研究领域

Regenerative Medicine (incl. Stem Cells and Tissue Engineering)

Dr Helder Marçal has years of recognised research experience in tissue engineering technologies and stem cell regenerative medicine therapeutics. His research spans multidisciplinary fields of biomedical engineering, stem-cell therapeutics, expression proteomics, biomaterials and nerve regeneration. His expertise utilises the salamander as a model with a focus on nerve tissue repair and regeneration. In addition, he has identified a molecular mimicry mechanism involved in the immune-pathogenesis of reactive arthritis, psoriatic arthritis, uveitis and ankylosing spondylitis. These are associated with individuals that are HLA-B27 positive and autoimmunity. This technology opens the way for the development of the first peptide vaccine to inhibit the immunopathogenesis of these diseases. Dr Marçal was a finalist for UNSWs inventor of the year. His research has been highlighted in the Sydney Morning Herald, Discovery Channel, ABC Catalyst show, The Sunday Telegraph, NASA News and New York Times. He has established international collaborations involving these technologies in the field of regenerative and translational medicine and presented at numerous international conferences. Dr Marçal’s knowledge and skills also span across innovative research areas that include tissue regeneration in space. This is a project that is investigating the impact of space travel especially, microgravity and its effect on human stem cells and tissue regeneration. This is a new area of research called Bioastronautics. He has been a visiting scientist at the Penguin Automated Research Centre (Canada), McGowan Institute for Regenerative Medicine (Pittsburgh), European Stem Cell Centre of Excellence (Portugal), and the Californian Institute for Regenerative Medicine (USA).

近期论文

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Castellano-González G; Pichaud N; Ballard JWO; Bessede A; Marcal H; Guillemin GJ, 2016, 'Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes', Oncotarget, vol. 7, no. 7, pp. 7426 - 7440, http://dx.doi.org/10.18632/oncotarget.6863 Hassarati RT; Marcal H; John L; Foster R; Green RA, 2016, 'Biofunctionalization of conductive hydrogel coatings to support olfactory ensheathing cells at implantable electrode interfaces', Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 104, no. 4, pp. 712 - 722, http://dx.doi.org/10.1002/jbm.b.33497 Foster LJR; Ho S; Hook J; Basuki M; Marçal H, 2015, 'Chitosan as a biomaterial: Influence of degree of deacetylation on its physiochemical, material and biological properties', PLoS One, vol. 10, no. 8, http://dx.doi.org/10.1371/journal.pone.0135153 Hasse B; Tarr PE; Marques-Vidal P; Waeber G; Preisig M; Mooser V; Valeri F; Djalali S; Andri R; Bernasconi E; Calmy A; Cavassini M; Vernazza P; Battegay M; Weber R; Senn O; Vollenweider P; Ledergerber B; CoLaus Cohort, FIRE and the Swiss HIV Cohort Study; Aubert V; Barth J; Battegay M; Bernasconi E; Böni J; Bucher HC; Burton-Jeangros C; Calmy A; Cavassini M; Egger M; Elzi L; Fehr J; Fellay J; Furrer H; Fux CA; Gorgievski M; Günthard H; Haerry D; Hasse B; Hirsch HH; Hösli I; Kahlert C; Kaiser L; Keiser O; Klimkait T; Kouyos R; Kovari H; Ledergerber B; Martinetti G; Martinez de Tejada B; Metzner K; Müller N; Nadal D; Pantaleo G; Rauch A; Regenass S; Rickenbach M; Rudin C; Schöni-Affolter F; Schmid P; Schultze D; Schüpbach J; Speck R; Staehelin C; Tarr P; Telenti A; Trkola A; Vernazza P; Weber R; Yerly S; Jean-Michel A; Murielle B; Jean Michel G; Christoph H; Thomas L; Pedro MV; Vincent M; Fred P; Martin P; Peter V; Roland VK; Aidacic V; Gerard W; Jürg B; Markus B; Heinz B; Martin B; Hans-Ulrich B; Ivo B; Reto C; Isabelle C; Corinne C; Sima D; Peter D; Simone E; Andrea F; Markus F; Claudius F; Jakob F; Ali GM; Matthias G; Denis H; Marcel H; Walter H; Simon H; Felix H; Paul H; Eva K; Vladimir K; Daniel K; Stephan K; Beat K; Benedict K; Heidi K; Vesna L; Giovanni L; Werner LH; Phillippe L; Severin L; Christoph M; Jürgen M; Damian M; Werner M; Titus M; Valentina N; Jakob R; Thomas R; Hana S; Frank S; Georg S; Oliver S; Pietro S; Jacques S; Alfred S; Alois S; Claudia S; Othm, 2015, 'Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population.', Open Forum Infectious Diseases, vol. 2, no. 3, pp. ofv108, http://dx.doi.org/10.1093/ofid/ofv108 Chiu AS; Braidy N; Marçal H; Welch JH; Gehringer MM; Guillemin GJ; Neilan BA, 2015, 'Global cellular responses to β-methyl-amino-l-alanine (BMAA) by olfactory ensheathing glial cells (OEC)', Toxicon, vol. 99, pp. 136 - 145, http://dx.doi.org/10.1016/j.toxicon.2015.03.009 Ho S; Marçal H; Foster LJR, 2014, 'Towards scarless wound healing: A comparison of protein expression between human, adult and foetal fibroblasts', BioMed Research International, vol. 2014, http://dx.doi.org/10.1155/2014/676493 Chan RTH; Russell RA; Marçal H; Lee TH; Holden PJ; Foster LJR, 2014, 'BioPEGylation of polyhydroxybutyrate promotes nerve cell health and migration', Biomacromolecules, vol. 15, no. 1, pp. 339 - 349, http://dx.doi.org/10.1021/bm401572a Ralf K; Mathias E; Marcel H; Friedrich C; Jörg B, 2013, 'The relationship of is and law - the perspective of and implications for is research', ECIS 2013 - Proceedings of the 21st European Conference on Information Systems Chan RT; Marçal H; Ahmed T; Russell RA; Holden PJ; Foster LJR, 2013, 'Poly(ethylene glycol)-modulated cellular biocompatibility of polyhydroxyalkanoate films', Polymer International, vol. 62, no. 6, pp. 884 - 892, http://dx.doi.org/10.1002/pi.4451 Chan TH; Marcal H; Russell RA; Holden PJ; Foster LJR, 2012, 'Polyhydroxybutyrate and polyethylene glycol composites as biomaterials for biomedical applications', Journal of Tissue Engineering and Regenerative Medicine, vol. 6, pp. 208 - 208, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308313001372&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Maral H; Ahmed T; Badylak SF; Tottey S; Foster LJR, 2012, 'A comprehensive protein expression profile of extracellular matrix biomaterial derived from porcine urinary bladder', Regenerative Medicine, vol. 7, no. 2, pp. 159 - 166, http://dx.doi.org/10.2217/rme.12.6 Marcal H; Ahmed T; Wanandy N; Foster J, 2012, 'Spinal cord repair and regeneration: The application of bioadhesives and extracellular matrix bioscaffolds', Advanced Materials Research, vol. 506, pp. 19 - 22, http://dx.doi.org/10.4028/www.scientific.net/AMR.506.19 Thomson K; Marçal H; Shabazi J; Watson S; Wakefield D; Foster LJR, 2012, 'SurgiLux: A novel thin film, laser-activated bioadhesive for corneal repair', Advanced Materials Research, vol. 506, pp. 7 - 10, http://dx.doi.org/10.4028/www.scientific.net/AMR.506.7 Chan RTH; Marçal H; Russell RA; Holden PJ; Foster LJR, 2011, 'Application of polyethylene glycol to promote cellular biocompatibility of polyhydroxybutyrate films', International Journal of Polymer Science, vol. 2011, http://dx.doi.org/10.1155/2011/473045 Chan RTH; Garvey CJ; Marçal H; Russell RA; Holden PJ; Foster LJR, 2011, 'Manipulation of polyhydroxybutyrate properties through blending with ethyl-cellulose for a composite biomaterial', International Journal of Polymer Science, vol. 2011, http://dx.doi.org/10.1155/2011/651549 Shahbazi J; Marçal H; Watson S; Wakefield D; Sarris M; Foster LJR, 2011, 'Sutureless sealing of penetrating corneal wounds using a laser-activated thin film adhesive', Lasers in Surgery and Medicine, vol. 43, no. 6, pp. 490 - 498, http://dx.doi.org/10.1002/lsm.21076 Foster LJR; Thomson K; Marçal H; Butt J; Watson SL; Wakefield D, 2010, 'Chitosan-vancomysin composite biomaterial as a laser activated surgical adhesive with regional antimicrobial activity', Biomacromolecules, vol. 11, no. 12, pp. 3563 - 3570, http://dx.doi.org/10.1021/bm101028g Marçal H; Wanandy NS; Sanguanchaipaiwong V; Woolnough CE; Lauto A; Mahler SM; Foster LJR, 2008, 'BioPEGylation of polyhydroxyalkanoates: Influence on properties and satellite-stem cell cycle', Biomacromolecules, vol. 9, no. 10, pp. 2719 - 2726, http://dx.doi.org/10.1021/bm800418e Dinnes DLM; Marçal H; Raftery MJ; Labow RS; Mahler SM, 2008, 'The macrophage-biomaterial interface: A proteomic analysis of the conditioned medium environment', Journal of Chemical Technology and Biotechnology, vol. 83, no. 4, pp. 482 - 495, http://dx.doi.org/10.1002/jctb.1854 Marçal H; Sarris M; Raftery MJ; Bhasin V; McFarland C; Mahler SM, 2008, 'Expression proteomics of olfactory ensheathing cells', Journal of Chemical Technology and Biotechnology, vol. 83, no. 4, pp. 473 - 481, http://dx.doi.org/10.1002/jctb.1900