MS; Williams LM; Gordon E; Schofield PR; Mather K; Armstrong NJ; Wen W; Sachdev PS; Kwok JBJ, 2013, 'GSK3B and MAPT Polymorphisms Are Associated with Grey Matter and Intracranial Volume in Healthy Individuals', PLoS One, vol. 8, no. 8, http://dx.doi.org/10.1371/journal.pone.0071750
Shum AMY; Polly P, 2012, 'Cancer Cachexia: Molecular targets and pathways for diagnosis and drug intervention', Endocrine, Metabolic and Immune Disorders - Drug Targets, vol. 12, no. 3, pp. 247 - 259, http://dx.doi.org/10.2174/187153012802002910
Morrison NA; Stephens AA; Osato M; Polly P; Tan TC; Yamashita N; Doecke JD; Pasco J; Fozzard N; Jones G; Ralston SH; Sambrook PN; Prince RL; Nicholson GC, 2012, 'Glutamine repeat variants in human RUNX2 associated with decreased femoral neck BMD, broadband ultrasound attenuation and target gene transactivation', PLoS One, vol. 7, no. 8, http://dx.doi.org/10.1371/journal.pone.0042617
Shum AMY; Mahendradatta T; Taylor RJ; Painter AB; Moore MM; Tsoli M; Tan TC; Clarke SJ; Robertson GR; Polly P, 2012, 'Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting', Aging, vol. 4, no. 2, pp. 133 - 143
Tan T; Shum A; Mahendradatta T; Sarris M; Clarke S; Polly P, 2011, 'Cancer induced cardiomyopathy: maladaptive responses to inflammation', European Heart Journal, vol. 32, pp. 357 - 357, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208702703162&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Hitchins MP; Rapkins RW; Kwok CT; Srivastava S; Wong JJL; Khachigian LM; Polly P; Goldblatt J; Ward RL, 2011, 'Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5'UTR', Cancer Cell, vol. 20, no. 2, pp. 200 - 213, http://dx.doi.org/10.1016/j.ccr.2011.07.003
Brewer MH; Chaudhry R; McDowall K; Chu S; Kowalski B; Polly P; Nicholson G; Kennerson M, 2010, 'X-linked CMT: Genes and gene loci in an Australian cohort', Neurogenetics, vol. 11, no. 2, pp. 267 - 269, http://dx.doi.org/10.1007/s10048-010-0238-5
Matic M; Corradin AP; Tsoli M; Clarke SJ; Polly P; Robertson GR, 2010, 'The alternatively spliced murine pregnane X receptor isoform, mPXRΔ171-211 exhibits a repressive action', The International Journal of Biochemistry and Cell Biology, vol. 42, no. 5, pp. 672 - 682, http://dx.doi.org/10.1016/j.biocel.2010.01.001
Matic M; Nakhel; Lehnert A; Polly P; Clarke SJ; Robertson GR, 2009, 'A novel approach to investigate the subcellular distribution of nuclear receptors in vivo', Nuclear Receptor Signaling, vol. 7, pp. 1 - 7
Brewer M; Changi F; Antonellis A; Fischbeck K; Polly P; Nicholson G; Kennerson M, 2008, 'Evidence of a founder haplotype refines the X-linked Charcot-Marie-Tooth (CMTX3) locus to a 2.5 Mb region', Neurogenetics, vol. 9, no. 3, pp. 191 - 195, http://dx.doi.org/10.1007/s10048-008-0126-4
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