研究领域

Neurosciences

Damage to the nervous system is often associated with chronic neuropathic pain symptoms including spontaneous pain, increased sensitivity to painful stimuli (hyperalgesia), and pain perceived in response to normally non-painful stimuli (allodynia). Such pain is extremely debilitating and difficult to treat. My current research focuses on the mechanisms underlying neuropathic pain, with particular emphasis on how immune cells and inflammatory mediators influence chronic pain following peripheral nerve injury or autoimmune inflammation in the nervous system.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Lees JG; Fivelman B; Duffy SS; Makker PGS; Perera CJ; Moalem-Taylor G, 2015, 'Cytokines in neuropathic pain and associated depression', Modern Trends in Pharmacopsychiatry, vol. 30, pp. 51 - 66, http://dx.doi.org/10.1159/000435932 Perera CJ; Lees JG; Duffy SS; Makker PGS; Fivelman B; Apostolopoulos V; Moalem-Taylor G, 2015, 'Effects of active immunisation with myelin basic protein and myelin-derived altered peptide ligand on pain hypersensitivity and neuroinflammation', Journal of Neuroimmunology, vol. 286, pp. 59 - 70, http://dx.doi.org/10.1016/j.jneuroim.2015.07.004 Perera CJ; Duffy SS; Lees JG; Kim CF; Cameron B; Apostolopoulos V; Moalem-Taylor G, 2015, 'Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury', Journal of Neuroinflammation, vol. 12, no. 1, http://dx.doi.org/10.1186/s12974-015-0253-4 Tonkin RS; Mao Y; O'carroll SJ; Nicholson LFB; Green CR; Gorrie CA; Moalem-Taylor G, 2015, 'Gap junction proteins and their role in spinal cord injury', Frontiers in Molecular Neuroscience, vol. 7, no. JAN, http://dx.doi.org/10.3389/fnmol.2014.00102 Lees JG; Duffy SS; Perera CJ; Moalem-Taylor G, 2015, 'Depletion of Foxp3+ regulatory T cells increases severity of mechanical allodynia and significantly alters systemic cytokine levels following peripheral nerve injury', Cytokine, vol. 71, no. 2, pp. 207 - 214, http://dx.doi.org/10.1016/j.cyto.2014.10.028 Duffy SS; Lees JG; Moalem-Taylor G, 2014, 'The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis.', Multiple Sclerosis International, vol. 2014, pp. 285245, http://dx.doi.org/10.1155/2014/285245 Tian DH; Perera CJ; Apostolopoulos V; Moalem-Taylor G, 2013, 'Effects of vaccination with altered peptide ligand on chronic pain in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis', Frontiers in Neurology, http://dx.doi.org/10.3389/fneur.2013.00168 Lees JG; Duffy SS; Moalem-Taylor G, 2013, 'Immunotherapy targeting cytokines in neuropathic pain', Frontiers in Pharmacology, vol. 4 NOV, http://dx.doi.org/10.3389/fphar.2013.00142 Tian DH; Perera CJ; Moalem-Taylor G, 2013, 'Neuropathic pain in animal models of nervous system autoimmune diseases', Mediators of Inflammation, vol. 2013, http://dx.doi.org/10.1155/2013/298326 Wu A; Green CR; Rupenthal ID; Moalem-Taylor G, 2012, 'Role of gap junctions in chronic pain', Journal of Neuroscience Research, vol. 90, no. 2, pp. 337 - 345, http://dx.doi.org/10.1002/jnr.22764 Austin PJ; Wu A; Moalem-Taylor G, 2012, 'Chronic constriction of the sciatic nerve and pain hypersensitivity testing in rats.', Journal of Visualized Experiments, no. 61 Austin PJ; Kim CF; Perera CJ; Moalem-Taylor G, 2012, 'Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis', Pain, vol. 153, no. 9, pp. 1916 - 1931, http://dx.doi.org/10.1016/j.pain.2012.06.005 Moalem-Taylor G; Li M; Allbutt HN; Wu A; Tracey DJ, 2011, 'A preconditioning nerve lesion inhibits mechanical pain hypersensitivity following subsequent neuropathic injury', Molecular Pain, vol. 7, no. 1, pp. 1 - 1, http://dx.doi.org/10.1186/1744-8069-7-1 Hill F; Kim CF; Gorrie CA; Moalem-Taylor G, 2011, 'Interleukin-17 deficiency improves locomotor recovery and tissue sparing after spinal cord contusion injury in mice', Neuroscience Letters, vol. 487, no. 3, pp. 363 - 367, http://dx.doi.org/10.1016/j.neulet.2010.10.057 Kim CF; Moalem-Taylor G, 2011, 'Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice', Journal of Pain, vol. 12, no. 3, pp. 370 - 383, http://dx.doi.org/10.1016/j.jpain.2010.08.003 Kim CF; Moalem-Taylor G, 2011, 'Detailed characterization of neuro-immune responses following neuropathic injury in mice', Brain Research, vol. 1405, pp. 95 - 108, http://dx.doi.org/10.1016/j.brainres.2011.06.022 Austin PJ; Moalem-Taylor G, 2010, 'The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines', Journal of Neuroimmunology, vol. 229, no. 1-2, pp. 26 - 50, http://dx.doi.org/10.1016/j.jneuroim.2010.08.013 Moalem-Taylor G; Allbutt HN; Iordanova MD; Tracey DJ, 2007, 'Pain hypersensitivity in rats with experimental autoimmune neuritis, an animal model of human inflammatory demyelinating neuropathy', Brain, Behavior, and Immunity, vol. 21, no. 5, pp. 699 - 710, http://dx.doi.org/10.1016/j.bbi.2006.07.007