Palmer, Stephen - University of New South Wales

个人简介

Dr Stephen Palmer is a Program Director at Novogen Ltd and Conjoint Senior Lecturer at UNSW Australia. He is a former member of the Cellular and Genetic Medicine Unit in the School of Medical Sciences with research interests in understanding the role of the gene GTF2IRD1 in brain development and human behaviour and its contribution towards the characteristic features of Williams-Beuren syndrome. Stephen Palmer completed his PhD at University College London in 1992 and was awarded an MRC Postdoctoral Training Fellowship to work with Alan Ashworth at the Institute of Cancer Research. In 1997, he came to Australia on a Wellcome Trust International Travelling Fellowship, to work with Richard Harvey at the Victor Chang Cardiac Reserach Institute. After a brief spell back in the UK, Stephen returned to Australia in 2002, joining Edna Hardeman at the Children's Medical Research Institute and then on to UNSW Australia in 2009.

研究领域

drug development, cell biology, biochemistry, gene regulation, embryology, genetics and mouse models of disease

近期论文

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Corley SM; Canales CP; Carmona-Mora P; Mendoza-Reinosa V; Beverdam A; Hardeman EC; Wilkins MR; Palmer SJ, 2016, 'RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome', BMC Genomics, vol. 17, no. 1, http://dx.doi.org/10.1186/s12864-016-2801-4 Carmona-Mora P; Widagdo J; Tomasetig F; Canales CP; Cha Y; Lee W; Alshawaf A; Dottori M; Whan RM; Hardeman EC; Palmer SJ, 2015, 'The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation', Human Genetics, http://dx.doi.org/10.1007/s00439-015-1591-0 Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams–Beuren Syndrome', European Journal of Human Genetics, vol. 23, no. 6, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188 Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PRBB; Sequeira VB; Butler TL; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer SJ; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning PW, 2013, 'A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells', Cancer Research, vol. 73, no. 16, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501 Howard ML; Palmer SJ; Taylor KM; Arthurson GJ; Spitzer MW; Du X; Pang TYC; Renoir T; Hardeman EC; Hannan AJ, 2012, 'Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations', Neurobiology of Disease, vol. 45, no. 3, pp. 913 - 922, http://dx.doi.org/10.1016/j.nbd.2011.12.010 Widagdo J; Taylor KM; Gunning PW; Hardeman EC; Palmer SJ, 2012, 'SUMOylation of GTF2IRD1 Regulates Protein Partner Interactions and Ubiquitin-Mediated Degradation', PLoS One, vol. 7, no. 11, http://dx.doi.org/10.1371/journal.pone.0049283 Palmer SJ; Taylor KM; Santucci N; Widagdo J; Chan YKA; Yeo JL; Adams M; Gunning PW; Hardeman EC, 2012, 'GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members', Journal of Cell Science, vol. 125, no. 21, pp. 5040 - 5050, http://dx.doi.org/10.1242/jcs.102798 Palmer SJ; Santucci N; Widagdo J; Bontempo SJ; Taylor KM; Tay ESE; Hook J; Lemckert F; Gunning PW; Hardeman EC, 2010, 'Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism', Journal of Biological Chemistry, vol. 285, no. 7, pp. 4715 - 4724, http://dx.doi.org/10.1074/jbc.M109.086660 Wilhelm D; Palmer S; Koopman P, 2007, 'Sex determination and gonadal development in mammals', Physiological Reviews, vol. 87, no. 1, pp. 1 - 28, http://dx.doi.org/10.1152/physrev.00009.2006 Palmer SJ; Tay ES; Santucci N; Cuc Bach TT; Hook J; Lemckert FA; Jamieson RV; Gunning PW; Hardeman EC, 2007, 'Expression of Gtf2ird1, the Williams syndrome-associated gene during mouse development', Gene Expression Patterns, vol. 7, no. 4, pp. 396 - 404, http://dx.doi.org/10.1016/j.modgep.2006.11.008 Issa LL; Palmer SJ; Guven KL; Santucci N; Hodgson VRM; Popovic K; Joya JE; Hardeman EC, 2006, 'MusTRD can regulate postnatal fiber-specific expression', Developmental Biology, vol. 293, no. 1, pp. 104 - 115, http://dx.doi.org/10.1016/j.ydbio.2006.01.019 Polly P; Haddadi LM; Issa LL; Subramaniam N; Palmer SJ; Tay ESE; Hardeman EC, 2003, 'hMusTRD1α1 represses MEF2 activation of the Troponin I slow enhancer', Journal of Biological Chemistry, vol. 278, no. 38, pp. 36603 - 36610, http://dx.doi.org/10.1074/jbc.M212814200 Perry J; Palmer S; Gabriel A; Ashworth A, 2001, 'A short pseudoautosomal region in laboratory mice', Genome Research, vol. 11, no. 11, pp. 1826 - 1832 Palmer S; Groves N; Schindeler A; Yeoh T; Biben C; Wang CC; Sparrow DB; Barnett L; Jenkins NA; Copeland NG; Koentgen F; Mohun T; Harvey RP, 2001, 'The small muscle-specific protein CSl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner', The Journal of Cell Biology, vol. 153, no. 5, pp. 985 - 997, http://dx.doi.org/10.1083/jcb.153.5.985 Christoffels VM; Habets PEMH; Franco D; Campione M; De Jong F; Lamers WH; Bao ZZ; Palmer S; Biben C; Harvey RP; Moorman AFM, 2000, 'Chamber formation and morphogenesis in the developing mammalian heart', Developmental Biology, vol. 223, no. 2, pp. 266 - 278, http://dx.doi.org/10.1006/dbio.2000.9753 Burgoyne PS; Mahadevaiah SK; Perry J; Palmer SJ; Ashworth A, 1998, 'The Y* rearrangement in mice: New insights into a perplexing PAR', Cytogenetic and Genome Research, vol. 80, no. 1-4, pp. 37 - 40 Perry J; Feather S; Smith A; Palmer S; Ashworth A, 1998, 'The human FXY gene is located within Xp22.3: Implications for evolution of the mammalian X chromosome', Human Molecular Genetics, vol. 7, no. 2, pp. 299 - 305, http://dx.doi.org/10.1093/hmg/7.2.299 Korobova O; Lane PW; Perry J; Palmer S; Ashworth A; Davisson MT; Arnheim N, 1998, 'Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region', Genomics, vol. 54, no. 3, pp. 556 - 559, http://dx.doi.org/10.1006/geno.1998.5528 Palmer S; Perry J; Kipling D; Ashworth A, 1997, 'A gene spans the pseudoautosomal boundary in mice', Proceedings of the National Academy of Sciences of USA, vol. 94, no. 22, pp. 12030 - 12035, http://dx.doi.org/10.1073/pnas.94.22.12030 Kipling D; Wilson HE; Thomson EJ; Lee M; Perry J; Palmer S; Ashworth A; Cooke HJ, 1996, 'Structural variation of the pseudoautosomal region between and within inbred mouse strains', Proceedings of the National Academy of Sciences of USA, vol. 93, no. 1, pp. 171 - 175, http://dx.doi.org/10.1073/pnas.93.1.171