Morris, Margaret - University of New South Wales

个人简介

Professor Margaret Morris is chair and Head of Pharmacology, School of Medical Sciences, University of NSW. She uses neuropharmacological approaches to explore underlying brain mechanisms in epilepsy, obesity, diabetes, and the link between obesity and high blood pressure. She has developed models of voluntary high fat feeding in rat and mice. The impact of parental obesity and early childhood events has been a key focus of research. Her lab has worked extensively on the impact of maternal obesity on offspring metabolic and cardiovascular risk, and is currently exploring options for intervention. Recent work investigating the role of paternal obesity on the health of offspring demonstrated that when rat fathers were fed a high fat diet to induce obesity and glucose intolerance, the resulting female offspring exhibited impaired glucose tolerance and insulin secretion as young adults (Nature, 2010). Other major research questions Professor Morris explores is how does provision of a varied, energy rich diet override the regulatory control mechanisms that should maintain body weight? The Morris lab showed that palatable high fat diet can ameliorate the behavioral effects of early life stress; notably voluntary exercise had similar benefits (Psychoneuroendocrinology 2010).

研究领域

Medical Biochemistry and Metabolomics

近期论文

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Reichelt AC; Morris MJ; Westbrook RF, 2016, 'Daily access to sucrose impairs aspects of spatial memory tasks reliant on pattern separation and neural proliferation in rats', Learning and Memory, vol. 23, no. 7, pp. 386 - 390, http://dx.doi.org/10.1101/lm.042416.116 Beilharz JE; Kaakoush NO; Maniam J; Morris MJ, 2016, 'The effect of short-term exposure to energy-matched diets enriched in fat or sugar on memory, gut microbiota and markers of brain inflammation and plasticity.', Brain, Behavior, and Immunity, http://dx.doi.org/10.1016/j.bbi.2016.07.151 Kaakoush NO; Morris MJ, 2016, 'The oesophageal microbiome: an unexplored link in obesity-associated oesophageal adenocarcinoma.', FEMS Microbiology Ecology, vol. 92, no. 10, http://dx.doi.org/10.1093/femsec/fiw161 Chowdhury MKH; Wu LE; Coleman JLJ; Smith NJ; Morris MJ; Shepherd PR; Smith GC, 2016, 'Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling', Biochemical Journal, vol. 473, no. 9, pp. 1247 - 1255, http://dx.doi.org/10.1042/BCJ20160121 Maniam J; Antoniadis CP; Le V; Morris MJ, 2016, 'A diet high in fat and sugar reverses anxiety-like behaviour induced by limited nesting in male rats: Impacts on hippocampal markers', Psychoneuroendocrinology, vol. 68, pp. 202 - 209, http://dx.doi.org/10.1016/j.psyneuen.2016.03.007 Kaakoush NO; Martire SI; Raipuria M; Mitchell HM; Nielsen S; Westbrook RF; Morris MJ, 2016, 'Alternating or continuous exposure to cafeteria diet leads to similar shifts in gut microbiota compared to chow diet', Molecular Nutrition and Food Research, http://dx.doi.org/10.1002/mnfr.201500815 Morris MJ; Le V; Maniam J, 2016, 'The impact of poor diet and early life stress on memory status', Current Opinion in Behavioral Sciences, vol. 9, pp. 144 - 151, http://dx.doi.org/10.1016/j.cobeha.2016.04.002 Sharpe MJ; Clemens KJ; Morris MJ; Westbrook RF, 2016, 'Daily Exposure to Sucrose Impairs Subsequent Learning About Food Cues: A Role for Alterations in Ghrelin Signaling and Dopamine D2 Receptors', Neuropsychopharmacology, vol. 41, no. 5, pp. 1357 - 1365, http://dx.doi.org/10.1038/npp.2015.287 Beilharz JE; Maniam J; Morris MJ, 2016, 'Short-term exposure to a diet high in fat and sugar, or liquid sugar, selectively impairs hippocampal-dependent memory, with differential impacts on inflammation', Behavioural Brain Research, vol. 306, pp. 1 - 7, http://dx.doi.org/10.1016/j.bbr.2016.03.018 Maniam J; Antoniadis CP; Youngson NA; Sinha JK; Morris MJ, 2016, 'Sugar consumption produces effects similar to early life stress exposure on hippocampal markers of neurogenesis and stress response', Frontiers in Molecular Neuroscience, vol. 8, no. JAN2016, http://dx.doi.org/10.3389/fnmol.2015.00086 Reichelt AC; Abbott KN; Westbrook RF; Morris MJ, 2016, 'Differential motivational profiles following adolescent sucrose access in male and female rats', Physiology and Behavior, vol. 157, pp. 13 - 19, http://dx.doi.org/10.1016/j.physbeh.2016.01.038 Yang M; Ozturk E; Salzberg MR; Rees S; Morris M; O'Brien TJ; Jones NC, 2016, 'Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity', Epilepsia, http://dx.doi.org/10.1111/epi.13299 Abbott KN; Morris MJ; Westbrook RF; Reichelt AC, 2015, 'Sex-specific effects of daily exposure to sucrose on spatial memory performance in male and female rats, and implications for estrous cycle stage', Physiology and Behavior, vol. 162, pp. 52 - 60, http://dx.doi.org/10.1016/j.physbeh.2016.01.036 Reichelt AC; Westbrook RF; Morris MJ, 2015, 'Integration of reward signalling and appetite regulating peptide systems in the control of food-cue responses', British Journal of Pharmacology, http://dx.doi.org/10.1111/bph.13321 Morris MJ; Beilharz JE; Maniam J; Reichelt AC; Westbrook RF, 2015, 'Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition', Neuroscience and Biobehavioral Reviews, vol. 58, pp. 36 - 45, http://dx.doi.org/10.1016/j.neubiorev.2014.12.002 Youngson NA; Lecomte V; Maloney CA; Leung P; Liu J; Hesson LB; Luciani F; Krause L; Morris MJ, 2015, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring.', Asian Journal of Andrology, http://dx.doi.org/10.4103/1008-682X.163190 Maniam J; Antoniadis CP; Wang KW; Morris MJ, 2015, 'Early life stress induced by limited nesting material produces metabolic resilience in response to a high-fat and high-sugar diet in male rats', Frontiers in Endocrinology, vol. 6, no. SEP, http://dx.doi.org/10.3389/fendo.2015.00138 Beilharz JE; Maniam J; Morris MJ, 2015, 'Diet-induced cognitive deficits: The role of fat and sugar, potential mechanisms and nutritional interventions', Nutrients, vol. 7, no. 8, pp. 6719 - 6738, http://dx.doi.org/10.3390/nu7085307 Maniam J; Antoniadis CP; Morris MJ, 2015, 'The effect of early-life stress and chronic high-sucrose diet on metabolic outcomes in female rats', Stress: the International Journal on the Biology of Stress, http://dx.doi.org/10.3109/10253890.2015.1079617 Raipuria M; Hardy GO; Bahari H; Morris MJ, 2015, 'Maternal obesity regulates gene expression in the hearts of offspring', Nutrition Metabolism and Cardiovascular Diseases, http://dx.doi.org/10.1016/j.numecd.2015.05.011