研究领域

Cardiology and Vascular Disease, Pharmacology, Physiology

Autoregulation of blood flow is the ability of tissues to control 'local' blood flow in response to changes in systemic blood pressure and the tissue's metabolic requirements. Our research focusses on the mechanisms of blood flow autoregulation; pressure-induced changes in the diameter of arterioles (myogenic mechanisms) and alteration of arteriolar diameter in response to metabolic products (metabolic mechanisms). We are also interested in the effect of metabolic diseases such as obesity and diabetes on small artery function.

近期论文

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Quek KJ; Boyd R; Ameer OZ; Zangerl B; Butlin M; Murphy TV; Avolio AP; Phillips JK, 2016, 'Progressive vascular remodelling, endothelial dysfunction and stiffness in mesenteric resistance arteries in a rodent model of chronic kidney disease', Vascular Pharmacology, vol. 81, pp. 42 - 52, http://dx.doi.org/10.1016/j.vph.2015.12.004 Murphy TV; Kanagarajah A; Toemoe S; Bertrand PP; Grayson TH; Britton FC; Leader L; Senadheera S; Sandow SL, 2016, 'TRPV3 expression and vasodilator function in isolated uterine radial arteries from non-pregnant and pregnant rats', Vascular Pharmacology, vol. 83, pp. 66 - 77, http://dx.doi.org/10.1016/j.vph.2016.04.004 Kerr PM; Wei R; Tam R; Sandow SL; Murphy TV; Ondrusova K; Lunn SE; Tran CHT; Welsh DG; Plane F, 2015, 'Activation of endothelial IKCa channels underlies NO-dependent myoendothelial feedback', Vascular Pharmacology, http://dx.doi.org/10.1016/j.vph.2015.09.001 Holobotovskyy V; Chong YS; Burchell J; He B; Phillips M; Leader L; Murphy TV; Sandow SL; McKitrick DJ; Charles AK; Tare M; Arnolda LF; Ganss R, 2015, 'Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia', Science Translational Medicine, vol. 7, no. 290, http://dx.doi.org/10.1126/scitranslmed.aaa5038 Ellinsworth DC; Earley S; Murphy TV; Sandow SL, 2014, 'Endothelial control of vasodilation: Integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids', Pfluegers Archiv: European journal of physiology, vol. 466, no. 3, pp. 389 - 405, http://dx.doi.org/10.1007/s00424-013-1303-3 Howitt L; Sandow SL; Murphy TV; Morris MJ, 2014, 'Effect of diet-induced obesity on BK function in contraction and dilation of rat isolated middle cerebral artery', Vascular Pharmacology, http://dx.doi.org/10.1016/j.vph.2014.02.002 Wang K; Bertrand RL; Senadheera S; Polglaze KE; Murphy TV; Sandow SL; Bertrand PP; Liu L; Bornstein JC, 2013, 'Motility changes induced by intraluminal FeSO in guinea pig jejunum', Neurogastroenterology and Motility, http://dx.doi.org/10.1111/nmo.12276 Senadheera S; Bertrand PP; Grayson TH; Leader L; Tare M; Murphy TV; Sandow SL, 2013, 'Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 305, no. 8, http://dx.doi.org/10.1152/ajpregu.00225.2013 Senadheera S; Grayson TH; Murphy TV; Sandow SL; Bertrand PP; Leader L, 2013, 'Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: Transient receptor potential vanilloid type 4 channels, caveola', Journal of Anatomy, http://dx.doi.org/10.1111/joa.12127 Naser M; Januszeski AS; Brown BE; Jenkins AJ; Hill MA; Murphy TV, 2013, 'Advanced glycation end products acutely impair Ca2+ signaling in bovine aortic endothelial cells', Frontiers in Physiology, vol. 4, pp. Article No. 38, http://dx.doi.org/10.3389/fphys.2013.00038 Grayson TH; Chadha PS; Bertrand PP; Chen H; Morris MJ; Senadheera S; Murphy TV; Sandow SL, 2013, 'Increased caveolae density and caveolin-1 expression accompany impaired NO-mediated vasorelaxation in diet-induced obesity', Histochemistry and Cell Biology, vol. 139, no. 2, pp. 309 - 321, http://dx.doi.org/10.1007/s00418-012-1032-2 Sandow SL; Senadheera S; Grayson TH; Welsh DG; Murphy TV, 2012, 'Calcium and endothelium-mediated vasodilator signaling', Advances in Experimental Medicine and Biology, vol. 740, pp. 811 - 831, http://dx.doi.org/10.1007/978-94-007-2888-2_36 Sandow SL; Senadheera S; Bertrand PP; Murphy TV; Tare M, 2012, 'Myoendothelial Contacts, Gap Junctions, and Microdomains: Anatomical Links to Function?', Microcirculation, vol. 19, no. 5, pp. 403 - 415, http://dx.doi.org/10.1111/j.1549-8719.2011.00146.x Howitt L; Hilton Grayson T; Morris MJ; Sandow SL; Murphy TV, 2012, 'Dietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: Association with caveolins and caveolae', American Journal of Physiology: Heart and Circulatory Physiology, vol. 302, no. 12, pp. 2464 - 2476, http://dx.doi.org/10.1152/ajpheart.00965.2011 Senadheera S; Kim Y; Grayson TH; Toemoe S; Kochukov MY; Abramowitz J; Housley GD; Bertrand RL; Chadha PS; Bertrand PP; Murphy TV; Tare M; Birnbaumer L; Marrelli SP; Sandow SL, 2012, 'Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity', Cardiovascular Research, vol. 95, no. 4, pp. 439 - 447, http://dx.doi.org/10.1093/cvr/cvs208 Howitt L; Sandow SL; Grayson TH; Ellis ZE; Morris MJ; Murphy TV, 2011, 'Differential effects of diet-induced obesity on BKca β1-subunit expression and function in rat skeletal muscle arterioles and small cerebral arteries', American Journal of Physiology: Heart and Circulatory Physiology, vol. 301, no. 1, http://dx.doi.org/10.1152/ajpheart.00134.2011 Bertrand RL; Senadheera S; Markus I; Liu L; Howitt L; Chen H; Murphy TV; Sandow SL; Bertrand PP, 2011, 'A western diet increases serotonin availability in rat small intestine', Endocrinology, vol. 152, no. 1, pp. 36 - 47, http://dx.doi.org/10.1210/en.2010-0377 Chadha PS; Liu L; Rikard-Bell M; Senadheera S; Howitt L; Bertrand RL; Grayson TH; Murphy TV; Sandow SL, 2011, 'Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide', Journal of Pharmacology and Experimental Therapeutics, vol. 336, no. 3, pp. 701 - 708, http://dx.doi.org/10.1124/jpet.110.165795 Murphy TV; Jenkins AJ; Hill MA; Naser N, 2010, 'Effect of advanced glycation end products on dilation of rat skeletal muscle arterioles', The FASEB Journal, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675507367&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Sandow SL; Murphy TV, 2010, 'Under pressure - Kv channels and myogenic control of cerebral blood flow', The Journal of Physiology, vol. 588, no. 19, pp. 3635 - 3636, http://dx.doi.org/10.1113/jphysiol.2010.197996