研究领域

Biochemistry and Cell Biology not elsewhere classified

My research interests are centred on the ‘fetal programming of adult disease’. The question I am seeking to answer is “How is it that poor maternal nutrition during gestation can permanently alter the developing offspring so that it is predisposed to develop diabetes, obesity and other components of the metabolic syndrome”. This has lead me to investigate both, what is it in the diet that can programme and to study epigenetics, in particular DNA methylation as a means of permanently altering gene expression and hence metabolism. More recently I have focused my research on the newly discovered small non-coding RNA as molecules of both fetal programming and transgenerational inheritance.

近期论文

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Youngson NA; Lecomte V; Maloney CA; Leung P; Liu J; Hesson LB; Luciani F; Krause L; Morris MJ, 2015, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring.', Asian Journal of Andrology, http://dx.doi.org/10.4103/1008-682X.163190 Lecomte V; Kaakoush NO; Maloney CA; Raipuria M; Huinao KD; Mitchell HM; Morris MJ, 2015, 'Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters', PLoS One, vol. 10, no. 5, http://dx.doi.org/10.1371/journal.pone.0126931 Ng SF; Lin RCY; Maloney CA; Youngson NA; Owens JA; Morris MJ, 2014, 'Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring', The FASEB Journal, vol. 28, no. 4, pp. 1830 - 1841, http://dx.doi.org/10.1096/fj.13-244046 Lecomte V; Youngson NA; Maloney CA; Morris MJ, 2013, 'Parental programming: How can we improve study design to discern the molecular mechanisms?', BioEssays, vol. 35, no. 9, pp. 787 - 793, http://dx.doi.org/10.1002/bies.201300051 Maloney CA; Hay SM; Reid MD; Duncan G; Nicol F; Sinclair KD; Rees WD, 2013, 'A methyl-deficient diet fed to rats during the pre- and peri-conception periods of development modifies the hepatic proteome in the adult offspring', Genes and Nutrition, vol. 8, no. 2, pp. 181 - 190, http://dx.doi.org/10.1007/s12263-012-0314-6 Li CCY; Young PE; Maloney CA; Eaton SA; Cowley MJ; Buckland ME; Preiss T; Henstridge DC; Cooney GJ; Febbraio MA; Martin DIK; Cropley JE; Suter CM, 2013, 'Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice', Epigenetics, vol. 8, no. 6, http://dx.doi.org/10.4161/epi.24656 Maloney CA; Hay SM; Young LE; Sinclair KD; Rees WD, 2011, 'A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring 1-3', The Journal of Nutrition, vol. 141, no. 1, pp. 95 - 100, http://dx.doi.org/10.3945/jn.109.119453 Lawlor KT; O'Keefe LV; Samaraweera SE; van Eyk CL; McLeod CJ; Maloney CA; Dang THY; Suter CM; Richards RI, 2011, 'Double-stranded RNA is pathogenic in Drosophila models of expanded repeat neurodegenerative diseases', Human Molecular Genetics, vol. 20, no. 19, pp. 3757 - 3768, http://dx.doi.org/10.1093/hmg/ddr292 Gosby AK; Maloney CA; Caterson ID, 2010, 'Elevated insulin sensitivity in low-protein offspring rats is prevented by a high-fat diet and is associated with visceral fat', Obesity, vol. 18, no. 8, pp. 1593 - 1600, http://dx.doi.org/10.1038/oby.2009.449 Li CCY; Maloney CA; Cropley JE; Suter CM, 2010, 'Epigenetic programming by maternal nutrition: Shaping future generations', Epigenomics, vol. 2, no. 4, pp. 539 - 549, http://dx.doi.org/10.2217/epi.10.33 Gosby AK; Stanton LML; Maloney CA; Thompson M; Briody J; Baxter RC; Bryson JM; Denyer GS; Caterson ID, 2009, 'Postnatal nutrition alters body composition in adult offspring exposed to maternal protein restriction', The British Journal of Nutrition: an international journal of nutritional science, vol. 101, no. 12, pp. 1878 - 1884, http://dx.doi.org/10.1017/S0007114508135851 Maloney CA; Hay SM; Rees WD, 2009, 'The effects of feeding rats diets deficient in folic acid and related methyl donors on the blood pressure and glucose tolerance of the offspring', The British Journal of Nutrition: an international journal of nutritional science, vol. 101, no. 9, pp. 1333 - 1340, http://dx.doi.org/10.1017/S0007114508066798 Rees WD; McNeil CJ; Maloney CA, 2008, 'The roles of PPARs in the fetal origins of metabolic health and disease', PPAR Research, http://dx.doi.org/10.1155/2008/459030 Mcneil CJ; Hay SM; Rucklidge GJ; Reid M; Duncan G; Maloney CA; Rees WD, 2008, 'Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets', The British Journal of Nutrition: an international journal of nutritional science, vol. 99, no. 2, pp. 262 - 271, http://dx.doi.org/10.1017/S0007114507798999 Maloney CA; Lilley C; Czopek A; Hay SM; Rees WD, 2007, 'Interactions between protein and vegetable oils in the maternal diet determine the programming of the insulin axis in the rat', The British Journal of Nutrition: an international journal of nutritional science, vol. 97, no. 5, pp. 912 - 920, http://dx.doi.org/10.1017/S0007114507659042 Sinclair KD; Allegrucci C; Singh R; Gardner DS; Sebastian S; Bispham J; Thurston A; Huntley JF; Rees WD; Maloney CA; Lea RG; Craigon J; McEvoy TG; Young LE, 2007, 'DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status', Proceedings of the National Academy of Sciences of USA, vol. 104, no. 49, pp. 19351 - 19356, http://dx.doi.org/10.1073/pnas.0707258104 Lobley GE; Bremner DM; Holtrop G; Johnstone AM; Maloney C, 2007, 'Impact of high-protein diets with either moderate or low carbohydrate on weight loss, body composition, blood pressure and glucose tolerance in rats', The British Journal of Nutrition: an international journal of nutritional science, vol. 97, no. 6, pp. 1099 - 1108, http://dx.doi.org/10.1017/S0007114507691934 Maloney CA; Hay SM; Rees WD, 2007, 'Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus', The British Journal of Nutrition: an international journal of nutritional science, vol. 97, no. 6, pp. 1090 - 1098, http://dx.doi.org/10.1017/S0007114507670834 Funnell APW; Maloney CA; Thompson LJ; Keys J; Tallack M; Perkins AC; Crossley M, 2007, 'Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells', Molecular and Cellular Biology, vol. 27, no. 7, pp. 2777 - 2790, http://dx.doi.org/10.1128/MCB.01658-06 Rees WD; Wilson FA; Maloney CA, 2006, 'Sulfur amino acid metabolism in pregnancy: The impact of methionine in the maternal diet', The Journal of Nutrition, vol. 136, no. 6